<div>Eighteen animals with various surgical conditions were divided into three groups of six animals each. Group I received ropivacaine (0.75%) @ 0.25 mg/kg b.wt at sacrococcygeal space. Group II animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and dexmedetomidine at 5 &micro;g/kg b.wt in the sacrococcygeal space. Group III animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and clonidine @ 2 &micro;g/kg b.wt at sacrococcygeal space. The fastest onset of analgesia was produced by ropivacaine-dexmedetomidine combination followed by ropivacaine-clonidine. RT showed non significant decrease in all groups during post epidural analgesia. A non significant increase in RR was observed in cattle following ropivacaine and ropivacaine-clonidine epidural analgesia. Where as a non significant fall in RR was noticed during ropivacaine-dexmedetomidine combination. A non significant increase in HR was recorded after epidural administration of ropivacaine in group I animals. Whereas group II and III animals showed a non significant decrease in HR throughout the period of study. ECG studies did not reveal any abnormalities except sinus arrhymia in all animals. In group I and III non significant increase in Hb and PCV was observed in the present study. Non significant decrease in Hb and PCV values were recorded in animals subjected to ropivacaine-dexmedetomidine analgesia. A non significant increase in AST, ALT was noticed in all groups of animals. The study suggests that dexmedetomidine is a better adjuvant than clonidine in epidural analgesia as far as cardio-respiratory and Haemato-biochemical parameters are concerned.&nbsp;</div>


<div>Comparative evaluation of ropivacaine, ropivacaine- dexmedetomidine and ropivacaine &ndash; clonidine combinations for epidural analgesia in cattle</div>


<p style="text-align:justify">The objective of study was to assess the quality of analgesia and record the alteration in anaesthetic indices following lumbosacral administration of lignocaine alone @ 4 mg/kg body weight in group I and its combination with butorphanol@ 0.04 mgkg body weight in group II. Onset of analgesia in both groups was evident at 5 min and reached to peak level at 15 minutes of observation. The incoordination and sedation was more marked in butorphanol groups as compared to lignocaine groups. The onset of analgesia was delayed in group II as compared to group I, whereas, duration of analgesia and standing time was significantly higher (P&lt;0.05) in group II as compared to group I. Time to recumbency did not revealed significant variation between groups. It is concluded that lignocaine alone and in-combination produced satisfactory onset of analgesia but it remained longer time in lignocaine &ndash; butorphanol group (group II) with respect to duration of analgesia and time to standing. However, this combination also showed the marked sedation and incoordination. Hence, butorphanol in combination with lignocaine was considered better for producing analgesia for longer duration operative procedure.</p>


Comparative evaluation of ropivacaine, ropivacaine- dexmedetomidine and ropivacaine – clonidine combinations for epidural analgesia in cattle

Anaesthetic evaluation of lignocaine alone and in-combination with butorphanol in goats