Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.44

  • SJR .282 (2022)

  • Impact Factor .427 (2022)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Research Article

Comparative evaluation of ropivacaine, ropivacaine- dexmedetomidine and ropivacaine – clonidine combinations for epidural analgesia in cattle

K. Chandra Sekhar, P. Veena, R.V. Suresh Kumar, P. Jagapathi Ramayya
  • Email
1Department of Veterinary Anatomy Department of Veterinary Surgery and Radiology, College of Veterinary Science, Tirupati-517 502, Andhra Pradesh, India.
Cite article:- Sekhar Chandra K., Veena P., Kumar Suresh R.V., Ramayya Jagapathi P. (2019). Comparative evaluation of ropivacaine, ropivacaine- dexmedetomidine and ropivacaine – clonidine combinations for epidural analgesia in cattle. Indian Journal of Animal Research. 54(2): 202-208. doi: 10.18805/ijar.B-3751.

ABSTRACT

Eighteen animals with various surgical conditions were divided into three groups of six animals each. Group I received ropivacaine (0.75%) @ 0.25 mg/kg b.wt at sacrococcygeal space. Group II animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and dexmedetomidine at 5 µg/kg b.wt in the sacrococcygeal space. Group III animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and clonidine @ 2 µg/kg b.wt at sacrococcygeal space. The fastest onset of analgesia was produced by ropivacaine-dexmedetomidine combination followed by ropivacaine-clonidine. RT showed non significant decrease in all groups during post epidural analgesia. A non significant increase in RR was observed in cattle following ropivacaine and ropivacaine-clonidine epidural analgesia. Where as a non significant fall in RR was noticed during ropivacaine-dexmedetomidine combination. A non significant increase in HR was recorded after epidural administration of ropivacaine in group I animals. Whereas group II and III animals showed a non significant decrease in HR throughout the period of study. ECG studies did not reveal any abnormalities except sinus arrhymia in all animals. In group I and III non significant increase in Hb and PCV was observed in the present study. Non significant decrease in Hb and PCV values were recorded in animals subjected to ropivacaine-dexmedetomidine analgesia. A non significant increase in AST, ALT was noticed in all groups of animals. The study suggests that dexmedetomidine is a better adjuvant than clonidine in epidural analgesia as far as cardio-respiratory and Haemato-biochemical parameters are concerned. 

REFERENCES

  1. Ahmad, Rayees and Shukla B P (2013). Haemato-biochemical changes following epidural analgesia by upivacaine, ropivacaine and ropivacaine-xylazine combination in goats. Indian Journal of Field Veterinarians 8(3):47-51.
  2. Aksoy O, Ozaydin I, Ali H, Kirmizigul, Kilic E, Ozturk S, Kurt B, Yayla S, Sozmen M and Atakisi E (2012). Evaluation of experimental subarachnoid analgesia in cows. Veterinarski Arhiv 82(5):463-472. 
  3. Amarpal, Kinjavdekar P, Aithal H P, Singh G R, Pawde A M, Singh T, Sharma A and Pratap K (2007). Comparison of two doses of ropivacaine for lumbosacral epidural analgesia in buffalo calves (Bubalus bubalis).Veterinary Record 160:766-769.
  4. Araujo M A, Albuquerque V B, Deschk M, Santos G G, Rodrigues C A, Oliva V N, and Santos P S (2012). Cardiopulmonary and analgesic effects of caudal epidurally administered ropivacaine in cattle. Veterinary AnaesthesiaAnalgesia 39(4):409-413.
  5. Bishat D S, Jadon N S, Kandpal M and Bodh D (2016). Clinicophysiological and haematobiochemical effects of dexmedetomidine- etomidate-sevoflurane anaesthesia in dogs. Indian Journal of Veterinary Surgery 37(2):77-81.
  6. Hall LW, Clarke KW and Trim CM (2001). General principles of local analgesia. In : Veterinary Anaesthesia, 10th edition. W B Saunders and Co., London pp : 225-244.
  7. Jaiswal A, Pandey S S, Parihar A S, Rajput N and Jain R (2017). Haemato-biochemical alterations after epidural Sadministration of dexmedetomidine alone and in combination with bupivacaine in buffalo calves. Indian Journal of Veterinary Sciences and Biotechnology 12(3):59-61.
  8. Kamble S, Jain R, Shukla B P, Pandey S S, Rajput N and Ganguly S (2016). Haematological alterations after epidural administration of ropivacaine in combination with dexmedetomidine as an epidural analgesia in buffalo calves. International Journal of Medical Research and Pharmaceutical Science 3(6):15-17.
  9. Khattri S, kinjavdekar P, Amarpal, Aithal H P, Pawde A M, Kumar R and Singh J (2013). Dexmedetomidine with butorphanol and propofol for total intravenous anaesthesia in uraemic buffalo calves. Advances in Animal and Veterinary Sciences 1(28):15-23. 
  10. Khajuria A, Fazili M R, Shah R A, Khan F A, Bhat M H, Yaqoob S H, Naykoo N A and Ganai N A (2014). Comparison of two doses of ropivacaine hydrochloride for lumbosacral epidural anaesthesia in goats undergoing laparoscopy assisted embryo transfer. International Scholarly Research Notices ID 937018:1-8. 
  11. Kumar A, Kandpal M and Jadon N S (2016). Clinicophysiological and haematobiochemical effects of dexmedetomidine along with ketamine in dogs. Indian Journal of Veterinary Surgery 37(2):88-92.
  12. Kumari L, Sharma A K, Kumari L and Sinha M P (2017). Haemato-biochemical effects of lumbosacral epidural anaesthesia with ropivacaine and dexmedetomidine in goats. Indian Journal of Small Ruminants 23(1):117-119.
  13. Rafee M A, Kinjavdekar P, Amarpal and Aithal H P (2016). Clinico-physiological and haemodynamic changes during midazolam-ketamine anaesthesia in dogs premedicated with dexmedetomidine with or without pentazocine. Indian Journal of Veterinary Surgery 37(2):82-87. 
  14. Schalm O W , Jain N C and Corrol E J (1975). Veterinary Haematology, Edn., 3rd, Lea and Febiger Philadelphia,pp.45-61.
  15. Singh K, Kinjavdekar P, Amarpal, Aithal H P, Gopinathan A, Singh G R, Singh T, Pawde A M and Pratap K (2005). Clinicophysiological and haematobiochemical effects of epidural ropivacaine in uraemic and healthycaprines. Indian Journal of Veterinary Surgery 32(1):11-15. 
  16. Singh K, Kinjadekar P, Gopinathan A, Aithal H P, Verma M and Amarpal (2015). Comparative evaluation of ropivacaine, bupivacaine and xylazine-ketamine combination for epidural analgesia in goats. Veterinarski Arhiv 85(2):151-162.
  17. Swami S S, Keniya V M, Ladi S D and Rao R (2012). Comparison of dexmedetomidineand clonidine (á2 agonist drugs) as an adjuvant to local anaesthesia in supraclavicular brachial plexus block: A randomized double-blind prospective study. Indian Journal of Anaesthesia 56(3):243-249. 
In this Article
    Contact us
    Follow us

    Editorial Board

    View all (0)