Background: Osteoporosis is a prevalent health concern among postmenopausal women. This randomized controlled trial (RCT) evaluated the effect of Godhum Satva versus calcium supplements in preventing osteoporosis. Given the increasing prevalence of osteoporosis among women, the primary aim of this randomized controlled trial was to evaluate the effect of Godhum Satva compared to calcium supplements in mitigating the onset of osteoporosis. Additionally, the research aimed to highlight the therapeutic potential of Nityasevaniya-Ahardravyas as a natural remedy for effectively managing the condition.&nbsp; 
 
Methods: In this open-label, two-arm, parallel-group RCT, 86 women aged 40-60 years with BMD between 1-2.5 SD below the mean were randomized by manual lottery method using opaque sealed envelopes. Participants received either Godhum Satva or calcium supplements, along withdietary and lifestyle modifications, for 60 days. The primary outcome was change in BMD at days. Secondary outcomes were changes in Asthikshaya Lakshana scores. Data were analyzed using paired/unpaired t-tests and Wilcoxon/Mann-Whitney tests using Statistical Package for Social Sciences (SPSS Version 20.0). 
 
Result: Both groups showed significant BMD improvements. Group B (Godhum Satva) had greater mean BMD change (-0.51; 95% CI: -0.63 to -0.39) compared to Group A (-0.20; 95% CI: -0.29 to -0.11), p = 0.032. Subjective parameters improved more in the Godhum Satva group. Godhum Satva demonstrated comparable efficacy to calcium supplementation in improving BMD and subjective bone health indicators. The study suggests Godhum Satva as a viable, culturally acceptable alternative.

A Pilot Randomized, Controlled, Parallel-group Clinical Trial to Evaluate Efficacy of Wheat Extract (Triticum dicoccum) Versus Calcium Supplementation in Osteopenic Women