Asian Journal of Dairy and Food Research, volume 39 issue 2 (june 2020) : 121-125

Magnesium Hydroxide as Curative Strategy against Lactic Acidosis in Goat

M.Q. Koondhar, A.A. Khaskheli, A.A. Jariko
1Department of Animal Nutrition, Sindh Agriculture University, Tandojam-70051, Pakistan.
Cite article:- Koondhar M.Q., Khaskheli A.A., Jariko A.A. (2020). Magnesium Hydroxide as Curative Strategy against Lactic Acidosis in Goat. Asian Journal of Dairy and Food Research. 39(2): 121-125. doi: 10.18805/ajdfr.DR-168.
Lactic acidosis is a metabolic disorder caused by feeding errors. It represents a significant economic loss due to direct as well as indirect effects. In present study a total of twenty four goats were focused in order to observe the efficacy of Magnesium hydroxide against induced lactic acidosis. Goats were divided into two groups viz., A and B. Goats in group A were induced lactic acidosis by offering over feeding of grains, while group B was kept as control and normal diet was provided to the goats. After appearance of clinical signs, goat in group A were treated with Magnesium hydroxide at the dose rate of 1g/Kg body weight on the interval of 24, 48 and 72 hours. Results indicated body temperature, ruminal pH, blood pH, respiration rate and heart rate attained normal level after the treatment with Magnesium hydroxide. Serum biochemical examinations of liver function after induction of lactic acidosis revealed that glucose level (190.14±36.49mg/dl), total bilirubin (0.75±0.04mg/dl), direct bilirubin (0.27±0.03mg/dl), indirect bilirubin (0.40±0.03mg/dl), alanine aminotransferase (36.42±3.04 U/L) and alkaline phosphatase (420±3.65 U/L) were significantly (P<0.05) increased. Magnesium Hydroxide helped in improving the normal physiological parameters but did not improved the rumen and intestinal motility. The hematological examination after the induction of lactic acidosis revealed hemo-concentration and increased Hb% (15.02±1.30) which significantly (P<0.05) became normal within 72hrs after Magnesium hydroxide therapy. Present study concludes that the Magnesium hydroxide is very helpful in minimizing the complications of lactic acidosis in goat, thus may be used as therapy of choice.
  1. Alam, M., Das, B.C., Hassan, M.M, Ahaduzzaman, M, AlFaruk, M.S., Hasanuzzaman, M. (2014). Ruminal acidosis-A case compilation study in SAQ Teaching Veterinary Hospital, Bangladesh. Veterinary World. 7: 2653-2663.
  2. Anderson, D.E., Rings, M. (2008). Current Veterinary Therapy-E-    Book: Food Animal Practice. Elsevier Health Science. 3: 1234-1220.
  3. Arora, N., Tufani, N.A., Kumar, T. (2011). Grain overload in buffalo and its therapeutic management. Intas Polivet. 12: 315-317.
  4. Chakrabarti, A. (2006). Text Book of Clinical Veterinary Medicine 3rd revised and enlarged edition. Kalyani Publishers, New Dehli, 291-295.
  5. Chaudhary, P., Varshney, J., Deshmukh, V. and Desai, S.B. (2009). For the management of bovine acidosis. Intas Polivet. 1: 8-12.
  6. Gonzalez, L., Manteca, A.X., Calsamiglia, S., Schwartzkopf, G.K.S. and Ferret, A. (2012). Ruminal acidosis in feedlot cattle. Interplay between feed ingredients, rumen function and feeding behavior a review. Animal Feed Science and Technology. 1: 66-79.
  7. Gozho, G., Plaizier, N.J.C., Krause, D.O., Kennedy, A.D. and Wittenberg, K.M. (2005). Sub-acute ruminal acidosis induces ruminal lipopolysaccharide release and triggers an inflammatory response. Journal Dairy Science. 88: 1399-1403.
  8. Hernandez, J., Benedito, J.L., Abuelo, A. and Castillo, C. (2014). Ruminal acidosis in feedlot from aetiology to prevention. Pakistan Veterinary Journal. 4: 2823-2831 
  9. Joaquin, H., Jose, L.B., Angel, A. and Cristina, C. (2014). Ruminal acidosis in feedlot from aetiology to prevention. Journal of Agriculture Science. 6: 2134-2142.
  10. Kamra, D.N. (2005). Rumen microbial ecosystem. Current Science. 1: 124-135.
  11. Karapinar, T., Dabak, M., Kizil, O. and Balikci, E. (2008). Severe thiamine deficiency in sheep with acute ruminal lactic acidosis. Journal Veterinary Internal Medicine. 3: 662-    665.
  12. Lascano, G.J. (2011). Optimizing nutrient utilization of a precision feeding system for dairy heifers using low and high forage diets. The Pennsylvania State University.
  13. Long, M., Li, P., Zhang, Y., Chen, X., Gao, Z. and Liu, G. (2016). Evaluation of the protective effect of the acid-tolerant engineered bacterial strain M. elsdenii H6F32 as a probiotic fed to sheep during the lactic acidosis challenge. Indian Journal of Animal Research. 50: 330-334.
  14. Oetzel, G. (2003). Sub-acute ruminal acidosis in dairy cattle. Advance Dairy Cattle. 15: 307-17.
  15. Oliveira, D., Medeiros, M., Assis, J.M.A., Neves, A.C.O., Galiza, A.B, Simoes, G.J.N., Dantas, S.V.D. and Riet-Correa, F. (2009). Acidose lactica ruminal agudaem caprinos. Ciência Animal Brasileira. 6: 117-122.
  16. Penner, G., Beauchemin, B.K.A and Mutsvangwa, T. (2007). Severity of ruminal acidosis in primiparous Holstein cows during the periparturient period. Journal of Dairy Science. 90: 365-375.
  17. Rahman MM (2009). Prevalence and clinical management of carbo hydrate engorgement in goats. Pakistan Veterinary Journal. 6: 2994-3006 
  18. Ram, P.K., Verma, S.P., Agrawal, A.K. and Jayachandran, C. (2007). Effect of severity of acidosis on ruminal activity in goats. Indian Journal of Animal Research. 41: 256-260.
  19. Rodostitis, O., Gay, M.C.C., Blood, D.C. and Hinchkliff, K.W. (2000). Rumen Acidosis. In: Veterinary Medicine, 9th Edition. Saunders Elsevier, London. Pp: 293-303. 
  20. Rodostits, O., Gay, M.C.C, Hinchcliff, K.W. and Constable, P.D (2007). Veterinary Medicine, A textbook of the diseases of cattle, horses, sheep, pigs and goats. Saunders-Elsevier (USA), Pp: 898.
  21. Ullah, H., Khan, A., Khan, J.A., Sadique, M.S., Shah, U., Idrees, M. and Shah, Z. (2013). Clinico-therapeutical trials of lactic acidosis in small ruminants. Journal of Animal and Plant Science. 23: 80-83.
  22. Valente, T.N.P., Sampaio, C.B., Lima, E.D.S., Deminicis, B.B., Cezário, A.S. and Santos, W.B.R.D. (2017). Aspects of acidosis in ruminants with a focus on nutrition: a review. Journal Agriculture Science. 9: 90-97.
  23. Yang, W., Li, Z.Y.L., McAllister, T.A., McKinnon, J.J. and Beauchemin, K.A. (2012). Wheat distillers grains in feedlot cattle diets: Feeding behavior, growth performance, carcass characteristics and blood metabolites. Journal of Animal Science. 4: 1301-1310.

Editorial Board

View all (0)