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volume 44 issue 3 (september 2010) : 168 - 172

EVALUATION OF ANTIDIABETIC EFFICACY OF COCCINIA INDICA IN RATS

E
Eliza Jose
P
P.T.A Usha
*
*
1College of Veterinary and Animal Sciences, Mannuthy-680 651, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Jose Eliza, Usha P.T.A, * (2025). EVALUATION OF ANTIDIABETIC EFFICACY OF COCCINIA INDICA IN RATS. Indian Journal of Animal Research. 44(3): 168 - 172. doi: .

ABSTRACT

The present study was aimed to assess the hypoglycaemic, hypolipidemic and antioxidant
activities of a common herb, Coccinia indica. The study was conducted in Sprague-Dawley
strain of albino rats and the chemical, alloxan was used for the experimental induction of diabetes.
Thirty two adult albino rats were divided into four groups of eight each. Group I served as
normal control and group II was made as diabetic control. Group III and IV were made diabetic
and administered orally with 200 mg/kg of ethanolic extract of C. indica leaves and 0.25 mg/kg
of glibenclamide, respectively, for 45 days. There was a significant (p

REFERENCES

  1. Alagesaboopathi (2009). Afr. J. Trad. CAM 6(3): 222-227.
  2. Carroll, N.V. et al. (1956). J. Bio. Chem. 220:583-593.
  3. Chaturvedi, P. and Segale, M. (2007). Scientific Res. and Assay. 2:384-389.
  4. Geetha, T. et al. (1998). Pharmacological Res. 37:191-195.
  5. Harbone, J. B. (1991). Phytochemical Methods- Techniques of Plant Analysis. 2nd Ed. Chapman and Hall, India,
  6. 653p.
  7. Hyvarien, A and Nikila, E.A. (1962). Clin. Chem. Acta 7:140
  8. Lu, H. et al. (2009). J. Ethnopharmacol. 122:486-491.
  9. Moron, M.S. et al. (1979) . Biochem. Biophys. Acta. 582:67-78.
  10. 172 INDIAN JOURNAL OF ANIMAL RESEARCH
  11. OECD (2001). Test Guideline 423. OECD Guideline for Testing Acute Oral Toxicity of Chemicals. Available at http://
  12. iccvam.niehs.nih.gov/SuppDocs/FedDocs/OECD/OECD_GL423.pdf
  13. Ogbonnia, et al. (2008). African J. Biotech. 7: 2998-3003.
  14. Ohkawa, H. et al. (1979). Anal Biochem. 95: 351-358.
  15. Pari, L. and Venkateswaran, S. (2003) Pharmazie. 58(6): 409-412
  16. Ravi, K. et al. (2004). Life Sci. 75:2717-2731.
  17. Sakurai, T. et al. (2002). Med. Chem. Lett. 12:807-810.
  18. Shaheen et al. (2009) Afr. J. Biotechnol. 8(24): 7073-7076.
  19. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods. 8th Ed.: Iowa University Press, Ames, Iowa. 584p.
  20. Turner, R.A. (1965). Screening Methods in Pharmacology. Academic Press, London. 61p.
  21. Veerapan, A. et al. (2007). Phytomedicine. 14:209-215.
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    volume 44 issue 3 (september 2010) : 168 - 172

    EVALUATION OF ANTIDIABETIC EFFICACY OF COCCINIA INDICA IN RATS

    E
    Eliza Jose
    P
    P.T.A Usha
    *
    *
    1College of Veterinary and Animal Sciences, Mannuthy-680 651, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Jose Eliza, Usha P.T.A, * (2025). EVALUATION OF ANTIDIABETIC EFFICACY OF COCCINIA INDICA IN RATS. Indian Journal of Animal Research. 44(3): 168 - 172. doi: .

    ABSTRACT

    The present study was aimed to assess the hypoglycaemic, hypolipidemic and antioxidant
    activities of a common herb, Coccinia indica. The study was conducted in Sprague-Dawley
    strain of albino rats and the chemical, alloxan was used for the experimental induction of diabetes.
    Thirty two adult albino rats were divided into four groups of eight each. Group I served as
    normal control and group II was made as diabetic control. Group III and IV were made diabetic
    and administered orally with 200 mg/kg of ethanolic extract of C. indica leaves and 0.25 mg/kg
    of glibenclamide, respectively, for 45 days. There was a significant (p

    REFERENCES

    1. Alagesaboopathi (2009). Afr. J. Trad. CAM 6(3): 222-227.
    2. Carroll, N.V. et al. (1956). J. Bio. Chem. 220:583-593.
    3. Chaturvedi, P. and Segale, M. (2007). Scientific Res. and Assay. 2:384-389.
    4. Geetha, T. et al. (1998). Pharmacological Res. 37:191-195.
    5. Harbone, J. B. (1991). Phytochemical Methods- Techniques of Plant Analysis. 2nd Ed. Chapman and Hall, India,
    6. 653p.
    7. Hyvarien, A and Nikila, E.A. (1962). Clin. Chem. Acta 7:140
    8. Lu, H. et al. (2009). J. Ethnopharmacol. 122:486-491.
    9. Moron, M.S. et al. (1979) . Biochem. Biophys. Acta. 582:67-78.
    10. 172 INDIAN JOURNAL OF ANIMAL RESEARCH
    11. OECD (2001). Test Guideline 423. OECD Guideline for Testing Acute Oral Toxicity of Chemicals. Available at http://
    12. iccvam.niehs.nih.gov/SuppDocs/FedDocs/OECD/OECD_GL423.pdf
    13. Ogbonnia, et al. (2008). African J. Biotech. 7: 2998-3003.
    14. Ohkawa, H. et al. (1979). Anal Biochem. 95: 351-358.
    15. Pari, L. and Venkateswaran, S. (2003) Pharmazie. 58(6): 409-412
    16. Ravi, K. et al. (2004). Life Sci. 75:2717-2731.
    17. Sakurai, T. et al. (2002). Med. Chem. Lett. 12:807-810.
    18. Shaheen et al. (2009) Afr. J. Biotechnol. 8(24): 7073-7076.
    19. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods. 8th Ed.: Iowa University Press, Ames, Iowa. 584p.
    20. Turner, R.A. (1965). Screening Methods in Pharmacology. Academic Press, London. 61p.
    21. Veerapan, A. et al. (2007). Phytomedicine. 14:209-215.
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