<div>Metabolic syndrome (MS) is a complex condition characterized by insulin resistance, hyperglycemia, dyslipidemia, and obesity. This project aims to induce MS in rat and then a demonstration of the main biochemical parameters. In male, Sprague-Dawley rats, MS has been prompted suitably and relatively by fast (six weeks) approach through a high fructose in drinking water (40%). It has been found that serum urea, creatinine, and total bilirubin raise in MS significantly. Moreover, dyslipidemia has arbitrated via some considerable lipid profile deviations. In addition, BMI, blood glucose, and insulin monitoring evidently ensure achievement of MS. It is concluded that a well-established rat model of MS could be employed by a 40% fructose in drinking water.</div>


<div>Biochemical investigation of an experimentally induced metabolic syndrome in rats</div>


<div style="text-align:justify"><strong>Background:</strong> Hyperlipidemia is the disorder of lipid metabolism, characterized by elevated serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoproteins cholesterol (VLDL-C) and decreased high-density lipoprotein cholesterol (HDL-C). Atherosclerosis is a cardiovascular and fibroproliferative inflammatory disease commonly associated with dyslipidemia.<br />
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<strong>Methods: </strong>The study was conducted using 24 Wistar male rats, divided into two groups of 12 rats each. Hyperlipidemia and atherosclerosis were induced by the addition of 1% cholesterol and 15% saturated oil to the 1000g of standard rat diet and given to group II rats. Group I kept as control and maintained for 90 days.&nbsp;<br />
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<strong>Result: </strong>The present experiment established hyperlipidemia with a significant increase of TC, TG, LDL-C and decreased HDL-C cholesterol with initiated atherosclerotic lesions in the aorta and showed varying degrees of positivity with CD31, CD44, Cadherin and Beta-catenin proteins.</div>


<div style="text-align:justify">Experimentally Induced Hyperlipidemia and Associated Atherosclerosis in the Aorta and Vascular Expression of CD 31, CD44, Beta-catenin and E Cadherin in Wistar Male Rats</div>
