<div style="text-align: justify;">An ischaemia/reperfusion (I/R) injury in an organ can also cause damage to other organs. In this study, the effects of nizatidine were investigated on ovarian I/R injury and subsequent heart damage in rats. Rats were divided into groups; ovarian I/R (IRG), nizatidine 25 mg/kg+ ovarian I/R (NIR), and control (CG) groups. The NIR and IRG groups were given 2 hours of ischaemia followed by 2 hours of reperfusion by applying, and subsequently releasing, a vascular clip to the right ovarian artery. While oxidant levels in the IRG group were higher than NIR and CG groups, antioxidant levels were lower. Necrosis, congested blood vessels, haemorrhage, leukocyte infiltration and oedema were observed in the ovarian and heart tissues of the IRG group. These findings were reduced in the NIR group. Nizatidine suppressed oxidative stress in ovarian and heart tissues and may be useful in prevention of I/R&ndash;induced ovarian and cardiac injury.</div>

The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

<div><strong>Background:&nbsp;</strong>To investigate the protective effects of vitamin E and methylprednisolone on ischemia and reperfusion testicular injury after testicular torsion and detorsion in West African dwarf (WAD) goats.&nbsp;<br />
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<strong>Methods:&nbsp;</strong>Thirty-two male WAD goats were randomly allocated into four groups (n=8); group A was treated with vitamin E, group B with methylprednisolone, group C with combo-therapy of vitamin E and methylprednisolone and group D was the control. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), total tissue protein (TTP) and catalase (CAT) were assayed while tissue biopsies were harvested for evaluation of degeneration of germinal cells, desquamation in germinal cells, interstitial edema and haemorrhage.&nbsp;<br />
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<strong>Result:&nbsp;</strong>Findings revealed that Vitamin E administered immediately post ligature application significantly (p&lt;0.05) decreased MDA level in groups A and C. Vitamin E monotherapy and its combination with methylprednisolone respectively ameliorated more the cellular damage and histological alterations caused by ischaemia and reperfusion injury. This study, therefor, suggests that vitamin E monotherapy and its combination with methylprednisolone is more beneficial in the management of short and long term ischemia/reperfusion injury respectively.</div>


<p>Evaluation of Combined Effects of Vitamin E and Methylprednisolone in Ischemia and Reperfusion Injury of the Testicle Post Torsion and Detorsion in West African Dwarf Goats</p>
