PREVENTIVE EFFECT OF LEUCONOSTOC MESENTEROIDES USED AS PROBIOTIC AGENT IN VIVO

A. Rajvanshi*; S. Kulshreshtha; V.K. Nigam1; R.P. Pareek

Indian Journal of Animal Research, volume 46 issue 4 (december 2012) : 385 - 388

PREVENTIVE EFFECT OF LEUCONOSTOC MESENTEROIDES USED AS PROBIOTIC AGENT IN VIVO

A. Rajvanshi*, S. Kulshreshtha, V.K. Nigam1, R.P. Pareek

Affiliations

¹Dept. of Biotechnology, Institute of Advance Science &Technology, NIMS University, Jaipur- 302 005, India

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Cite article:- Rajvanshi* A., Kulshreshtha S., Nigam1 V.K., Pareek R.P. (2025). PREVENTIVE EFFECT OF LEUCONOSTOC MESENTEROIDES USED AS PROBIOTIC AGENT IN VIVO. Indian Journal of Animal Research. 46(4): 385 - 388. doi: .

ABSTRACT

The preventive effect of Leuconostoc mesenteroides, isolated from cucumber, was studied in vivo. There was a reduction in the count of enterobacteria in mice dosed with Leuconostoc mesenteroides after 3 days of feeding trials. Toxicological data of mice serum revealed that the Leuconostoc isolates had anticholesterolaemic effect. Total serum cholesterol of the mice dosed with Leuconostoc isolate was lower (10.16 mg/dl) than the control. Protection of the gastrointestinal tract (GIT) by this isolate was also observed. Histopathological analysis confirmed that partial protection of the GIT in mice dosed with Leuconostoc isolate and simultaneously infected with Escherichia coli. Thus, isolated L. mesenteroides has a good probiotic effect in terms of reduction of enterobacteria in the GIT, anticholesterolaemic effect and protection of lining of GIT.

KEYWORDS

REFERENCES

Aattouri, N. Bouras, M. Tome, D. Marcos, A. and Lemonnier, D. (2002). Oral ingestion of lactic acid bacteria by rats increases lymphocytic proliferation and interferon ã production. Br. J. Nutr. 87: 367 – 373.
Baird, D.M., (1977). Probiotics help boost feed efficiency. Feed stuffs 49: 11 – 12.
Bertazzoni, M.E. Benini, A. Marzotto, M. Hendriks, H. Sbarbati and A. Dellaglio, F. (2001). Preliminary screening of health- promoting properties of new lactobacillus strain: in vitro and in vivo. HEALFO abstracts, Italy.
Casas, I.A., and Dobrogosz, W.J. (2000). Validation of the probiotic concept: Lactobacillus reuteri confers broad- spectrum protection against disease in humans and animals. Microbial. Ecol. Health Dis. 12: 247– 285.
Fuller, R. (1992). Probiotic: The scientific basis. (Ed. R.Fuller.): Chapman and Hall.London
Gilliland S.E., Nelson CR, Maxwell C 1985. Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol. 49: 377 – 381.
Hatcher, G.E., Lambrecht, R.S. (1993). Augmentation of macrophage phagocytic activity by cell-free extracts of selected Lactic Acid Bacteria. J. Dairy Sci. 76 : 2485 – 2492.
Jiang, T. Mustapha, A. and Savaiano, D.A. (1996). Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J. Dairy Sci. 79 : 750 – 757.
Kekkonen, R.A., Kajasto, E. Miettinen, M. Veckman, V. Korpela, R. and Julkunen, I. (2008). Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-ã production. World J Gastroenterol. 14 : 1192–1203.
Mitsuoka, T., (1992). The human gastrointestinal tract. In Wood, B.J.B. (Ed) The lactic acid Bacteria in health and disease. Elsevier Applied Science, London, pp. 69 – 144.
Oyetayo, V.O., Osho, B. (2004). Assessment of probiotic properties of a strain of Lactobacillus plantarum isolated from fermenting corn slurry (Ogi). Food, Agricul. & Environ. 2 : 132-134.
Oyetayo, V.O., Adetuyi, F.C. and Akinyosoye, F.A. (2003). Safety and protective effect of Lactobacillus acidophilus and Lactobacillus casei used as Probiotic agent in vivo. African J. Biotechnol. 2 : 448-452.
Sandine, W.E. (1979). Role of lactobacillus in the intestinal tract. J. Food Protect. 42: 259 – 262.
Silva, A.M., Bambirra, E.A., Oliveira, A.L., Souza, P.P, Gomes, D.A. Vieira, E.C. and Nicoli JR. (1999). Protective effect of bifidus milk on the experimental infection with Salmonella enteritidis subsp. typhimurium in conventional and gnotobiotic mice. J. Appl. Microbiol. 86: 331 – 336.
Van der Waaij D., Horstra, H. and Wiegersma, N.(1982). Effect of â-lactam antibiotics on the resistance of the digestive tract to colonisation. J. Infect. Dis. 146: 417 – 422.

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[
aattouri_2002] Aattouri, N. Bouras, M. Tome, D. Marcos, A. and Lemonnier, D. (2002). Oral ingestion of lactic acid bacteria by rats increases lymphocytic proliferation and interferon ã production. Br. J. Nutr. 87: 367 – 373.

[2] Baird, D.M., (1977). Probiotics help boost feed efficiency. Feed stuffs 49: 11 – 12.

[3] Bertazzoni, M.E. Benini, A. Marzotto, M. Hendriks, H. Sbarbati and A. Dellaglio, F. (2001). Preliminary screening of health- promoting properties of new lactobacillus strain: in vitro and in vivo. HEALFO abstracts, Italy.

[4] Casas, I.A., and Dobrogosz, W.J. (2000). Validation of the probiotic concept: Lactobacillus reuteri confers broad- spectrum protection against disease in humans and animals. Microbial. Ecol. Health Dis. 12: 247– 285.

[5] Fuller, R. (1992). Probiotic: The scientific basis. (Ed. R.Fuller.): Chapman and Hall.London

[6] Gilliland S.E., Nelson CR, Maxwell C 1985. Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol. 49: 377 – 381.

[7] Hatcher, G.E., Lambrecht, R.S. (1993). Augmentation of macrophage phagocytic activity by cell-free extracts of selected Lactic Acid Bacteria. J. Dairy Sci. 76 : 2485 – 2492.

[8] Jiang, T. Mustapha, A. and Savaiano, D.A. (1996). Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J. Dairy Sci. 79 : 750 – 757.

[9] Kekkonen, R.A., Kajasto, E. Miettinen, M. Veckman, V. Korpela, R. and Julkunen, I. (2008). Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-ã production. World J Gastroenterol. 14 : 1192–1203.

[10] Mitsuoka, T., (1992). The human gastrointestinal tract. In Wood, B.J.B. (Ed) The lactic acid Bacteria in health and disease. Elsevier Applied Science, London, pp. 69 – 144.

[11] Oyetayo, V.O., Osho, B. (2004). Assessment of probiotic properties of a strain of Lactobacillus plantarum isolated from fermenting corn slurry (Ogi). Food, Agricul. & Environ. 2 : 132-134.

[12] Oyetayo, V.O., Adetuyi, F.C. and Akinyosoye, F.A. (2003). Safety and protective effect of Lactobacillus acidophilus and Lactobacillus casei used as Probiotic agent in vivo. African J. Biotechnol. 2 : 448-452.

[13] Sandine, W.E. (1979). Role of lactobacillus in the intestinal tract. J. Food Protect. 42: 259 – 262.

[14] Silva, A.M., Bambirra, E.A., Oliveira, A.L., Souza, P.P, Gomes, D.A. Vieira, E.C. and Nicoli JR. (1999). Protective effect of bifidus milk on the experimental infection with Salmonella enteritidis subsp. typhimurium in conventional and gnotobiotic mice. J. Appl. Microbiol. 86: 331 – 336.

[15] Van der Waaij D., Horstra, H. and Wiegersma, N.(1982). Effect of â-lactam antibiotics on the resistance of the digestive tract to colonisation. J. Infect. Dis. 146: 417 – 422.

Indian Journal of Animal Research

PREVENTIVE EFFECT OF LEUCONOSTOC MESENTEROIDES USED AS PROBIOTIC AGENT IN VIVO

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