<div>Most commonly used &alpha;<sub>2</sub>-adrenoceptor agonist shows adverse cardiovascular effects during anaesthesia. They mainly depress the cardiovascular system by provoking vasoconstriction followed by bradycardia. Although &alpha;<sub>2</sub>-adrenoceptor antagonist like atipamezole can reverse these effects along with that they also reverse the sedation and nociception. Concomitant administration of peripherally acting &alpha;<sub>2</sub>-adrenoceptor antagonist MK-467 can reverse the adverse cardiovascular effect of &alpha;<sub>2</sub>-adrenoceptor agonists without affecting the sedation and nociception. MK-467 has been successfully used in different animals like dogs, cats, sheep, horses along with different &alpha;<sub>2</sub>-adrenoceptor agonist drugs. This review aims to summarize the effects of MK-467 on sedation, cardiopulmonary system, the minimum alveolar concentration of different inhalant anaesthetics, plasma drug concentration, plasma glucose and insulin in different animals.</div>


<div>Various Systemic Effects of MK-467, A Peripherally Acting &alpha;<sub>2</sub>-adrenoceptor Antagonist in Different Animal Species: An Overview</div>


Various Systemic Effects of MK-467, A Peripherally Acting α2-adrenoceptor Antagonist in Different Animal Species: An Overview

Various Systemic Effects of MK-467, A Peripherally Acting α₂-adrenoceptor Antagonist in Different Animal Species: An Overview