Brahmi (Bacopa monnieri): Up-to-date of memory boosting medicinal plant: A review

DOI: 10.18805/ijare.v50i1.8582    | Article Id: A-202 | Page : 1-7
Citation :- Brahmi (Bacopa monnieri): Up-to-date of memory boostingmedicinal plant: A review .Indian Journal Of Agricultural Research.2016.(50):1-7

Natthawut Charoenphon,  Nanthida Anandsongvit1,  Piya Kosai,  Kanjana Sirisidthi, Niwat Kangwanrangsan and Wannee Jiraungkoorskul*

pathobiologymu@gmail.com
Address :

Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Submitted Date : 19-10-2015
Accepted Date : 22-12-2015

Abstract

Bacopa monnieri, Family: Plantaginaceae, known as water hyssop, herb of grace or Indian penny wort, is one of the traditional medicinal plants in Ayurveda medicine, where it is also called Brahmi, a name derived from Brahma, the creator God of the Hindu Pantheon. It is now being widely promoted to enhance memory, learning and concentration and also to treat anxiety, depression, and systemic disorders like cardiovascular, gastrointestinal, hepatic, neurological and also respiratory problems. Further, Brahmi has been shown to possess anticancer, antidiabetic, anti-inflammatory, antimicrobial and antioxidant properties. Its phytochemical substances are alkaloids, flavonoids, glycosides, saponins, and the important constituents such as bacosides, bacopasides, and bacopasaponins, which all of these contribute to its remedial properties. This article provides a brief overview of the memory boosting activity of brahmi, (B. monnieri), to further provide an up-to-date review showing its importance especially, memory boosting.

Keywords

Bacoside Bacopa monnieri Brahmi Memory boosting Neurological protective.

References

  1. Afjalus, S.M., Chakma, N., Rahman, M., Salahuddin, M. and Kumar, S.S. (2012). Assessment o analgesic, antidiarrhoeal and cytotoxic activity of ethanolic extract of the whole plant of Bacopa monnieri Linn. Int. Res. J. Pharm., 3: 98-101.
  2. Agrawal, H., Kaul, N., Paradkar, A.R. and Mahadik, K.R. (2006). Separation of bacoside A3 and bacopaside II, major triterpenoid saponins in Bacopa monnieri, by HPTLC and SFC. Application of SFC in implementation of uniform design for herbal drug standardization, with thermodynamic study. ACTA Chromatogr., 17: 125-150
  3. Aguiar, S. and Borowski, T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res., 16: 313–326. 
  4. Barbhaiya, H.C., Desai, R.P., Saxena, V., Pravina, K., Wasim, P., Geetharani, P., Allan, J.J., Venkateshwarlu, K. and Amit, A. (2008). Efficacy and tolerability of BacoMinds on memory improvement in elderly participants - a double blind placebo controlled study. J. Pharmacol. Toxicol., 3: 425–434.
  5. Bhowmik, D., Tiwari, C.P., Tripathi, K.K. and Sampath, K.P. (2010). Traditional Indian memory enhancer herbs and their medicinal importance. Ann. Biol. Res., 1: 41-46.
  6. Brettschneider, J., Tredici, K.D., Lee, V.M.Y. and Trojanowski, J.Q. (2015). Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat. Rev. Neurosci., 16: 109-120. 
  7. Chakravarty, K.A., Sakar, T., Masuda, K., Shiojima, K., Nakane, T. and Kawahara, N. (2001). Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monnieri. Phytochem., 58: 553-556. 
  8. Chakravarty, K.A., Garai, S., Maslda, K.N., Nakane, T. and Kawahara, N. (2003). Bacopasides III-V: Triterpenoid glycosides from Bacopa monnieri. Chem. Pharm. Bull., 51: 215-217.
  9. Channa, S., Dar, A., Anjum, S., Yaqoob, M. and Rahman, A. (2006). Anti-inflammatory activity of Bacopa monniera in rodents. J. Ethnopharmacol., 104: 286-289. 
  10. Chatterjee, M., Verma, P. and Palit, G. (2010). Comparative evaluation of Bacopa moniera and Panax quniquefolium in experimental anxiety and depressive models in mice, Indian J. Exp. Biol., 48: 306-313.
  11. Connolly, B.S. and Lang, A.E. (2014). Pharmacological treatment of Parkinson disease a review. J. Am. Med. Assoc., 311: 1670-1683. 
  12. Eckert, G.P. (2010). Traditional used plants against cognitive decline and Alzheimer disease. Front. Pharmacol., 1: 138-147. 
  13. Ghosh, T., Maity, T.K., Sengupta, P., Dash, D.K. and Bose, A. (2008). Antidiabetic and in vivo antioxidant activity of ethanolic extract of Bacopa monnieri Linn. Aerial parts: A possible mechanism of action. Iranian J. Pharm. Res., 7: 61-68.
  14. Ghosh, T., Maity, T.K. and Singh, J. (2011a). Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice. Oriental Pharm. Exp. Med., 11: 41-49.
  15. Ghosh, T., Maity, T.K. and Singh, J. (2011b). Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic rats. Planta Med., 77: 804-808. 
  16. Goswami, S., Saoji, A., Kumar, N., Thawani, V., Tiwari, M. and Thawani, M. (2011). Effect of Bacopa monnieri on cognitive functions in Alzheimer’s disease patients. Int. J. Collab. Res. Int. Med. Pub. Health, 3: 285-293.
  17. Gudipati, T., Srivastava, P., Bhadauria, R. and Prasad, G.B.K.S. (2012). Hepatoprotective potential of in vitro Bacopa monnieri L. against carbon tetrachloride – induced hepatotoxicity in albino mice. Int. J. Pharm. BioSci., 3: 664-672.
  18. Hazra, S., Banerjee, R., Das, B.K., Ghosh, A.K., Banerjee, T.K., Hazra, U.S., Biswas, S.K. and Mondal, A.C. (2012). Evaluation of antidepressant activity of Bacopa monnieri in rat: A study in animal model of depression. Drug Discov., 2: 8-13
  19. Hebert, L.E., Weuve, J., Scherr, P.A. and Evans, D.A. (2013). Alzheimer disease in the United States (2010-2050) estimated using the 2010 Census. Neurol., 80: 1778–83.
  20. Ho, S.C., Ho, Y.F., Lai, T.H., Liu, T.H. and Wu, R.Y. (2005). Traditional Chinese herbs against hypertension enhance memory acquisition. Am. J. Chinese Med., 33: 787-795.
  21. Hou, C.C., Lin, S.J., Cheng, J.T. and Hsu, F.L. (2002). Bacopaside III, bacopasaponin G and bacopasides A, B and C from Bacopa monnieri. J. Nat. Prod., 65: 1759-1763
  22. Integrated Taxonomic Information System (ITIS). Bacopa monnieri. Taxonomic Serial No.:33038. Geological Survey, VA, USA, 2015.
  23. Jadiya, P., Khan, A., Sammi, S.R., Kaur, S., Mir, S.S. and Nazir, A. (2011). Anti-parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s disease. Biochem. Biophy. Res. Com., 413: 605-610.
  24. Jatwa, V., Khirwadkar, P. and Dashora, K. (2014). Indian traditional memory enhancing herbs and their medicinal benefits. Indian J. Res. Pharm. Biotechnol., 2: 1030-1037.
  25. Joshi, B.B., Patel, M.G.H., Dabhi, B. and Mistry, K.N. (2013). In vitro phytochemical analysis and anti-microbial activity of crude extract of Bacopa monniera. Bull. Pharm. Med. Sci., 1: 128-131.
  26. Joshi, B.B., Patel, J., Chudasama, P. and Mistry, K.N. (2014). In vitro antioxidant, anti-inflammatory and anti-proliferative activity of crude extract of Bacopa monnieri. World J. Pharm. Pharm. Sci., 3: 646-662.
  27. Kamesh, V. and Sumathi, T. (2012). Antihypercholesterolemic effect of Bacopa monniera linn. on high cholesterol diet induced hypercholesterolemia in rats. Asian Pacific J. Trop. Med., 5: 949-955.
  28. Kamkaew, N., Scholfield, C.N., Inqkaninan, K., Maneesai, P., Parkington, H.C., Tare, M. and Chootip, K. (2011). Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types. J. Ethnopharmacol., 13: 790-795.
  29. Kamonwannasit, S., Phrompittayarat, W., Ingkaninan, K., Tanaka, H. and Putalun, W. (2008). Improvement of pseudojujubogenin glycosides production from regenerate Bacopa monnieri (L.) Wettst. and enhanced yield by elicitors. Zeitschrift für Naturforschung C – J. Biosci., 63c: 879-883.
  30. Kumar, H., Song, S.Y., More, S.V., Kang, S.M., Kim, B.W., Kim, I.S. and Choi, D.K. (2013). Traditional Korean East Asian medicines and herbal formulations for cognitive impairment. Molecules, 18: 14670-14693. 
  31. Kumar, A. and Ekavali, A.S. (2015). A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacol. Reports, 67: 195-203.
  32. Kunte, K.B. and Kuna, Y. (2013). Neuroprotective effect of Bacopa monniera on memory deficits and ATPase system in Alzheimer’s disease (AD) induced mice. J. Sci. Inn. Res., 2: 719-735.
  33. Mahato, S., Garai, S. and Chakravarty, A. (2000). Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monnieria. Phytochem., 53: 711-714.
  34. Mannan, M.A., Abir, A.B. and Rahman, M.R. (2015). Antidepressant-like effects of methanolic extract of Bacopa monniera in mice. BMC Complement. Altern. Med., 15: 337-343.
  35. Medina, Y.I. and Evans, A.C. (2015). On the central role of brain connectivity in neurodegenerative disease progression. Frontiers Aging Neurosci., 7: 90-99.
  36. Meena, H., Pandey, H.K., Pandey, P., Arya, M.C. and Ahmed, Z. (2012). Evaluation of antioxidant activity of two important memory enhancing medicinal plants Bacopa monnieri and Centella asiatica. Indian J. Pharmacol., 44: 114-117.
  37. Menken, M., Munsat, T.L. and Toole, J.F. (2000). The global burden of disease study: implications for neurology. Arch. Neurol., 57: 418-420.
  38. Mitra, P.K. (2014). Hypolipidemic effect of Bacopa monnieri (L.) Wettst leaves in rats: seasonal variation. Eur. J. Mol. Biol. Biochem., 1: 124-127.
  39. Mohan, N., Jassal, P.S., Kumar, V. and Singh, R.P. (2011). Comparative in vitro and in vivo study of antioxidants and phytochemical content in Bacopa monnieri. Recent Res. Sci. Technol., 3: 78-83.
  40. Nakamura, T., Komai, N., Isogami, I., Ueno, K., Ikegami, F., Ono, K. and Yano, S. (2006). Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice. J. Nat. Med., 60: 64-67. 
  41. Nandagaon, V. and Kulkaru, A.R. (2013). In vitro antioxidant and cytotoxicity activity of Bacopa monnieri and Baliospermum montanum muell Arg. Int. J. Pharm. App., 4: 63-67.
  42. Onsa-sard, A., Scholfield, C.N., Ingkaninan, K., Srimachai, S., Kamkaew, N. and Chootip, K. (2012). Oral Bacopa monnieri is antihypertensive in rats chronically treated with L-NAME. J. Physiol. Biomed. Sci., 25: 23-26.
  43. Othman, Z., Zakaria, R., Hussain, N.H.N., Hassan, A., Shafin, N., Rahbi, B.A. and Ahmad, A.H. (2015). Potential role of honey in learning and memory. Med. Sci., 3: 3-15.
  44. Pant, D., Singh, S.P., Pant, K. and Sati, S.C. (2015). Evaluation of free radical scavenging activity of hydroethanolic extract of Bacopa monnieri through DPPH Assay. Int. J. Pharm. Sci. Res., 6: 934-938.
  45. Patil, A., Vadera, K., Patil, D., Phatak, A., Juvekar, A. and Chandra, N. (2014). In vitro anticancer activity and phytochemical analysis of Bacopa monnieri (L.) wettst. Int. J. Pharm. Sci. Res., 5: 4432-4438.
  46. Peng, L., Zhou, Y., Kong, D.Y. and Zhang, W.D. (2010). Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother. Res., 24: 864-868.
  47. Peth-Nui, T., Wattanathorn, J., Muchimapura, S., Tong-Un, T., Piyavhatkul, N., Rangseekajee, P., Ingkaninan, K. and Vittaya-areekul, S. (2012). Effects of 12-Week Bacopa monnieri consumption on attention, cognitive processing, working memory, and functions of both cholinergic and monoaminergic systems in healthy elderly volunteers. Evid. Based Complem. Altern. Med., Article ID 606424.
  48. Philippine Medicinal Plants (PMP). Bacopa monnieri (Linn.) Wettst, (2014). 
  49. Phrompittayarat, W., Wittaya-areekul, S., Jetiyanon, K., Putalun, W., Tanaka, H. and Ingkaninan, K. (2007). Determination of saponin glycosides in Bacopa monnieri by reversed phase high performance liquid chromatography. Thai Pharm. Health Sci. J., 2: 26-32.
  50. Phrompittayarat, W., Wittaya-areekul, S., Jetiyanon, K., Putalun, W., Tanaka, H. and Ingkaninan, K. (2008). Stability studies of saponins in Bacopa monnieri dried ethanolic extracts. Planta Med., 74: 1756-1763.
  51. Prasenjit, M., Tanaya, G. and Kumar, M.P. (2014). Effect of an isolated compound (BM-1) from Bacopa monnieri (L.) Wettst. leaves on serum lipids in normal and diabetic Rats. SMU Med. J., 1: 166-174.
  52. Rajashekharappa, S., Krishna, V., Sathyanarayana, B.N. and Gowdar, H.B. (2008). Antibacterial activity of bacoside-A an active constituent isolated of Bacoma monnieri (L.) Wettest. Pharmacologyonline, 2:517-528.
  53. Ramana Murty Kadali, S.L.D.V., Das, M.C., Srinivasa Rao, A.S.R. and Karuna Sri, G. (2014). Antidepressant activity of Brahmi in albino mice. J. Clin. Diag. Res., 8: 35-37.
  54. Ramanan, V.K. and Saykin, A.J. (2013). Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer’s disease, Parkinson’s disease, and related disorders. Am. J. Neuro. Dis., 2: 145-175.
  55. Roodenrys, S., Booth, D., Bulzomi, S., Phipps, A., Micallef, C. and Smoker, J. (2002). Chronic effects of Brahmi (Bacopa monnieri) on human memory, Neuropsychopharmacol., 27: 279-281.
  56. Shahid, M. and Subhan, F. (2014). Protective effect of Bacopa monniera methanol extract against carbon tetrachloride induced hepatotoxicity and nephrotoxicity. Pharmacologyonline, 1Mahidol University International College, Mahidol University, Salaya Campus, Nakhon Pathom 73170, Thailand 2: 18-28.
  57. Shen, Y.H., Zhou, Y., Zhang, C., Liu, R.H., Su, J., Liu, X.H. and Zhang, W.D. (2009). Antidepressant effects of methanol extract and fractions of Bacopa monnieri. Pharm. Biol., 47: 340-343.
  58. Sindhu, P., Chowta, M.N., Nishith, R.S., Rai, S., Gadgade, A. and Rajeshwari, S. (2014). Evaluation of antidepressant activity of Bacopa monnieri in mice. Int. J. Pharm., 4: 144-148.
  59. Singh, H.K. and Dhawan, B.N. (1997). Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J. Pharmacol., 29: S359-S365.
  60. Singh, S.K. (2012). Phytochemical analysis of leaf callus of Bacopa monnieri L. Int. J. Sci. Res. Pub., 2: 1-3.
  61. Sivaramakrishna, C., Rao, C.V., Trimurtulu, G., Vanisree, M. and Subbaraju, G.V. (2005). Triterpenoid glycosides from Bacopa monnieri. Phytochem., 66: 2719-2728.
  62. Subashri, B. and Pillai, Y.J.K. (2014). A comparative study of antioxidant activity of Baccopa monnieri (L.) Pennell using various solvent extracts and its GC-MS analysis. Int. J. Pharm. Pharm. Sci., 6: 494-498.
  63. Subhan, F., Abbas, M., Rauf, K. and Baseer, A. (2010). Anti GIT motility, toxicological and phytochemical studies on Bacopa monnieri. Pharmacologyonline, 3: 937-950.
  64. Swathi, G., Visweswari, G. and Rajendra, W. (2013). Evaluation of rotenone induced Parkinson’s disease on glutamate metabolism and protective strategies of Bacopa monnieri. Int. J. Plant Ani. Environ. Sci., 3: 62-67.
  65. Tothiam, C., Phrompittayarat, W., Putalun, W., Tanaka, H., Sakamoto, S., Khan, I.A. and Ingkaninan, K. (2011). An enzyme-    linked immunosorbent assay using monoclonal antibody against Bacoside A3 for determination of jujubogenin glycosides in Bacopa monnieri (L.) Wettst. Phytochem. Anal., 22: 385-391. 
  66. Tripathi, N., Chouhan, D.S., Saini, N. and Tiwari, S. (2012). Assessment of genetic variations among highly endangered medicinal plant Bacopa monnieri (L.) from central India using RAPD and ISSR analysis. 3 Biotech, 2: 327-336.
  67. Trivedi Manisha, N., Khemani, A., Vachhni Urmila, D., Shah Charmi, P. and Santani, D.D. (2011). Comparative pharmacognostic and phytochemical investigation of two plant species valued as Medhya Rasayanas. Int. J. Appl. Biol. Pharm. Technol., 2: 28-36.
  68. Uabundit, N., Wattanathorn, J., Mucimapura, S. and Ingkaninan, K. (2010). Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J. Ethnopharmacol., 127: 26–31.
  69. Udgire, M. and Pathade, G.R. (2012). Preliminary phytochemical and antifungal screening of crude extracts of the Bacopa monnieri. Uni. J. Environ. Res. Technol., 2: 347-354.
  70. Venkatesan, R., Ji, E. and Kim, S.Y. (2015). Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review. BioMed Res. Int., Article ID 814068; 22 pages. 
  71. Zhou, Y., Shen, Y.H., Zhang, C., Su, J., Liu, R.H. and Zhang, W.D. (2007). Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. J. Nat. Prod., 70: 652-655. 
     

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