Background: Xenical drug impact was used for studying losing weight by testing some physiological parameters in male rats compared to (Hatra herbs&reg;) plants extract used for slimming. 
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Methods: ALT,AST,ALP,B.UREA Creatinine, lipids profile, TSH, T4 and T3 were examined. male rats separated into 3 groups: control group, a Xenical group (120 mg\kg b.wt) and a mix plants extract group (200 mg\kg b.wt). 
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Result: Results showed that body weight, cholesterol, triglyceride, VLDLand&nbsp; LDL had a significant drop in plants extract group compared to control, whilst ALTandAST showed a substantial rise in Xenical group compared to control also a significant surge in ALP&nbsp; in both treated groups compared to control . on other hand had, T3 and TSH had a significant reduced in Xenical group, while T3&nbsp; showed non significant differences in plants extract group compared to control ,in the meantime T4 exhibited increased significance in Xenical group and non significant differences&nbsp; in plants extract group compared to control. B.urea showed a significant escalation in Xenical group compared to plants extract group and control, while creatinine noted no significant differences in all treated groups compared to control group. 
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The Harmful Effect of a Slimming Drug Compared to a Mix of Some Plants Extract on Rats