<div>Background: Respiratory diseases are very common in goats and cause severe economic loss to the rural poor farmers. Proper identification of the actual pathogen(s) responsible for the respiratory infections is critical for timely and proper management of those diseases. The present communication describes the spontaneous occurrence of concurrent Peste des petits ruminants (PPR) and contagious caprine pleuro-pneumonia (CCPP) in a goat flock. 
 
Methods: An outbreak of respiratory disease in a goat flock consisting of 45 Tellicherry cross bred animals in varying age groups was investigated during the month of February 2019 in Namakkal district of Tamil Nadu. Information of disease outbreak and flock details were collected. Samples from live (nasal, ocular and rectal swabs) and dead (lung, spleen and mesenteric lymph nodes) were collected for detection of Peste des petits ruminants virus (PPRV) and Mycoplasma capricolum subsp.capripneumoniae (MCCP) antigen by polymerase chain reaction. Tissues from heart, lung, liver, kidney, intestine, spleen and lymph node were collected in 10% neutral buffered formalin for histopathological examination. 
 
Result: Out of 45 goats at risk, 23 showed clinical signs and 17 died of disease conditions with morbidity, mortality and case fatality rate of 51.11%, 37.77% and 73.91% respectively. PPR was confirmed by RT-PCR with M gene specific primers (191bp) and CCPP was confirmed by PCR with 16S rRNA gene fragment (316 bp). Affected animals showed clinical signs of pyrexia, anorexia, marked depression, mild erosions in the oral mucosa, nasal and ocular discharge, coughing and diarrhoea. Necropsy examination revealed congested oral mucosa, extensive pleuritis with large fibrin clots on lung surface and greyish pink consolidation of cranial lobes and anterior parts of diaphragmatic lobes. On section, consolidated areas were granular in appearance. Histopathology of lung revealed thickening of pleura, interlobular septa and alveolar wall by fibrin deposition and infiltration of inflammatory cells. &nbsp;Pulmonary congestion, infiltration of neutrophils and mononuclear cells, syncytial cell formation with eosinophilic intracytoplasmic and intranuclear inclusions were also noticed. Visceral organs showed degenerative and necrotic changes.</div>

<div>Pathomorphology of Concurrent Peste des Petits Ruminants (PPR) and Contagious Caprine Pleuropneumonia (CCPP) in a Cross Breed Goat Flock</div>

<div>Mycoplasma infection of the respiratory tract of goats is prevalent worldwide including the South Asian sub-continent. Owing to intensive and large scale goat farming, the incidence of the disease is on an increase. Among various species of mycoplasma, Mycoplasma capricolum subspecies Capri pneumoniae is increasingly incriminated in Contagious Caprine Pleurapneumonia (CCPP) in goat populations with considerable economic fallout in the form of high morbidity and mortality. The disease manifestations in caprines are recorded as anorexia, high febrile reaction and respiratory embarrassment in the shape of clinical dyspnoea, polypnea, paroxysmal cough and sero-purulent nasal discharges. The disease is thus contracted by the healthy animals through aerosol, contaminated feed and water sources in the herd premises, without a protective immunity and that the conferred immunity in recovered cases being short-lived. The true lesions of CCPP are confined to the lung alveolar tissues of infected goats, which distinguish it from other respiratory diseases of small ruminants caused by the members of the Mycoplasma mycoides cluster.&nbsp;Atypical pneumonia caused by the mycoplasma infection of goats, also known as Contagious Caprine Pleuropneumonia (CCPP) has been more often reported from Africa and Asia than Europe. Classical, acute CCPP attributed to Mycoplasma capricolum subsp. Capri pneumoniae, originally known asthe F38 biotype (World Organisation for Animal Health, 2008) causes heavy kid mortality. Two other organisms in this group, M. mycoides subsp.&nbsp;capri and&nbsp;M. mycoides subsp.&nbsp;mycoides large-colony type, can cause disease in small ruminants that clinico-pathologically mimics CCPP&nbsp;but may have extra pulmonary signs and lesions, sometimes. Mycoplasma Capri pneumoniae and other members of the M. mycoides cluster cross-react in serological tests and share biochemical and genetic similarities. The most favourable epidemiological scenario in the Sub-continent is the hot humid climate during monsoons. The diversity and multi-etiological subspecies involved in the disease is detrimental in the development of an effective vaccine even though in some places a liquid vaccine is presently in use. At other places, anti-mycoplasmal antibiotics of aminoglycoside and fluoroquinolone and perhaps the macrolide groups remain to be the main option in preventing flock mortalities.</div>

​Caprine Respiratory Mycoplasmosis (Contagious Caprine Pleuropneumonia CCPP)- A Global Perspective of the Disease, Epidemiology, Diagnosis, Chemotherapy and Immunization: A Review

Pathomorphology of Concurrent Peste des Petits Ruminants (PPR) and Contagious Caprine Pleuropneumonia (CCPP) in a Cross Breed Goat Flock

​Caprine Respiratory Mycoplasmosis (Contagious Caprine Pleuropneumonia CCPP)- A Global Perspective of the Disease, Epidemiology, Diagnosis, Chemotherapy and Immunization: A Review

Caprine Respiratory Mycoplasmosis (Contagious Caprine Pleuropneumonia CCPP)- A Global Perspective of the Disease, Epidemiology, Diagnosis, Chemotherapy and Immunization: A Review