Background: Women are exposed to Paraphenylenediamine (PPD) during hair dyeing in a variety of Arab nations, PPD may damage internal organs and result in death. The current study intends to assess the histological and physiological studies on female albino rats treated with Paraphenylenediamine. 
 
Methods: 24 females rats were used in the study and divided into four groups each with 6 rats: group1: control female group, rats will be treated, orally with distilled water for 8 weeks, group 2 treated female group, rats will receive 10 mg/kg B.W of PPD in 1 ml distilled water once daily for 8 weeks by oral gavage, group 3: withdrawal control female group, rats receive distilled water for 8 weeks and left untreated for two weeks after stopping treatment, group 4: withdrawal treated female group, rats will receive 10 mg/kg B.W of PPD for 8weeks and left untreated for two weeks after stopping treatment. 
 
Result: It was observed on microscopic examination that orally applied PPD solution affects histology of rat ovary marker reduction in ovarian follicle numbers and degeneration of interstitial cells and some follicles, with observable modifications in physiological processes in hormones, In the treated female group, the serum levels of progesterone, estrogen and FSH hormones significantly increased when compared with the control female group. It was concluded from the results that orally applied PPD solution induces histomorphology and physiological changes in the ovary of rats with 10 mg/kg dose. 
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Histological and Physiological Studies on Adult Female Albino Rats Treated with Paraphenylenediamine