Article Id: DR-750 | Page : 251-256
Citation :- FOOD ALLERGY: ITS CONTROL BY PROBIOTIC- A Review.Asian Journal of Dairy and Food Research.2013.(32):251-256
Shovna, Suja Senan and J.B. Prajapati
Address : Department of Dairy Microbiology, S. M. C. College of Dairy Science, Anand Agricultural University, Anand- 388 110, India


The cultural diversity of the globe is reflected in the multitude of dietary habits and culinary choices among the people. In this diversity there exists a group of people who have developed an allergic reaction towards some foods. Food allergy is now recognized as a worldwide problem and appears to be on increase because of lifestyle changes in modern times such as changes in the alimentary habits, living conditions, excessive use of antibiotics contributing to immune-deviation. Pharmaceutical medicine has been unable to stop the increasing global morbidity and mortality both in acute and chronic allergic diseases. In view of this, there is a growing awareness of the preventative and therapeutic potential of alternative agents in the medical field. Probiotics, amongst other agents fall into this category and can have direct and positive effect on the prevention of allergic disorder. Many studies have been performed which indicate that probiotics can temporarily modify the composition of gut microbiota, and potentially these can reduce susceptibility to allergy, leading to health benefits for the host.


Allergy Hypersensitivity Immunoglobulins Mechanism Probiotics.


  1. Akagawa M, Handoyo T, Ishii T, Kumazawa S, Morita N, Suyama K (2007). Proteomic analysis of wheat flour allergens. J. Agric. Food Chem. 55 (17): 6863–70.
  2. Albert Helen (2012) .Probiotic Lactobacillus rhamnosus HN001 has protective effect against rhinoconjunctivitis in early childhood, Clin Exp Allergy 15 (4): 12-15.
  3. Andrews R.H.S., Devadatta, Fox W, Radhakrishna S, Ramakrishna CV and Velu S (2011). Indian Journal of Medical Research 23 ;( 12):463-510.
  4. Angelis Maria De (2006) .VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue. European Journal of Clinical Nutrition 176 (2):80 – 93.
  5. Anonymous (2005) National Institutes of Health, NIAID Allergy Statistics, Bethesda, U.K.
  6. Anon (2009) Assessment of current scenario of food labeling in India, National Institute of Nutrition, Hyderabad.
  7. Anon (2010) National Institute of Allergy and Infectious Diseases, Bethesda, U.K.
  8. Babu, P.R, Schmied J, Wilkie B (2009) Prophylaxis of experimental food allergy with probiotic Lactococcus lactis. British Journal of Nutrition 88 (20):112-119.
  9. Barnett, D. Howden ME (1987). Lectins and the radioallergosorbent test. J.Allergy Clin Immunol 80 (4): 558-561.
  10. Breitenbach, AM, Lukacs, SL (2002). Three-year follow-up study of allergy in workers in a mushroom factory
  11. Ciprandi, Pierre, Dominik Grathwal, Jean Marc Labune, Jean Michael Hasoet and Michael Liclere (1986). Assessment of the safety,tolerance, and protective effect against angioedema containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial .Am J Clin Nutr 39 (87):365–731.
  12. Daniel, Huang, Naveena Shanmugam, Jacob, Grotton, and Jeeva, Jacob (2011). Irritable bowel syndrome: epidemiology, natural history, health care seeking and emerging risk factors. Gastroenterol Clin North Am 34 (2): 189-204.
  13. Fiocchi, A, Brozeck, J, Schiinemann H, Bahna S, Von Berg A et al (2010). World Allergy Organization (WAO) Diagnosis and rationale for diagnosis against cow milk allergy (DRACMA) Guidelines.World Allergy Organization Journal 3(4):57-161.
  14. Groce H, Rutherfurd KJ, Cross ML, Gopal PK. (2008). Probiotics in aquaculture: Challenges and outlook. Am J Clin Nutr 89(74):833–900.
  15. Gruber C, Thomas Keil, Michael Kulig, Stephen Roll, Ulrich Wahn.(2008). Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy. J Pediatric Allergy and Immunology. 19 (6):505-512.
  16. Jones, Mitchell L., Christopher J. Martoni , Mathieu Parent and Satya Prakash (2011) . Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. British Journal of Nutrition 12 (8):12-15.
  17. Kalliomaki, M, Salminen, S, Poussa, T (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. J Allergy Clin Immunol 71 (6):361-1869.
  18. Karimi, Khalil, Inman, Mark D, Bienestock, John and Forsythe Paul (2009). Lactobacillus reuteri- Induced regulatory T cells protect against an Allergic Airways Response in mice Am J Respir Crit Med 179 (8):186-193.
  19. Keiko, A., Junyi, S., and Tatsuyoshi, S. (2010). Consumer reaction to information on food additives: Evidence from an eating experiment and a field survey [electronic version]. Journal of Economic Behavior & Organization, 73 (3):433-438.
  20. Konieczna, Patrycja, David, Greogor, Mario Ziegler, Remo Frei, Ruth Frestl, Fergus Shanahan (2011) Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells. An International Journal of Gasteroenterology and Hepatology 61(4):354-366.
  21. Lalles, JP, Peltre, G (1996). Biochemical features of grain legume allergies in humans and animals. Nut Rev 54 (6):101-107.
  22. Lindfors, K, Blomqvist, T, Juuti-Uusitalo K, Stenman S, Venäläinen J, Mäki M, Kaukinen K (2008).Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clinical and Experimental immunology. 145 (12):112-128.
  23. Marschan E, Kuitunen M, Kukkunen K, Poussa T, Varrala O (2008) . Probiotics in infancy induces protective immune profiles that are characteristic for chronic low grade inflammation. J Clinical and Experimental Allergy 38 (4):611-618.
  24. Moneret Vautrin D.A., Morisset M, Flabbee J, Beaudouin E, Kanny G (2005). Epidemiology of life-threatening and lethal anaphylaxis: a review on allergy 60(2): 443–451.
  25. Morisset M, Jacquine Aubert C, Soulaines P and Duopont C (2008). A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy.European Journal of Clinical Nutrition 65 (12):175-183.
  26. Oggioni M, Hansen TK, Mortz C.G, Host A and Jensen Bindslev C (1998). The prevalence of food hypersensitivity in an unselected population of children and adults, Pediatr Allergy Immunol.16 (8):567-573.
  27. Passeron T, Lacour JP, Fontas E, Ortonne JP (2006). Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. J Pediatrics Allergy 61 (88):431–437.
  28. Rosenfeldt V et al (2003).Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 11 (1):389–395.
  29. Sampson HA, McCaskill CC (1985) Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. J Pediatr.107 (34):669–675.
  30. Siecherer Scott (2006) . Food Allergy. J Allergy Clin Immunol 117 (2), 470-475.
  31. Song Y S, Frias J, Martinez C, Vidal C, Gonzalez E (2007). Journal of Food Chemistry 88 (12):123-189.
  32. Sotkovsky P, Sklenar J, Halada P, Cinova J, Setinova I, Kainarova A, Golias J, Pavlaskova K, Honzová S, Tuèkova L (2011). A new approach to the isolation and characterization of wheat flour allergens. Clin Exp Allergy 41(7):1031-1043.
  33. Swert LF (1999). Risk factors for allergy. Eur. J. Pediatr 158 (2): 89–94.
  34. Walfson David ND, Olmstead Stephen MD, Meiss Dennis, Ralston Janet BS, Klaire Labs (2008). PANDAS, Autism Spectrum Disorders and Involvement of Streptococcus Organisms. A division of Prothera.
  35. Wood, R.A. (2003). The natural history of food allergy. J Pediatrics 111 (81):1631-1711.
  36. Wuthrich Adrian , Rodolphe Fritsche, Blaise Cortsey, Annick Merceiner.(2005). Food products and allergy development, prevention and treatment. Curr Opinion Biotechnol. 17 (2):198-203.

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