<div>The investigation was carried out to monitor changes in concentration of plasma adipokines in transition period of crossbred cows of high and medium body conditions during winter and summer seasons. For this study, 24 Karan-Fries cows, six each of medium body condition (MBC) and high body condition (HBC) were selected from National Dairy Research Institute (NDRI) livestock research centre in both the seasons. Blood samples were collected on 21st, 15th and 7th day prepartum, on day of calving and on 7th, 15th and 21st days postpartum. Concentration of leptin, adiponectin and resistin were estimated. Body condition score differed significantly (p &lt; 0.05) between MBC and HBC cows in both the seasons. Body condition score (BCS) losses are higher in HBC cows as compared to MBC cows during early postpartum period in both the seasons. In winter as well as summer seasons, plasma levels of all the studied parameters were higher in HBC cows as compared to MBC cows. Plasma concentrations of leptin (P = 0.03) differed significantly between HBC and MBC cows. In summer mean value of adiponectin differed significantly (P &lt;0.05) between day of calving and postpartum period in HBC cows but in case of MBC cows the mean differed significantly (P &lt; 0.05) between prepartum, day of calving and postpartum. Resistin differed non-significantly between HBC and MBC cows in winter as well as summer.&nbsp;</div>

<div>Changes in Plasma Concentration of Leptin, Adiponectin and Resistin in Karan-Fries Cows of High and Medium Body Conditions During Winter and Summer Seasons</div>

Background: This study aims to investigate the anti-obesity effect of GOE with adipokine (apelin and adiponectin) response at different doses (100 and 200 mg/kg) of GOE in normal healthy and obese rats with High-fat diet (HF). 
 
Methods: In this study, 36 adult male Wistar albino rats, aged between 8-10 weeks, were used. 6 groups were created, with 6 rats in each group: Control (C), Rat group without GOE and HF application, G100 (GOE 100 mg/kg group given with oral gavage route of administration (OGRA), G200 (GOE 200 mg/kg group given with OGRA), HFC&nbsp;(HF control group): no HF and no GOE group), HF100 (rats receiving HF were100 mg/kg graviola oil extract added to their diet), HF200 (rats receiving HF were 200 mg/kg graviola oil extract added to their diet). Blood samples were taken from the tail vein (vena caudalis) of all on days 0 and 60 of the study. Apelin and adiponectin levels in the serum samples were measured by ELISA method. 
 
Result:&nbsp; In the present study, a significant increase (p&lt;0.01) was observed in the mean serum apelin level in the HF groups at the end of the 60 day after HF induction, while a significant decrease (p&lt;0.01) was also detected in the adiponectin level. On the other hand, when examined in terms of BW, the most significant decrease due to GOE addition in the HF groups, i.e. the anti-obesity effect, was determined in the HFG200 mg/kg group (p&lt;0.01). As a result, it was concluded that GOE may be safe and beneficial when administered at a dose of 200 mg/kg in obesity-induced rats.

Changes in Plasma Concentration of Leptin, Adiponectin and Resistin in Karan-Fries Cows of High and Medium Body Conditions During Winter and Summer Seasons

Effect of Graviola Oil Extract on Anti-obesity Effect and Adipokine (Apelin and Adiponectin) Response in High Fat Diet-induced Obese Rats