<div style="text-align:justify">A clinical research was undertaken to evaluate the effect of low dose metronomic (LDM) chemotherapy in 18 clinical cases of canine mammary neoplasms (CMN). The cases were randomly divided into three groups each consisting of six animals. Group I was subjected to LDM therapy with cyclophosphamide @ 10 mg/m2 and piroxicam @ 0.3 mg/kg per os for a period of eight weeks pre operatively on alternate days. Group II was subjected to mere surgical excision alone. Group III was subjected to LDM therapy from 10th day following tumour excision for a period of eight weeks as in group I. Effect of LDM therapy was evaluated based on regression of tumour size and the disease free interval. The haematological and biochemical values were evaluated. Among the three groups, Group I showed progressive regression in the disease free interval improving the quality of life.</div>

<div style="text-align: justify;">Low dose metronomic chemotherapy with cyclophosphamide and piroxicam for the management of canine mammary neoplasms</div>

<p><strong>Background: </strong>Piroxicam (PX) is an NSAID linked to hepato-renal toxicity. This study evaluated quercetin&rsquo;s (QUE) protective role against PX-induced damage in pregnant rats.<br />
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<strong>Methods: </strong>Pregnant rats (n=40) were divided into four groups (13 days): Control, QUE (75 mg/kg), PX (7 mg/kg <em>i.p.</em>) and QUE+PX. Hepato-renal toxicity was assessed <em>via </em>hematological, biochemical, histopathological, immunohistochemical (caspase-3, TNF-&alpha;, IL-6), oxidative stress markers and DNA fragmentation.<br />
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<strong>Result: </strong>PX caused hematological disturbances, elevated liver enzymes (ALT, AST) and kidney markers (creatinine, urea), decreased albumin and tissue damage. Increased MDA and decreased GSH/SOD indicated oxidative stress. Elevated caspase-3, TNF-&alpha; and DNA fragmentation confirmed apoptosis. QUE supplementation significantly reversed these alterations. Quercetin effectively ameliorated PX-induced hepato-renal toxicity through its antioxidant and anti-apoptotic properties.</p>


Low dose metronomic chemotherapy with cyclophosphamide and piroxicam for the management of canine mammary neoplasms

Role of Quercetin against the Effect of Piroxicam on the Liver and Kidney in Pregnant Rats