<div>Habitual consumption of raw fruits as well as vegetables can trim down the threat of many diseases. Ginger is consumed globally as a cuisine and herbal medicine. It is rich in pungent phenolic phytochemical substances together called gingerols. 6-Gingerol (1-[4&rsquo;-hydroxy-3&rsquo;-methoxyphenyl]-5-hydroxy-3- decanone) is the chief pharmacologically-active moiety of ginger. Molecularly, gingerol is a relative of capsaicin and piperine, the compounds which are alkaloids, though the bioactive pathways are unconnected. It is normally found as pungent yellow oil in the ginger rhizome, but can also form a low-melting crystalline solid. Previous studies have suggested ample of therapeutic activities including anticancer, anti-inflammation and anti-oxidation. 6-Gingerol has been found to possess anticancer activities via its effect on a variety of biological pathways involved in apoptosis, cell cycle regulation, cytotoxic activity and inhibition of angiogenesis. Thus, due to its efficacy and regulation of multiple targets, as well as its safety for human use, 6-gingerol has received considerable interest as a potential therapeutic agent for the prevention and/or treatment of various diseases. Overall, this review encapsulates different therapeutic and pharmacological facets of 6-gingerol along with its possible mechanism of action.</div>

Pharmacological Aspects of 6-Gingerol: A Review

Background: Ginger (Zingiber officinale) have gained great attention across the globe since ancient times or decades ago to be utilized as a delicacy spice or remedy to promote health and protect from ailments.&nbsp; 
 
Methods: Supplementing ginger and active phytochemical constituents to mammalian species for spicing foods and protecting cells from disorders during stressful conditions.&nbsp; 
 
Result: Supplementing ginger and active phytochemical constituents during stressful conditions might be helpful to overcome the stressors and increase productive and reproductive performances. Mammalian species during stressful conditions as transitional period, pregnancy, peak of lactation, heat stress andbody ailments require ginger and active phytochemical constituents to alleviate stress and promote body function. Ginger plant contains chemical compounds including amaldehyde, gingerol, shogaol and paradol, which are beneficial to the body health and have a wide range of pharmacological properties. Hence, the review article was designed to shed light of ginger and active phytochemical constituents&rsquo; supplementation on promoting health and protecting from disorders in human and animals.

Pharmacological Aspects of 6-Gingerol: A Review

Promising Roles of Zingiber officinale and its Derivatives on Promoting Health and Protecting from Disorders