Background: A total of 24 dogs confirmed with acute kidney disease were randomly divided into four treatment groups each comprising 6 dogs. Additionally, six healthy dogs were selected as the healthy control group. 
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Method: A total of 24 dogs confirmed for acute kidney disease were divided randomly into four treatment groups i.e., G2, G3, G4, and&nbsp;G5&nbsp;each comprising of 6 dogs. Six healthy dogs were selected as the healthy control group (G1). Dogs of group G2 were treated with Enalapril, G3&nbsp;were treated with Pulv. Boerhaavia diffusa, G4 were treated with Pulv. Tribulus terrestris and G5&nbsp;with the combination of Pulv. Boerhaavia diffusa and Pulv. Tribulus terrestris. Supportive treatment was given as per the requirement in all the treatment groups. 
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Result: Haematological parameters showed a significant decrease in Hb, TEC and PCV on day 0 (pre-treatment) in all dogs. Biochemical parameters revealed a&nbsp;significant increase in the values of serum creatinine, BUN, ALP, and AST levels while serum sodium concentration decreased. Proteinuria was observed on urinalysis. However, on day 30 (post-treatment) significant improvement was observed in the values of haemato-biochemical and urinary parameters.

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Therapeutic Efficacy of Boerhaavia diffusa and Tribulus terrestris on Acute Kidney Disease in Dogs

<div>Background: Diseases involving urinary system are very common in dogs causing significant morbidity and mortality in dogs. Renal failure and urinary obstruction are frequently encountered in clinical cases. Early diagnosis and treatment increase the survival rate and decreases the chances of complications related to renal failure. The present study was conducted to evaluate haemato-biochemical alterations in dogs having urinary system dysfunction. 
 
Methods: The study was conducted on 38 dogs to observe the haemato-biochemical parameter changes in dogs suffering from obstructive and non-obstructive renal system affections as compared to healthy dogs. Various haemato-biochemical parameters viz. Hb, PCV, TEC, TLC, DLC, BUN, creatinine, ALT, AST, ALP, TP, albumin and A:G ratio were evaluated. Qualitative analysis of urine was done using Multistix dip stick method. 
 
Result: In the present study the values of various haemato-biochemical parameters showed different pattern in both obstructive and non-obstructive renal diseases. Significant haematobiochemical changes reported in renal failure dogs were anemia, azotemia, increased alkaline phosphatase and AST values and decreased A:G ratio and in dogs with urinary obstruction the significant changes were uremia and leukocytosis. The results of the study suggested that the evaluation of various haemato-biochemical parameters help in diagnosis and predicting the prognosis of a renal disease.</div>

Therapeutic Efficacy of Boerhaavia diffusa and Tribulus terrestris on Acute Kidney Disease in Dogs

Haemato-biochemical Alterations in Obstructive and Non-obstructive Renal Diseases