Indian Journal of Agricultural Research

  • Chief EditorT. Mohapatra

  • Print ISSN 0367-8245

  • Online ISSN 0976-058X

  • NAAS Rating 5.60

  • SJR 0.293

Frequency :
Bi-monthly (February, April, June, August, October and December)
Indexing Services :
BIOSIS Preview, ISI Citation Index, Biological Abstracts, Elsevier (Scopus and Embase), AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Agricultural Research, volume 50 issue 3 (june 2016) : 199-205

Moringa oleifera: A new challenge reducing heavy metal toxicity: A review

Kanitta Jiraungkoorskul, Wannee Jiraungkoorskul*
1<p>Department of Pathobiology, Faculty of Science,&nbsp;Mahidol University, Bangkok 10400, Thailand.</p>
Cite article:- Jiraungkoorskul Kanitta, Jiraungkoorskul* Wannee (2016). Moringa oleifera: A new challenge reducing heavy metal toxicity: A review . Indian Journal of Agricultural Research. 50(3): 199-205. doi: 10.18805/ijare.v0iOF.9361.

Various parts of Moringa oleifera i.e., fruit, seed, leave, flower, bark, and root, have been used extensively in traditional medicine. One of these usages is the reducing of heavy metal toxicity. The mechanism of metal removal property by using the characteristic of its surface morphology and functional groups to uptake the heavy metal. Moreover this plant reduced the metal toxicity in living organism by its antioxidant properties. The advantage utilization of this plant is very interesting as it can easily be cultivated worldwide. Its biosorbent properties are inexpensive, availability, profitability easy of operation, effectiveness in reducing the concentration of heavy metal ions to very low levels. Besides, this plant is reported to have various chemical constituents that have the biological activities including the depletion of metal concentration and the antioxidant properties that are potential to reduce the oxidative stress induced by heavy metal.

  1. Akunna, G.G., Ogunmodede, O.S., Saalu, C.L., Ogunlade, B., Bello, A.J. and Salawu, E.O. (2012). Ameliorative effect of Moringa oleifera (drumstick) leaf extracts on chromium-induced testicular toxicity in rat testes. World J. Life Sci. Med. Res. 2: 20-26.

  2. Alhakmani, F., Kumar, S. and Khan, S.A. (2013). Estimation of total phenolic content, in-vitro antioxidant and anti-    inflammatory activity of flowers of Moringa oleifera. Asian Pac. J. Trop. Biomed. 3: 623–627. 

  3. Ali, H., Khan, E. and Sajad, M.A. (2013). Phytoremediation of heavy metal - Concepts and applications. Chemosphere 91: 869-881.

  4. Araújo, C.S.T., Melo, E.I., Alves, V.N. and Coelho, N.M.M. (2010). Moringa oleifera Lam. seeds as a natural solid adsorbent for removal of AgI in aqueous solutions. J. Braz. Chem. Soc. 21: 1727-1732.

  5. Araújo, C.S.T., Carvalho, D.C., Rezende, H.C., Almeida, I.L.S., Coelho, L.M., Coelho, N.M.M., Marques, T.L. and Alves, V.N. (2013). Bioremediation of waters contaminated with heavy metals using Moringa oleifera seeds as biosorbent. Intech 227-255.

  6. Bakre, A.G., Aderibigbe, A.O. and Ademowo, O.G. (2013). Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice. J. Ethnopharmacol. 149: 783–789.

  7. Bennett, R.N., Mellon, F.A., Foidl, N., Pratt, J.H., Dupont, M.S., Perkins, L. and Kroon, A. (2003). Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L. J. Agric. Food Chem. 51: 3546-3553.

  8. Bhatti, H.N., Mumtaz, B., Hanif, M.A. and Nadeem, R. (2007). Removal of Zn(II) ions from aqueous solution using Moringa oleifera Lam. (horseradish tree) biomass. Process Biochem. 42: 547–553.

  9. Choudhary, M.K., Bodakhe, S.H. and Gupta, S.K. (2013). Assessment of the antiulcer potential of Moringa oleifera root-    bark extract in rats. J. Acupunct. Meridian Stud. 6: 214-220.

  10. Compaoré, W.R., Nikièma, P.A., Bassolé, H.I.N., Savadogo, A., Mouecoucou, J., Hounhouigan, D.J. and Traoré, S.A. (2011). Chemical composition and antioxidative properties of seeds of Moringa oleifera and pulps of Parkia biglobosa and Adansonia digitata commonly used in food fortification in Burkina Faso. Curr. Res. J. Biol. Sci. 3: 64-72.

  11. Coppin, J.P., Xu, Y., Chen, H., Pan, M.H., Ho, C.T., Juliani, R., Simon, J.E. and Wu, Q. (2013). Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera. J. Func. Foods 5: 1892-1899.

  12. Fahey, J.W. (2005). Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for Life J. 1: 5.

  13. Flora, S.J.S. (2009). Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid. Med. Cell Longev. 2: 191-206.

  14. Flora, S.J.S. and Pachauri, V. (2010). Chelation in metal intoxication. Int. J. Environ. Res. Publ. Health 7: 2745-2788.

  15. Fu, F., Xie, L., Tang, B., Wang, Q. and Jiang, S. (2012). Application of a novel strategy - Advanced Fenton-chemical precipitation to the treatment of strong stability chelated heavy metal containing wastewater. Chem. Eng. J. 189–    190: 283-287.

  16. Gassenschmidt, U., Jany, K.K., Tauscher, B. and Niebergall, H. (1995). Isolation and characterization of a flocculating protein from Moringa oleifera lam. Biochem. Biophy. Acta 1243: 477-481.

  17. Ghasi, S., Nwobodo, E. and Ofili, J.O. (2000). Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. J. Ethnopharmacol. 69: 21–25.

  18. Grabow, W.O.K., Slabert, J.L., Morgan, W.S.G. and Jahn, S.A.A. (1985). Toxicity and mutagenicity evaluation of water coagulated with Moringa oleifera seeds preparations using fish, protozoan, bacterial, enzyme and Ames Salmonella assays. J. Am. Water Works Assoc. 76: 319–321.

  19. Gupta, R., Kannan, G.M., Sharma, M. and Flora, S.J.S. (2005). Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats. Environ. Toxicol. Pharmacol. 20: 456–464.

  20. Hamza, A.A. (2010). Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem. Toxicol. 48: 345–355.

  21. Horwath, M. and Benin, V. (2011). Theoretical investigation of a reported antibiotic from the ‘‘Miracle Tree’’ Moringa oleifera. Comp. Theor. Chem. 965: 196–201.

  22. Inaba, T., Kobayashi, E., Suwazono, Y., Uetani, M., Oishi, M., Nakagawa, H. and Nogawa, K. (2005). Estimation of cumulative cadmium intake causing itai-itai disease. Toxicol. Lett. 159: 192-201.

  23. Ivanova, J., Gluhcheva, Y., Tsanova, D., Piskova, A., Djaleva, R., Mokresheva, S., Kamenova, D. and Mitewa, M. (2013). On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview. Eur. J. Chem. 4: 74-84.

  24. Jaiswal, D., Rai, P.K., Mehta, S. Chatterji, S., Shukla, S., Rai, D.K., Sharma, G., Sharma, B., Khair, S. and Watal, G. (2013). Role of Moringa oleifera in regulation of diabetes-induced oxidative stress. Asian Pac. J. Trop. Med. 6: 426-432.

  25. Jarup, L. (2003). Hazards of heavy metal contamination. Br. Med. Bull. 68: 167-182.

  26. Kalavathy, M.H. and Miranda, L.R. (2012). Moringa oleifera - A solid phase extractant for the removal of copper, nickel and zinc from aqueous solutions. Chem. Eng. J. 158: 188–199.

  27. Kita, G. and Skoblewski, P. (2010). Biosorption of heavy metal – Modern and cheap method of polluted wastewater treatment. Food Chem. Biotechnol. 74: 99-105.

  28. Kumari, P., Sharma, P., Srivastava, S. and Srivastava, M.M. (2006). Biosorption studies on shelled Moringa oleifera Lamarck seed powder: removal and recovery of arsenic from aqueous system. Int. J. Min. Pro. 78: 131-139.

  29. Kumbhare, M.R., Guleha, V. and Sivakumar, T. (2012). Estimation of total phenolic content, cytotoxicity and in–vitro antioxidant activity of stem bark of Moringa oleifera. Asian Pac. J. Trop. Dis. 2: 144-150.

  30. Lee, I.H., Kuan, Y.C. and Chern, J.M. (2007). Equilibrium and kinetics of heavy metal ion exchange. J. Chin. Ins. Chem. Eng. 38: 71-84.

  31. Lian, F.W. and Jian, Z.H. (1994). Chronic arsenism for drinking water in some areas of Xingjian, China. In: Nriagu, J.O. (Ed.), Arsenic in the Environment. Part II: Human Health and Ecosystem Effects. John Wiley & Sons Inc., New York, pp. 159–72.

  32. Lone, M.I., He, Z.L., Stoffella, P.J. and Yang, X. (2008). Phytoremediation of heavy metal polluted soils and water: Progresses and perspectives. J. Zhejiang Univ. Sci. B 9: 210–220. 

  33. Mahmood, K.T., Mugal, T. and Haq, I.U. (2010.) Moringa oleifera: A natural gift-A review. J. Pharm. Sci. Res. 2:775-781.

  34. Mandal, B.K., Biswas, B.K., Dhar, R.K., Roy Chowdhury, T., Samanta, G., Basu, G.K., Chanda, C.R., Saha, K.C., Kabir, S., Roy, S. and Chakraborti, D. (1999). Ground water arsenic contamination and suffering of people in West Bengal, India and Bangladesh: Status report up to March 1998. In: Sarkar, B. (Ed.), Metal and Genetics. Plenum Corporation, New York, pp. 41–66.

  35. Marques, T.L., Alves, V.N., Coelho, L.M. and Coelho, N.M.M. (2012). Removal of Ni (II) from aqueous solution using Moringa oleifera seeds as a bioadsorbent. Water Sci. Technol. 68: 1435-1440.

  36. Mohsen-Nia, M., Montazeri, P. and Modarress, H. (2007). Removal of Cu2+ and Ni2+ from wastewater with a chelating agent and reverse osmosis processes. Desalination 217: 276-281.

  37. Ndabigengesere, A., Narasiah, S. and Talbot, B.G. (1995). Active agents and mechanism coagulation of turbid waters using Moringa oleifera. Water Res. 29: 703-10.

  38. Nkurunziza, T., Nduwayezu, J.B., Banadda, E.N. and Nhapi, I. (2009). The effect of turbidity levels and Moringa oleifera concentration on the effectiveness of coagulation in water treatment. Water Sci. Technol. 59: 1551–1558.

  39. Obuseng, V., Nareetsile, F. and Kwaambwa, H.M. (2012). A study of the removal of heavy metals from aqueous solutions by Moringa oleifera seeds and amine-based ligand 1,4- bis[N,N-bis(2-picoyl)amino]butane. Anal. Chem. Acta 730: 87-92.

  40. Ouedraogo, M., Lamien-Sanou, A., Ramde, N., Ouedraogo, A.S., Ouedraogo, M., Zongo, S.P., Goumbri, O., Duez, P. and Guissou, P.I. (2013). Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits. Exp. Toxicol. Pathol. 65: 335-339.

  41. Paliwal, R., Sharma, V. and Janmeda, P. (2011). A review on horse radish tree (Moringa oleifera): A multipurpose tree with high economic and commercial importance. Asian J. Biotechnol. 3: 317-328.

  42. Panda, S., Kar, A., Sharma, P. and Sharma, A. (2013). Cardioprotective potential of N,á-l-rhamnopyranosyl vincosamide, an indole alkaloid, isolated from the leaves of Moringa oleifera in isoproterenol induced cardiotoxic rats: In vivo and in vitro studies. Bioorganic Med. Chem. Lett. 23: 959-962.

  43. Parrotta, J.A. (2009). Moringa oleifera Lam., 1785. Enzyklopädie der Holzgewächse, Handbuch und Atlas der Dendrologie. A. Roloff, H. Weisgerber, U. Lang, B. Stimm. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 

  44. Pritchard, M., Craven, T., Mkandawire, T., Edmondson, A.S. and O’Neill, J.G. (2010). A comparison between Moringa oleifera and chemical coagulants in the purification of drinking water – An alternative sustainable solution for developing countries. Phys. Chem. Earth 35: 798–805.

  45. Rai, U.N. and Pal, A. (2002). Health hazards of heavy metals. Ar. EnviroNews 8(1).

  46. Ravikumar, K. and Sheeja, A.K. (2013). Heavy metal removal from water using Moringa oleifera seed coagulant and double filtration. Int. J. Sci. Eng. Res. 4: 10-13.

  47. Reddy, D.H.K., Harinatha, Y., Seshaiaha, K. and Reddy, A.V.R. 2010. Biosorption of Pb(II) from aqueous solutions using chemically modified Moringa oleifera tree leaves. Chem. Eng. J. 162: 626–634.

  48. Reddy, D.H.K., Ramana, D.K.V., Seshaiah, K. and Reddy, A.V.R. (2011). Biosorption of Ni(II) from aqueous phase by Moringa oleifera bark, a low cost biosorbent. Desalination 268: 150–157.

  49. Sharma, P., Kumari, P., Srivastava, M.M. and Srivastava, S. (2006). Removal of cadmium from aqueous system by shelled Moringa oleifera Lam seed powder. Bioresour. Technol. 97: 299–305.

  50. Sharma, P., Kumari, P., Srivastava, M.M. and Srivastava, S. (2007). Ternary biosorption studies of Cd(II), Cr(III) and Ni(II) on shelled Moringa oleifera seeds. Bioresour. Technol. 98: 474–477.

  51. Sirimongkolvorakul, S., Tansatit, T., Preyavichyapugdee, N., Kosai, P., Jiraungkoorskul, K. and Jiraungkoorskul, W. (2012). Efficiency of Moringa oleifera dietary supplement reducing lead toxicity in Puntius altus. J. Med. Plants Res. 6: 187-194. 

  52. Sirimongkolvorakul, S., Jiraungkoorskul, W., Tansatit, T., Preyavichyapugdee, N., Kosai, P. and Uakulwarwat, K. (2013). Influence of Moringa oleifera on histopathological changes due to lead-toxicity in red-tail tinfoil barb, Puntius altus. Fresenius Environ. Bull. 22: 1946-1950.

  53. Smith, A.H., Lingas, E.O. and Rahman, M. (2000). Contamination of drinking water of arsenic in Bangladesh. Bull. World Health Organ. 78: 1093–1103.

  54. Sreelatha, S., Jeyachitra, A. and Padma, P.R. (2011). Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food Chem. Toxicol. 49: 1270-1275.

  55. Sun, L., Miznikov, E., Wang, L. and Adin, A. (2009). Nickel removal from wastewater by electroflocculation-filtration hybridization. Desalination 249: 832-836.

  56. Tahiliani, P. and Kar, A. (2000). Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol. Res. 41: 319-323.

  57. United States Department of Agriculture, USDA. (2000). Heavy metal soil contamination. Soil quality-Urban technical note No.3, pp.1-7.

  58. United States Department of Agriculture, USDA. (20130. Moringa oleifera Lam. Plants Database. Natural Resources Conservation Service. 

  59. Verma, A.R., Vijayakumar, M., Mathela, C.S. and Rao, C.V. (2009). In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves. Food Chem. Toxicol. 47: 2196–2201.

  60. Vongsak, B., Sithisarn, P., Mangmool, S., Thongpraditchote, S., Wongkrajang, Y. and Grit-sanapan, W. (2013). Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Ind. Crop Prod. 44: 566–571.

  61. Yang, C.Y., Chang, C.C., Tsai, S.S., Chaung, H.Y., Ho, C.K. and Wu, T.N. (2003). Arsenic in drinking water and adverse pregnancy outcome in an arseniasis endemic area in Northeastern Taiwan. Environ. Res. 91: 29–34.

  62. Yorifuji, T., Tsuda, T., Inoue, S., Takao, S. and Harada, M. (2011). Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan. Environ. Int. 37: 907-913.

Editorial Board

View all (0)