A field experiment was conducted at Pantnagar during kharif 2008 to examine the effect of post-emergence herbicides in soybean on productivity, weed infestation and soil health. Treatments consisting of clodinafop-propargyl 8% EC at 80, 100 and 165 g a.i. ha-1, Na-acifluorfen 20% SL of 165 and 206.2 g a.i. ha-1, combination of clodinafop-propargyl 8% EC + Na-acifluorfen 16.5% SL at 80 + 165, 100 + 206.2 and 160 + 330 g a.i. ha-1, imazethapyr 10% SL at 100 g a.i. ha-1, weed free and weedy check were tested in RBD with 3 replications. The soybean variety used for the study was PS-1347. Treatment of weed free check was found best by recording highest nodulation, yield and yield attributes, N uptake and soil parameters. It was at par with imazethapyr 10% SL @ 100 g a.i. ha-1, the treatment that showed highest nodule and plant dry weight, weed control efficiency, grain yield (1975 kg ha-1), straw yield (2445 kg ha-1), N uptake (136.4 kg ha-1 in grain and 40.9 kg ha-1 in straw), soil organic carbon, available N, P, K, microbial counts and dehydrogenase activity among different herbicides treatments. Clodinafop-propargyl 8% EC + Na-acifluorfen 16.5% SL was also found effective in weed control with 100 + 206.2 g a.i. ha-1. It was comparable to imazethapyr 10% SL @ 100 g a.i. ha-1 in weed index, weed control efficiency, nodule dry weight, grain and straw yields, N uptake, soil organic C, available N and K, microbial counts and dehydrogenase activity. The highest net return of Rs. 39563 ha-1 was obtained with weed free check, which was at par with imazethapyr 10% SL @ 100 g a.i. ha-1 and Clodinafop-propargyl 8% EC + Na-acifluorfen 16.5 SL @ 100 + 206.2 g ai ha-1.