Background: This study aims to investigate the anti-obesity effect of GOE with adipokine (apelin and adiponectin) response at different doses (100 and 200 mg/kg) of GOE in normal healthy and obese rats with High-fat diet (HF). 
 
Methods: In this study, 36 adult male Wistar albino rats, aged between 8-10 weeks, were used. 6 groups were created, with 6 rats in each group: Control (C), Rat group without GOE and HF application, G100 (GOE 100 mg/kg group given with oral gavage route of administration (OGRA), G200 (GOE 200 mg/kg group given with OGRA), HFC&nbsp;(HF control group): no HF and no GOE group), HF100 (rats receiving HF were100 mg/kg graviola oil extract added to their diet), HF200 (rats receiving HF were 200 mg/kg graviola oil extract added to their diet). Blood samples were taken from the tail vein (vena caudalis) of all on days 0 and 60 of the study. Apelin and adiponectin levels in the serum samples were measured by ELISA method. 
 
Result:&nbsp; In the present study, a significant increase (p&lt;0.01) was observed in the mean serum apelin level in the HF groups at the end of the 60 day after HF induction, while a significant decrease (p&lt;0.01) was also detected in the adiponectin level. On the other hand, when examined in terms of BW, the most significant decrease due to GOE addition in the HF groups, i.e. the anti-obesity effect, was determined in the HFG200 mg/kg group (p&lt;0.01). As a result, it was concluded that GOE may be safe and beneficial when administered at a dose of 200 mg/kg in obesity-induced rats.

Effect of Graviola Oil Extract on Anti-obesity Effect and Adipokine (Apelin and Adiponectin) Response in High Fat Diet-induced Obese Rats