Background: Elevated circulating homocysteine (Hcy) has been proposed to be associated with nonalcoholic fatty liver disease. Hcy is produced as an intermediate during the metabolism of methionine, an essential amino acid obtained from dietary sources. The objective of this study was to investigate the effect of high methionine-intake on the rat liver and to explore the efficacy of Helix aspersa crude extract against the induced liver injury.&nbsp; 
 
Methods: For this purpose, twenty-four rats were divided into four groups: Control, Met (L-Methionine), HAH (Helix aspersa homogenate) and Met-HAH. Then, biochemical parameters were determined in serum, while liver supernatants were used for determination of total protein and malondialdehyde (MDA) levels. Liver injuries were assessed according to Ishak scoring. 
 
Result: High methionine intake induced moderate hyperhomocysteinemia (HHcy), hyperlipidemia, moderate hepatitis, raised significantly liver markers, CRP (C-Reactive Protein) and lipid peroxidation compared to the control group. The combined treatment Met-HAH induced a significant decrease of Hcy, lipid profile, MDA, inflammation and liver markers and attenuated liver injuries.&nbsp;

Ameliorative Effects of Helix aspersa Extract against Liver Injury Induced by High Methionine Intake in Rats