Chief EditorT. Mohapatra
Print ISSN 0367-8245
Online ISSN 0976-058X
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Antithrombotic activity of turmeric (Curcuma longa): A review
First Online 23-04-2016|
The venous and arterial thromboembolic disorders are still be the major cause of morbidity and mortality worldwide. Now a days, the concept of “healthy diets” is very popular in the present lifestyle. So, the use of antithrombotic agents is of considerable interest in the role of natural food products and their bioactive components in the prevention and treatment of these disorders. Moreover, epidemiologic studies have provided evidence that foods with the thrombolytic/fibrinolytic effect could reduce the risk of thrombosis. “Blood thinner foods” have the antiplatelet, anticoagulant, and/or fibrinolytic properties. Natural foods that contain salicylates can mimic some of the antiplatelet effects of cardiovascular drug like aspirin. Fruits (i.e., grapefruit, guava, kiwi, pineapple, and watermelon), vegetables (i.e., alfalfa, beans, corn, potato, radish, and zucchini), and spices (i.e., chili, curry, ginger, rosemary and turmeric) are reported that they are containing salicylates compounds. Turmeric (Curcuma longa) is a small rhizomatous perennial herb belonging to Zingiberaceae family originating from Southeastern Asia. It is a folk remedy for applying on fresh cuts to stop bleeding and for the healing of wound. Further, turmeric has been shown to possess anticancer, antidiabetic, antifertility, anti-inflammatory, antimicrobial and antioxidant properties. Its phytochemical substances are alkaloids, curcuminoids, flavonoids, glycosides, saponins, which all of these contribute to its remedial properties. This article provides a brief overview of the antithrombotic activity of turmeric, C. longa to further provide an up-to-date review showing its importance.
- Adaramoye, O.A., Odunewu, A.O. and Farombi, E.O. (2010). Hepatoprotective effect of Curcuma longa L. in D- galactosamine induced liver injury in mice: Evidence of antioxidant activity. Afr. J. Med. Med. Sci. 39: S27-S34.
- Adepoju, G.K.A. and Adeyemi, T. (2010). Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin. J. Young Pharm. 2: 269-272.
- Ahmad, A., Khan, A. and Safdar, M. (2011). Curcumin: a natural product of pharmaceutical importance. Int. J. Pharm. Clin. Exp. Bio. 5: 44-49.
- Ali, R., Hossain, M.S., Islam, A., Arman, S.I., Raju, G.S., Dasgupta, P. and Noshin, T.F. (2014). Aspect of thrombolytic therapy: A review. Sci. World J. Article ID 586510, 8 pages
- Apu, A.S., Chowdhury, F.A., Khatun, F., Jamaluddin, A.T.M. and Arindom Pal, A.H.P. (2013). Phytochemical screening and in vitro evaluation of pharmacological activities of Aphanamixis polystachya (Wall) Parker fruit extracts. Trop. J. Pharm. Res. 12: 111-116.
- Basnet, P. and Skalko-Basnet, N. (2012). Curcumin: A challenge in cancer treatment. J. Nepal Pharm. Assoc. 26: 19-47.
- Baxla, S.L., Gora, R.H., Kerketta, P., Kumar, N., Roy, B.K. and Patra, P.H. (2013). Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats. Vet. World 6: 664-667.
- Chakraborty, P.S., Ali, S.A., Kaushik, S., Ray, R.K., Yadav, R.P., Rai, M.K. and et al. (2011). Curcuma longa – A multicentric clinical verification study. Indian J. Res. Homoeopathy 5: 19-27.
- Choudhary, N. and Sekhon, B.S. (2012). Potential therapeutic effect of curcumin – an update. J. Pharm. Edu. Res. 3: 64-71.
- Daley, M.J., Murthy, M.S. and Peterson, E.J. (2015). Bleeding risk with systemic thrombolytic therapy for pulmonary embolism: Scope of the problem. Ther. Adv. Drug Saf. 6: 57-66.
- Dayaganon, A.J.B., Sarpong, S.M.L., Sapilan, J.B. and Fernandez, A.M. (2013). Anticoagulant activity of Horseradish Moringa oleifera and Oregano Coleus aromaticus leaf extracts and Kamias Averrhoa bilimbi fruit juice on human blood samples. Off. J. Med. Lab. Sci. Nursing Res. 1(1).
- Deb, N., Majumdar, P. and Ghosh, A.K. (2013). Pharmacognostic and phytochemical evaluation of the rhizomes of Curcuma longa Linn. J. Pharm. Sci. Tech. 2: 81-86.
- Durairaj, B. and Dorai, A. (2010). Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers. Braz. J. Pharm. Sci. 46: 579-583.
- European Food safety Authority. (2010). Scientific opinion on the re-evaluation of curcumin (E100) as a food additive. EFSA J. 8: 1679, 46pp.
- Goel, A., Kunnumakkara, A.B. and Aggarwal, B.B. (2008). Curcumin as ‘‘Curecumin’’: From kitchen to clinic. Biochem. Pharmacol. 75: 787–809.
- Gupta, A., Mahajan, S. and Sharma, R. (2015). Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus. Biotechnol. Reports 6: 51-55.
- Halabi, S., Battah, A.A., Aburjai, T. and Hudaib, M. (2005). Phytochemical and antiplatelet investigation of Gundelia tournifortii. Pharm. Biol. 43: 496-500.
- Han, J.M., Lee, J.S., Kim, H.G., Seol, I.C., Im, H.J., Cho, J.H. and Son, C.G. (2015). Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model. J. Ethnopharmacol. 173: 217-224.
- Heger, M., van Golen, R.F, Broekgaarden, M. and Michel, M.C. (2014). The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. Pharmacol. Rev. 66: 222–307.
- Imran, I., Hussain, L., Ahmed, S., Rasool, N., Rasool, S., Abbas, G. and Ali, M.Y. (2012). Antiplatelet activity of methanolic extract of Acacia leucophloea bark. J. Med. Plants Res. 6: 4185-4188.
- Issuriya, A., Kumarnsit, E., Wattanapiromsakul, C. and Vongvatcharanon, U. (2014). Histological studies of neuroprotective effects of Curcuma longa Linn. on neuronal loss induced by dexamethasone treatment in the rat hippocampus. Acta Histochem. 116: 1443-1453.
- Jawad Jafar, S.M. (2008). In vitro thrombolytic/fibrinolytic effects of rue aqueous distilled extract. J. Al-Nahrain Uni. 11: 28-33.
- Jin, W.Y., Kim, S.H., Kim, H.K., Jang, D.G., Nam, J.B., Kang, Y.M., Hwang, B.Y. and Kim, D.S. (2013). Antiplatelet and antithrombotic effect of Phyllostachys pubescens leaves and Mume Fructus combination. Int. Med. Res. 2: 70-75.
- Joshi, J., Ghaisas, S., Vaidya, A., Vaidya, R., Kamat, D.V., Bhagwat, A.N. and Bhide, S. (2003). Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J. Assoc. Physicians. India. 51: 1055-1060.
- Kamble, S.I. and Dahake Pavan, R. (2015). Report on antimicrobial activity and phytochemical screening of Curcuma longa Linn. Int. Ref. Multidis. J. Contemp. Res. 3: 90-96.
- Kim, Y.J., You, Y.H. and Jun, W.J. (2012). Hepatoprotective activity of fermented Curcuma longa L. on galactosamine- intoxicated rats. Korean Soc. Food Sci. Nut. 41: 790-795.
- Kim, M.S., Oh, I.T., Jun, D.Y., Lee, J.Y., Lee, J.Y., Sohn, H.Y. and et al. (2013). Anticoagulant and fibrinolytic activities of Hwanggeumchal Sorghum in vitro. J. Life Sci. 23: 1460-1470.
- Kim, Y., You, Y., Yoon, H.G., Lee, Y.H., Kim, K., Lee, J. and et al. (2014). Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chem. 151: 148-153.
- Lal, J. (2012). Turmeric, curcumin and our life: a review. Bull. Env. Pharmacol. Life Sci. 1: 11-17.
- Lee, H.S. (2006). Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Biores. Technol. 97: 1372-1376.
- Li, J.M., Li, Y.C., Kong, L.D. and Hu, Q.H. (2010). Curcumin inhibits hepatic protein tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatol. 51: 1555–1566.
- Li, S., Yuan, W., Deng, G., Wang, P., Yang, P. and Aggarwal, B.B. (2011). Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharm. Crops 2: 28-54.
- Manikandan, P., Sumitra, M., Aishwarya, S., Manohar, B., Lokanadam, B. and Puvanakrishnan, R. (2004). Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int. J. Biochem. Cell Biol. 36: 1967–1980.
- Mayanglambam, A., Dangelmaier, C.A., Thomas, D., Reddy, C.D., Daniel, J.L. and Kunapuli, S.P. (2010). Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCã2. Platelets 21: 211-220.
- Melo-Silveira, B.F., Fidelis, G.P., Pereira Costa, M.S.S., Silva Telles, C.B., Dantas Sanos, N., de Oliveira Elias, S. and et al. (2012). In vitro antioxidant, anticoagulant and antimicrobial activity and in inhibition of cancer cell proliferation by xylan extracted from corn cobs. Int. J. Mol. Sci 13: 409-426.
- Panahi, Y., Rahimnia, A., Sharafi, M., Alishiri, G., Saburi, A. and Sahebkar, A. (2014). Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother. Res. 28: 1625-1631.
- Panahi, Y., Hosseini, M.S., Khalili, N., Naimi, E., Majeed, M. and Sahebkar, A. (2015). Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin. Nut. Jan 7. pii: S0261-5614(15)00002-3.
- Pawlaczyk, I., Czerchawski, L., Kuliczkowski, W., Karolko, B., Pilecki, W., Witkiewicz, W. and Gancarz, R. (2011). Anticoagulant and anti-platelet activity of polyphenolic-polysaccharide preparation isolated from the medicinal plant Erigeron Canadensis L. Throm. Res. 127: 328-340.
- Pawlaczyk, I., Tsirigotis., M.L., Capek, P., Matulová, M., Sasinková, V., D¹browski, P., Witkiewicz, W. and Gancarz, R. (2013). Effects of extraction condition on structural features and anticoagulant activity of F. vesca L. conjugates. Carbohydr. Polym. 92: 741-750.
- Prakash, P., Misra, A., Surin, W.R., Jain, M., Bhatta, R.S., Pal, R., Raj, K., Barthwal, M.K. and Dikshit, M. (2011). Anti- platelet effects of curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Throm. Res. 127: 111-118.
- Prandoni, P. (2009). Venous and arterial thrombosis: Two aspects of the same disease? Clin. Epidemiol. 1: 1-6.
- Ramjan, A., Hossain, M., Runa, J.F., Hasanuzzaman, M. and Mahmodul, I. (2014). Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds. Avicenna J. Phytomed. 4: 430-436.
- Sahebkar, A. (2014). Curcuminoids for the management of hypertriglyceridaemia. Nat. Rev. Cardiol. 11: 123.
- Sahebkar, A. (2015). Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant mechanisms. Nat. Prod. Res. 29: 491-492.
- Salama, S.M., Abdulla, M.A., AlRashdi, A.S., Ismail, S., Alkiyumi, S.S. and Golbabapour, S. (2013). Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Comp. Alt. Med. 13: 56.
- Sengupta, M., Sharma, G.D. and Chakraborty, B. (2011). Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pac. J. Trop. Biomed. 1: 193-199.
- Shanmugam, M.K., Rane, G., Kanchi, M.M., Arfuso, F., Chinnathambi, A., Zayed, M.E. and et al. (2015). The multifaceted role of curcumin in cancer prevention and treatment. Molecules 20: 2728-2769.
- Shin, H.S., Han, J.M., Kim, H.G., Choi, M.K., Son, C.G., Yoo, H.R., Jo, H.K. and Seol, I.C. (2014). Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice. J. Ethnopharmacol. 153: 142–150.
- Shivalingu, B.R., Vivek, H.K., Nafeesa, Z., Priya, B.S. and Nanjunda Swamy, S. (2015). Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species. J. Ethnopharmacol. 172: 261-264.
- Srinivasa Reddy, C., Ammani, K. and Rose Mary, T. (2015). In vitro evaluation of fibrinolytic and antioxidant activities of Maba buxifolia (Rottb.) Juss. Stem. J. Pharma. Phytochem. 3: 148-151.
- Srivastava, K.C., Bordia, A. and Verma, S.K. (1995). Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alter eicosanoid metabolism in human blood platelets. Prostaglandins Leukot. Essent. Fatty Acids 52: 223-227.
- Sugerman, D.T. (2013). Blood thinners. J. Am. Med. Assoc. 10: 2579-2580.
- Taylor, R.A. and Leonard, M.C. (2011). Curcumin for inflammatory bowel disease: A review of human studies. Altern. Med. Rev. 16: 152-156.
- Thong-Ngam, D., Choochuai, S., Patumraj, S., Chayanupatkul, M. and Klaikeaw, N. (2012). Curcumin prevents indomethacin-induced gastropathy in rats. World J. Gastroenterol. 18: 1479-1484.
- Trinidad, T.P., Sagum, R.S., Leon, M.P., Mallillin, A.C. and Borlagdan, M.P. (2012). Zingiber officinale and Curcuma longa as potential functional foods/ingredients. Food Pub. Health 2: 1-4.
- Unnikrishnan, V. and Nishteswar, K. (2015). Antiplatelet Ayurvedic herbs in the management of cardiovascular disease- a review. Int. Ayurvedic Med. J. 3: 1462-1473.
- Urrutia, C.T., Guzman, L., Hirschmann, G.S., Carrasco, R.M., Alarcon, M., Astudillo, L. and et al. (2011). Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Blood Coagul. Fibrinolysis 22: 197-205.
- Varalakshmi, D. and Abhinov, T. (2015). Protective effect of aqueous extract of Curcuma longa on ethanol induced Hepatotoxicity in Rat. Indian J. Res. Pharm. Biotechnol. 3: 81-84.
- Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T. and et al. (2012). Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. Am. J. Cardiol. 110: 40-44.
- Wuthi-udomlert, M., Grisanapan, W., Luanratana, O. and Caichompoo, W. (2003). Antifungal activity of Curcuma longa grown in Thailand. Southeast Asian J. Trop. Med. Pub. Health 31: 178-182.
- Yadav, D., Yadav, S.K., Khar, R.K., Mujeeb, M. and Akhtar, M. (2013). Turmeric (Curcuma longa L.): A promising spice for phytochemical and pharmacological activities. Int. J. Green Pharm. 7: 85-89.
- Zong, H., Wang, F., Fan, Q.X. and Wang, L.X. (2012). Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Mol. Biol. Rep. 39: 4803-4808.
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