Asian Journal of Dairy and Food Research, volume 34 issue 4 (december 2015) : 253-258

Biofunctional properties of milk protein derived bioactive peptides - A review

Prasad Patil*, Akanksha Wadehra1, Varsha Garg, Kanchan Munjal, Sudhir Kumar Tomar, Surajit Mandal
1<p>Dairy Microbiology Division,&nbsp;ICAR-National Dairy Research Institute, Karnal-132 001, India.</p>
Cite article:- Patil* Prasad, Wadehra1 Akanksha, Garg Varsha, Munjal Kanchan, Tomar Kumar Sudhir, Mandal Surajit (2015). Biofunctional properties of milk protein derived bioactive peptides - A review . Asian Journal of Dairy and Food Research. 34(4): 253-258. doi: 10.18805/ajdfr.v34i4.6873.

Milk has long been acknowledged as a source of macro- and micro nutrients. Presently, several identified biologically active substances from milk and their derivatives has attracted much attention from the scientific community. These bioactive compounds confer many health benefits that might support disease prevention. Worldwide, there is an increasing interest in the therapeutic potential of bioactive peptides which collectively present a cornucopia of bioactivities for utilization in humans. Bioactive peptides are hydrolysates with specific amino acid sequences that exert a positive physiological effect on the body. Most of the biological activities are encrypted within the primary sequence of the native protein and can be released during digestion by proteolytic enzymes in the gastrointestinal tract or during fermentation and food processing. Milk protein is an important source of bioactive peptides which may contribute to regulate the nervous, gastrointestinal, and cardiovascular systems as well as the immune system. Milk protein derived bioactive peptides are shown to have antihypertensive, antimicrobial, immunomodulatory, antioxidative and mineral-binding properties. Bioactive peptides derived from milk proteins are of particular interest to the food industry due to the potential functional and physiological roles that they exhibit.

  1. Ballard, K. D., Bruno, R. S., Seip, R. L., Quann, E. E., Volk, B. M., Freidenreich, D. J., Kawiecki, D. M., Kupchak, B. R., Chung, M., Kraemer, W. J., Volek, J. S. (2009) Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial. Nutrition Journal, 8: 10-1186

  2. Chabance, B., Jolles, P., Izquierdo, C., Mazoyer, E., Francoual, C., Drouet, L., Fiat A. M. (1995) Characterization of an antithrombotic peptide from kappa-casein in newborn plasma after milk ingestion. Br J Nutr., 73: 583-590

  3. Clare, D. A., Swaisgood, H. E. (2000) Bioactive milk peptides: a prospectus. J. Dairy Sci., 83: 1187-1195

  4. Contreras, M. M., Carrón, R., Montero, M. J., Ramos, M., Recio, I. (2009) Novel casein-derived peptides with antihypertensive activity. International Dairy Journal, 19: 566-573

  5. Contreras, M. M., Sancho, M. A., Recio, I., Mills, C. (2012) Absorption of casein antihypertensive peptides through an in vitro model of intestinal epithelium. Food Digestion, 3: 16-24

  6. Dionysius, D. A., Marschke, R. J., Wood, A. J., Milne, J., Beattie, T. R., Jiang, H., Treloar, T., Alewood, P. F., Grieve, P. A. (2000) Identification of physiologically functional peptides in dairy products. Australian Journal of Dairy Technology, 55: 103

  7. Drucker, D.J., Nauck, M.A. (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-    IV inhibitors in T2D. The Lancet, 368:1696-1705

  8. Everitt, A. V., Hilmer, S. N., Brand-Miller, J. C., Jamieson, H. A., Truswell, A. S., Sharma, A. P., Mason, R. S., Morris, B. J., Le-Couteur, D. G. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1: 11-31

  9. Fitzgerald, G. F., Murray, B. A. (2006) Bioactive peptides and lactic fermentations. Int J Dairy Technol., 59:118-125

  10. Gobbetti, M., Minervini, F., Rizzello, C. G. (2004) Angiotensin I-converting enzyme-inhibitory and antimicrobial bioactive peptides. International Journal of Dairy Technology, 57:173-188

  11. Hayes, M., Ross, R. P., Fitzgerald, G. F., Stanton, C., Hill, C. (2006) Casein-derived antimicrobial peptides generated by Lactobacillus acidophilus DPC6026. Appl. Environ. Microbiol., 72: 2260-2264

  12. Hernandez-Ledesma, B., Amigo, L., Ramos, M., Recio, I. (2004) Angiotensin converting enzyme inhibitory activity in commercial fermented products. Formation of peptides under simulated gastrointestinal digestion. Journal of Agricultural and Food Chemistry, 52: 1504-1510

  13. Hernández-Ledesma. B., García-Nebot, M.J., Fernández-Tomé, S., Amigo, L., Recio, I. (2013) Dairy protein hydrolysates:Peptides for health beneûts. Int. Dairy J., 38:82-100 

  14. Kayser, H., Meisel, H. (1996) Stimulation of human peripheral blood lymphocytes by bioactive pep-tides derived from bovine milk proteins. FEBS Lett., 383:18-20

  15. Kitts, D. D., Weiler, K. (2003) Bioactive proteins and peptide from food sources. Application of bioprocesses used in isolation and recovery. Curr. Pharm. Des., 9:1309-1323

  16. Lacroix, I. M. E., Li-Chan, E. C. Y. (2012) Dipeptidyl peptidase-IV inhibitory activity of dairy protein hydrolysates. International Dairy Journal, 25: 97-102

  17. Lacroix, I. M., Li-Chan, E. C. (2013) Inhibition of dipeptidyl peptidase (DPP)-IV and á-glucosidase activities by pepsin-    treated whey proteins. Journal of agricultural and food chemistry, 61: 7500-7506

  18. Lahov, E., Regelson, W. (1996) Antibacterial and immunostimulating casein-derived substances from milk: casecidin, isracidin peptides. Food Chem. Toxicol., 34: 131-145

  19. LeBlanc, J. G., Matar, C., Valdez, J. C., LeBlanc, J., Perdigon, G. (2002) Immunomodulating effects of peptidic fractions issued from milk fermented with Lactobacillus helveticus. J. Dairy Sci., 85: 2733-2742

  20. Madureira, A. R., Tavares, T., Gomes, M. P., Malcata, F.X. (2010) Physiological Properties of Bioactive Peptides Obtain from Whey Proteins. J Dairy Science, 93:437-455

  21. Meisel, H., Gunther, S. (1998) Food proteins as precursors of peptides modulating human cell activity. Nahrung, 42: 175–176

  22. Moughan, P. J., Fuller, M. F., Han, K. S., Kies, A. K., Miner-Williams, W. (2007) Food-derived bioactive peptides influence gut function. International Journal of Sport Nutrition and Exercise Metabolism, 17: S5-S22

  23. Nagaoka, S., Futamura, Y., Miwa K., Awano, T., Yamauchi, K., Kanamaru, Y., Tadashi, K., Kuwata, T. (2001) “Identification of novel hypocholesterolemic peptides derived from bovine milk 5ØýÞ-lactoglobulin.” Biochemical and Biophysical Research Communications, 28: 11-17

  24. Pedersen, N. L., Nagain-Domaine, C., Mahe, S., Chariot, J., Rozé, C., Tomé, D. (2000) Caseinomacropeptide specifically stimulates exocrine pancreatic secretion in the anesthetized rat. Peptides, 21: 1527-1535

  25. Pfeuffer, M., Schrezenmeir, J. (2000) Bioactive substances in milk with properties decreasing risk of cardiovascular diseases. Br. J. Nutr., 84: S155-159

  26. Phadke, S. M., Deslouches, B., Hileman, S. E., Montelaro, R. C., Wiesenfeld, H. C., Mietzner, T. A. (2005) Antimicrobial peptides in mucosal secretions: the importance of local secretions in mitigating infection. J. Nutr., 135: 1289-1293

  27. Phelan, M., Aisling, A., FitzGerald, R. J., O’Brien, N. M. (2009) Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status. International Dairy Journal, 19:643-654

  28. Power, O., Jakeman, P., Fitzgerald, R. J. (2013) Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides. Amino Acids, 44: 797-820

  29. Ricci-Cabello, I., Olalla Herrera, M., Artacho, R. (2012) Possible role of milk derived bioactive peptides in the treatment and prevention of metabolic syndrome. Nutrition reviews, 70: 241-255

  30. Roy, M. K., Watanabe, Y., Tamai, Y. (1999) Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J. Biosci. Bioeng., 88: 426-432

  31. Shimizu, M., Hachimura, S. (2011) Gut as target for functional food. Trends in Food Science and Technology, 22: 646-650

  32. Slama, G., Elgrably, F., Mbemba, J., Larger, E. (2006) Postprandial glycaemia: a plea for the frequent use of delta postprandial glycaemia in the treatment of diabetic patients. Diabetes Metab., 32: 187-192

  33. Teschemacher, H. (2003) Opioid receptor ligands derived from food proteins. Current Pharmaceutical Design, 9: 1331-1344

  34. Tidona, F., Criscione, A., Guastella, A. M., Zuccaro, A., Bordonaro, S., Marletta, D. (2009) Bioactive peptides in dairy products. Italian Journal of Animal Science, 8: 315-340

  35. Tompa, G., Laine, A., Pihlanto, A., Korhonen, H., Rogelj, I., Marnilab, P. (2010) Chemiluminescence of non-differentiated THP-1 promonocytes: developing an assay for screening anti-inflammatory milk proteins and peptides. Journal of Biological and Chemical Luminiscence, 26: 251-258

  36. Tulipano, G., Sibilia, V., Caroli, A. M., Cocchi, D. (2011) Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors. Peptides, 32: 835-838

  37. Uenishi, H., Kabuki, T., Seto, Y., Serizawa, A., Nakajima, H. (2012) Isolation and dentification of casein-derived dipeptidyl-    peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose inrats. International Dairy Journal, 22: 24-30

  38. Vogel, H. J., Schibli, D.J.,Weiguo, J.,Lohmeier-Vogel, E.M.,Epand, R. F.,Epand, R.M. (2002) Towards a structure-function analysis of bovine lactoferricin and related tryptophan and arginine containing peptides. Biochem. Cell Biol., 80: 49-63

  39. Welderufael, F. T., Gibson, T., Jauregi, P. (2012) Production of angiotensin-I-converting enzyme inhibitory peptides from b-lactoglobulin and casein-derived peptides: an integrative approach. Biotechnology Progress, 28: 746-755

  40. Yamauchi, R., Ohinata, K., Yoshikawa, M. (2003) “5ØýÞ-Lactotensinand neurotensin rapidly reduce serum cholesterol via NT2receptor.” Peptides, 24 : 1955-1961

  41. Zimmermann, M. B., Hurrell, R. F. (2007) Nutritional iron deficiency. Lancet, 370: 511-520


Editorial Board

View all (0)