Irisin, a novel peptide, was first identified in skeletal muscle cells. It is an exercise protein that is secreted into the bloodstream, through which it reached the white adipose tissue, and interacted with an unknown receptor and cause fat destruction by converting the white adipose tissue to brown adipose tissue. The presence of irisin immunoreactivity in porcupine lung and tongue was studied. In lung, irisin immunoreactivity was found in type II pneumocytes, bronchus, bronchioles and blood vessel. Positive irisin immunostaining was also detected in the lamina epithelialis, striated muscle cells and serous glands in porcupine&rsquo;s tongue. The function of locally synthesized irisin is currently unknown. Therefore, further study is required to reveal the precise effect of irisin.

Immunohistochemical distribution of irisin in the lung&nbsp;and tongue of Porcupine (Hystrix cristata)

Background: The aim of this study was to investigate the effects of Cannabidiol on myokine (Irisin), cerebral (BDNF) and cardiac (cTnI) responses in sepsis-induced rats by Cecal Ligation Perforation (CLP) method.&nbsp; 
 
Methods: In this study, 40 adult male Wistar albino rats, aged between 8-10 weeks, were used. 5 groups were created, with 8 rats in each group: Control (C), Sham (S), CLP, CLP+CBD 2.5 mg/kg, CLP+CBD 5 mg/kg group. Rats in groups C and Sham were sacrificed at the end of the 10th hour and intracardiac blood was taken immediately afterwards. In groups CLP, CLP+2.5 mg/kg, CLP+5 mg/kg, intra-abdominal sepsis was induced and at the end of the 10th hour after sepsis occurred with CLP application, rats were sacrificed and intracardiac blood was taken immediately afterwards. Irisin, BDNF and cTnI levels in the serum samples were measured by ELISA method. 
 
Result:&nbsp;In the present study, mean serum irisin, BDNF and levels were determined to be at the lowest level in the CLP group, while cTnI levels were at the highest level (p&lt;0.01). In CLP groups, serum irisin and BDNF levels increased due to CBD addition and the most significant decrease in cTnI levels occurred in 5 mg/kg CBD groups. As a result, it was concluded that CLP may be safe and beneficial when administered at a dose of 5 mg/kg in sepsis-induced rats.

Immunohistochemical distribution of irisin in the lung and tongue of Porcupine (Hystrix cristata)

The Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method