<div>Background: Aflatoxins (AF) are a major threat in tropical and sub-tropical countries and causes aflatoxicosis in poultry. The deleterious effect of AF are minimised by the addition of various hepatoprotectants. Study was undertaken to find out the effect of Aegle marmelos and Andrographis paniculata on aflatoxicosis of broiler chicken. 
 
Methods: Forty eight day old broiler chicks were divided into eight groups and fed with diets: standard feed (T1), T1 with 100 ppb AF (T2), T1 with 0.1 per cent A. marmelos powder and 0.1 per cent A. paniculata powder (T3), T1 with 100ppb AF and 0.10 per cent A. marmelos powder (T4), T1 with 100ppb AF and 0.10 per cent A. paniculata powder (T5), T1 with 100 ppb AF and 0.20 per cent A. marmelos powder (T6), T1 with 100ppb AF and 0.20 per cent A. paniculata powder (T7) and T1 containing 100 ppb AF, 0.1 per cent A. marmelos powder and 0.1 per cent A. paniculata powder (T8). All the experimental birds were sacrificed on 21st day of the experiment.&nbsp; 
 
Result: Broiler chicks of T2 group showed a significant increase in lipid peroxidation levels compared with other groups at 21st day of experiment. Liver of T2 group of birds revealed the presence of cytoplasmic vacuolations, Kupffer cell hyperplasia, focal accumulation of mononuclear cells and acinar pattern of parenchyma compared to normal histological appearance of T1 and T3 groups. Kidney of T2 birds revealed epithelial degeneration, mononuclear accumulation, desquamation of proximal convoluted tubule and vacuolation of distal convoluted tubule. The hepatoprotective and nephroprotective effect of both plant powders in aflatoxicosis was established.</div>

<div>Hepatoprotective and Nephroprotective Effect of Aegle marmelos and Andrographis paniculata in Aflatoxicosis of Broiler Chicken</div>

<div>Background: Cisplatin is one of the most remarkable solutions in &lsquo;the war on cancer&rsquo;. Although cisplatin has been a mainstay for cancer therapy, its use is mainly limited by nephrotoxicity. The current study was aimed to evaluate the ameliorative potential of Terminalia arjuna (TA) in comparison to taurine against cisplatin toxicity. 
 
Methods: A total of 36 male Wistar rats were divided into 6 groups of 6 rats in each. Group 1 was normal control. Cisplatin @ 5 mg/kg b.wt was injected on day 1 to groups 2, 5 and 6. Aqueous leaf extract of Terminalia arjuna was administered orally @ 400 mg/kg b. wt to groups 3, 5 and Groups 4, 6 recieved taurine orally @ 1000 mg/kg b.wt for 14 days. Blood samples were collected from animals to assess Kidney function tests, oxidative stress and cytokines and renal tissues were examined for histological changes, if any.&nbsp; 
 
Result: Antioxidant profile, serobiochemical and cytokine parameters were significantly (P&lt;0.05) increased and histopathological studies revealed degenerative changes and marked infiltration in the kidney of group 2 when compared to groups 1, 3 and 4. However, These changes were reversed in groups 5 and 6 that were administered with Terminalia arjuna and taurine, respectively. In conclusion, the results of the present investigation elucidated that both Terminalia arjuna and taurine have potent nephroprotective activity in cisplatin injected Wistar rats.</div>

Hepatoprotective and Nephroprotective Effect of Aegle marmelos and Andrographis paniculata in Aflatoxicosis of Broiler Chicken

​Evaluation of Terminalia arjuna in Comparison to Taurine against Experimental Nephrotoxicity due to Cisplatin in Rats

Evaluation of Terminalia arjuna in Comparison to Taurine against Experimental Nephrotoxicity due to Cisplatin in Rats