<div><strong>Background: </strong>Copper (Cu), an essential trace element, is toxic if consumed in excessive amounts. Ruminants, particularly sheep, are highly susceptible to chronic copper poisoning and cause acute death. Spontaneous copper poisoning in sheep was reported from many parts of the world however limited reports are available from India. Hence the present investigation was undertaken to report the occurrence of chronic copper poisoning in an intensively maintained Pattanam breed of sheep flock and its therapeutic management.&nbsp;<br />
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<strong>Methods:</strong> An investigation was carried out to ascertain the possible cause of increased mortality in an intensively maintained 130 male lambs aged between 8 to 10 month old belongs to Pattanam breed during the month of September 2020 following death of 21 animals within a period of 15 days. Affected flock was inspected and samples were collected for biochemical analysis, toxicological, bacteriological and pathological examination.<br />
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<strong>Result: </strong>Affected animals showed depression, anorexia, jaundice, hemoglobinurea and accelerated breathing. At necropsy, the dead animals showed generalized icterus, lung edema, yellow to orange coloured liver and gun metal kidney. Histopathological lesions include lung edema, centrilobular hepatic necrosis, bile stasis, renal tubular necrosis and formation of tubular cast. Toxicological analysis of liver revealed the copper level of 781 mg/kg dry matter basis. Source of copper was identified as a commercial mineral mixture supplement intended for cattle was supplemented along with concentrate feed. The flock was treated with chelating agent (D-penicllamine) and supportive therapies.</div>


<div>Spontaneously Occurring Chronic Copper Toxicosis in Pattanam Breed of Sheep</div>


<div>A first lactation dairy cow was presented with the history of accidental consumption of Abrus precatorius seed with clinical signs of blood tinged feces and anorexia since a day. Rumen fluid evaluation revealed sluggish protozoal motility with a pH of 7.0. Hematology revealed moderate reduction in leukocyte count (3.05&times;103/cmm) and total erythrocyte count (4.9&times;106/cmm). Biochemical analysis revealed hypoproteinemia (4.2g /dl), mild Hypocalcemia (ionized calcium- 0.90 mmol/L), hypochloraemia (98 mmol/L) and hyponatremia (131.4 mmol/L). Electrocardiography was unremarkable. Animal treated with supportive care based on fluid therapy with Multielctrolyte solution.</div>


Spontaneously Occurring Chronic Copper Toxicosis in Pattanam Breed of Sheep

Spontaneous clinical toxicosis with Abrus precatorious Seeds in a dairy cow