<div style="text-align: justify;">Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 &igrave;g/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 &igrave;g/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.&nbsp;</div>

<div style="text-align: justify;">Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats</div>

<div><strong>Background:</strong> In the ophthalmological examination of a 1.5-year-old male dwarf Campbell hamster, who was examined with complaints of photophobia, pain, weakness and whitening of the eye color, hypermature cataract and chronic uveitis were observed in the left eye.<br />
<br />
<strong>Methods:</strong> Local antibiotic therapy was administered to the patient for the first ten days in order to eliminate a possible microbial agent. In addition, local NSAI drugs were applied to reduce pain and inflammation. Then, peros Prednol (methylprednisolone) was administered at a dose of 0.5 mg/kg for the first ten days and 1 mg/kg for the next ten days in order to suppress the inflammation associated with uveitis. The patient&rsquo;s body weight and intraocular pressure were measured before the treatment. During the treatment, intraocular pressure values were checked every day. During this period, the patient was fed ad libitum at normal room temperature, in his own cage.<br />
<br />
<strong>Result: </strong>As a result of the treatment applied to the patient, who was followed up for more than a month, symptoms such as pain, photophobia and blepharospasm disappeared and the patient&rsquo;s eating and drinking status improved compared to the past. However, increasing dose of Prednol did not have the expected effect on intraocular pressure values. Due to the very small size of the hamster eye in the treatment of hypermature cataracts, lens removal cannot be performed as easily as in other species.</div>


Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats

Unilateral Hypermature Cataract and Uveitis in Dwarf Campbell’s Hamster (Phodopus campbelli)