volume 44 issue 3 (september 2010) : 168 - 172
EVALUATION OF ANTIDIABETIC EFFICACY OF COCCINIA INDICA IN RATS
1College of Veterinary and Animal Sciences,
Mannuthy-680 651, India
ABSTRACT
The present study was aimed to assess the hypoglycaemic, hypolipidemic and antioxidant
activities of a common herb, Coccinia indica. The study was conducted in Sprague-Dawley
strain of albino rats and the chemical, alloxan was used for the experimental induction of diabetes.
Thirty two adult albino rats were divided into four groups of eight each. Group I served as
normal control and group II was made as diabetic control. Group III and IV were made diabetic
and administered orally with 200 mg/kg of ethanolic extract of C. indica leaves and 0.25 mg/kg
of glibenclamide, respectively, for 45 days. There was a significant (p
activities of a common herb, Coccinia indica. The study was conducted in Sprague-Dawley
strain of albino rats and the chemical, alloxan was used for the experimental induction of diabetes.
Thirty two adult albino rats were divided into four groups of eight each. Group I served as
normal control and group II was made as diabetic control. Group III and IV were made diabetic
and administered orally with 200 mg/kg of ethanolic extract of C. indica leaves and 0.25 mg/kg
of glibenclamide, respectively, for 45 days. There was a significant (p
REFERENCES
- Alagesaboopathi (2009). Afr. J. Trad. CAM 6(3): 222-227.
- Carroll, N.V. et al. (1956). J. Bio. Chem. 220:583-593.
- Chaturvedi, P. and Segale, M. (2007). Scientific Res. and Assay. 2:384-389.
- Geetha, T. et al. (1998). Pharmacological Res. 37:191-195.
- Harbone, J. B. (1991). Phytochemical Methods- Techniques of Plant Analysis. 2nd Ed. Chapman and Hall, India,
- 653p.
- Hyvarien, A and Nikila, E.A. (1962). Clin. Chem. Acta 7:140
- Lu, H. et al. (2009). J. Ethnopharmacol. 122:486-491.
- Moron, M.S. et al. (1979) . Biochem. Biophys. Acta. 582:67-78.
- 172 INDIAN JOURNAL OF ANIMAL RESEARCH
- OECD (2001). Test Guideline 423. OECD Guideline for Testing Acute Oral Toxicity of Chemicals. Available at http://
- iccvam.niehs.nih.gov/SuppDocs/FedDocs/OECD/OECD_GL423.pdf
- Ogbonnia, et al. (2008). African J. Biotech. 7: 2998-3003.
- Ohkawa, H. et al. (1979). Anal Biochem. 95: 351-358.
- Pari, L. and Venkateswaran, S. (2003) Pharmazie. 58(6): 409-412
- Ravi, K. et al. (2004). Life Sci. 75:2717-2731.
- Sakurai, T. et al. (2002). Med. Chem. Lett. 12:807-810.
- Shaheen et al. (2009) Afr. J. Biotechnol. 8(24): 7073-7076.
- Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods. 8th Ed.: Iowa University Press, Ames, Iowa. 584p.
- Turner, R.A. (1965). Screening Methods in Pharmacology. Academic Press, London. 61p.
- Veerapan, A. et al. (2007). Phytomedicine. 14:209-215.
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Indian Journal of Animal Research
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