<div style="text-align:justify">Background: Canine pyometra (chronic purulent endometritis) is one of the most important uterine disorder of bitches seeks medical treatment. The hormonal therapies are not much popular among the veterinarians thus needs to exploit some hormonal protocols for this condition. Therefore, the experiment was carried out to study the therapeutic response of antiprogestin and prostaglandin in canine pyometra.&nbsp; 
 
Methods: The experiment was carried out in total 21 bitches affected with pyometra were selected and divided randomly into 3 groups. Animals of control group (TC) were treated with non-hormonal supportive treatment for 7 days. Animals of T1 were received non-hormonal supportive treatment for 7 days similar to TC along with mifepristone @ 3 mg/kg orally BID on day 1, 2 and 8 and Dinoprost in @ 50-200 mcg/kg S/C day 3 to 7. Animals of T2 were treated similar to TC plus mifepristone @ 3 mg/kg orally BID on day 1, 2 and 8 and Misoprostol @ 3 mcg/kg intravaginally twice daily on day 3 to 7. 
 
Result:&nbsp;Therapeutic responses was recorded better in T1 group (100%), followed by T2 (71.43%) and TC (42.86%). The mean TLC values after completion of treatment (day 8) were significantly decreased in T1 and T2. The neutrophil count in different groups T1, T2 and TC was reduced significantly. There was significant decrease in mean concentration of BUN and creatinine on day 8 after treatment in T1 and T2 groups. The mean ALT values decreased significantly in T1 group. However, ALP values decreased significantly in T1 and T2 groups. The mean serum progesterone declined significantly in both the hormone treated groups (T1 and T2). The study can be concluded that therapeutic response of mifepristone with dinoprost tromethamine was found most effective for the treatment of canine pyometra than mifepristone with misoprostol protocol.</div>

Therapeutic Response of Mifepristone with Dinoprost and Misoprostol for Management of Canine Pyometra

<div>Background: Successful medical management of a serious form of Cystic Endometrial Hyperplasia-Pyometra (CEH-P) in a white tiger, with a combination of mifepristone, misoprostol, cloprostenol, cabergoline and enrofloxacin is discussed. 
 
Methods: A 14-year-old white tiger (Panthera tigris) belonging to the Zoological Garden, Thiruvanathapuram showed symptoms of gradual discomfort, dyspepsia and polydipsia for two weeks. There were no signs of oestrus for the previous two months and a serosanguinous vaginal discharge was also noticed. On ultrasonographic examination, uterine sacculations filled with fluid could be found which was suggestive of pyometra. Leukocytosis, neutrophilia, increased level of serum progesterone, anaemia, high ESR, persistent hyperproteinaemia and hyperglobulinaemia were evident on haematological examination. Considering the risks associated with performing OHE in large felids, medical management was planned. A combination of mifepristone, misoprostol, cloprostenol, cabergoline, enrofloxacin and supportive therapy were given along with strict and close monitoring by different experts on site or by utilizing telemedicine communication technologies. Periodic hematological examination, serum biochemistry, progesterone estimation and ultrasonographic evaluation were done to evaluate the progress of treatment. The progesterone values during the period of study ranged from 45.6 ng/ml at the commencement of treatment to a basal level of 0.73 ng/ml towards the end of treatment.&nbsp; 
 
Result: The animal had an uneventful clinical recovery. Considering the risks associated with performing OHE in large felids, medical management can be considered as a valuable option in treating CEH-Pyometra in wild felids. This being the first report of successful medical treatment of CEH-P in a large captive felid with a combination of antiprogestins, prolactin antagonists, prostaglandins and antibiotics, it is suggested that due consideration of such a treatment regimen is of great importance in large felids.</div>

Therapeutic Response of Mifepristone with Dinoprost and Misoprostol for Management of Canine Pyometra

A Novel Protocol for Medical Management of Cystic Endometrial Hyperplasia-Pyometra in White Tiger