<div>Plant VOCs are signaling compounds that attract pollinators, protect plants from stress, disease and predation, have allelopathic effects and play a role in plant growth and development. The purpose of this review was to evaluate pollinator plants for secondary metabolite VOCs such as monoterpenes and sesquiterpenes for their potential medicinal value to pollinating insects. To address disease pathogens impacting native pollinators and honeybees, plants with medicinal VOCs can be selected for prairie strips and pollinator gardens as agricultural best management practices. Eight flowering plants - bee balm, echinacea, catmint, prairie rose, lavender, thyme, oregano and red clover contain VOCs in their nectars and pollens such as caryophyllene, myrcene, germacrene, cymene, thymol, cineol, carvacrol, borneol, nonanal, linalool and terpineol that offer antimicrobial, antifungal, anti-inflammatory, antioxidant benefits and some are acaricides that may aid in controlling the Varroa destructor mite (=jacobsoni).&nbsp;</div>

<div>Medicinal VOCs in Plants Recommended for Prairie Strips and Pollinator Gardens as Prophylactic and Curative Support for Pollinating Insects: A Review</div>

Background: Lavandula dentata is recognized for its therapeutic properties and has been traditionally used in various medicinal applications. Monoamine oxidases (MAOs) are critical for neurotransmitters breaking down; therefore, their inhibitors treat neurodegenerative disorders such as Alzheimer, Parkinson and amyotrophic lateral sclerosis diseases.&nbsp; 
 
Methods: The current study was done to analyze the bioactive compounds present in the methanolic extract of Lavandula dentata of Taif region, Saudi Arabia using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. In addition, computational analysis using SwissADME and ProTox-II was used to predict the physicochemical and biological activities and predicted toxicity of four selected components from lavender extract. Moreover, linalool and 7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid were selected for the molecular docking of Monoamine Oxidase A.&nbsp; 
 
Result: GC-MS analysis revealed a diverse array of bioactive compounds, including but not limited to linalool, retinal, chromene-2-one and 7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid, which are known for their pharmacological activities such as antimicrobial, anti-inflammatory and anxiolytic effects. In silico analysis has assumed that linalool is safe with a predicted toxicity LD50 2200 mg/kg (Class: 5). The docking affinity score of linalool to Monoamine Oxidase A is -24.4 and appears more stable in the docking site box due to the presence of nine hydrophobic interactions. Collectively this study contributes to the understanding of the chemical profile of Lavandula dentata and highlights its suitability for pharmaceutical and therapeutic applications along with exploring the specific bioactivities and potential synergistic effects of these compounds. In particular, linalool emerges as a promising bioactive compound in neurodegenerative disorders therapy through Monoamine oxidase A inhibition.

Medicinal VOCs in Plants Recommended for Prairie Strips and Pollinator Gardens as Prophylactic and Curative Support for Pollinating Insects: A Review

GC-MS Analysis and Molecular Docking Studies of Lavandula dentata Leaves Extract of Taif Region, Saudi Arabia