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Various Systemic Effects of MK-467, A Peripherally Acting α2-adrenoceptor Antagonist in Different Animal Species: An Overview

DOI: 10.18805/ag.R-2065    | Article Id: R-2065 | Page : 348-352
Citation :- Various Systemic Effects of MK-467, A Peripherally Acting α2-adrenoceptor Antagonist in Different Animal Species: An Overview.Agricultural Reviews.2021.(42):348-352
Akash, M. Hoque, Amarpal anant.akash9@gmail.com
Address : Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly, Uttar Pradesh, India.
Submitted Date : 29-07-2020
Accepted Date : 30-09-2020

Abstract

Most commonly used α2-adrenoceptor agonist shows adverse cardiovascular effects during anaesthesia. They mainly depress the cardiovascular system by provoking vasoconstriction followed by bradycardia. Although α2-adrenoceptor antagonist like atipamezole can reverse these effects along with that they also reverse the sedation and nociception. Concomitant administration of peripherally acting α2-adrenoceptor antagonist MK-467 can reverse the adverse cardiovascular effect of α2-adrenoceptor agonists without affecting the sedation and nociception. MK-467 has been successfully used in different animals like dogs, cats, sheep, horses along with different α2-adrenoceptor agonist drugs. This review aims to summarize the effects of MK-467 on sedation, cardiopulmonary system, the minimum alveolar concentration of different inhalant anaesthetics, plasma drug concentration, plasma glucose and insulin in different animals.

Keywords

α2-adrenoceptor agonists Atipamezole Cardiopulmonary system MK-467 Vatinoxan hydrochloride

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