Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 53 issue 10 (october 2019) : 1361-1366

Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs

Ertugrul Erhan, Renad Mammadov, Durdu Altuner, Ferda Keskin Cimen, Nezahat Kurt, Fazil Hacimuftuoglu, Fatih Turan, Suat Terzi, Metin Celiker, Halis Suleyman
1<p>Department of Pharmacology, Faculty of Medicine,&nbsp;Erzincan University, Erzincan, Turkey.</p>
Cite article:- Erhan Ertugrul, Mammadov Renad, Altuner Durdu, Cimen Keskin Ferda, Kurt Nezahat, Hacimuftuoglu Fazil, Turan Fatih, Terzi Suat, Celiker Metin, Suleyman Halis (2017). Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs . Indian Journal of Animal Research. 53(10): 1361-1366. doi: 10.18805/ijar.v0iOF.8483.

No previous studies have examined the effect of Hippophae rhamnoides fruit extract (HRE), which contains both water and fat soluble vitamins, on cisplatin-induced ototoxicity. Therefore, the aim of the study was to investigate the effects of HRE on cisplatin-induced ototoxicity in Guinea pigs and to evaluate the biochemical, gene expression and histopathological changes associated with cisplatin use. Experimental animals were divided into three groups: healthy (HG), HRE+cisplatin (HRC) and cisplatin control (CCG) groups. Biochemical, gene expression and histopathological examinations were carried on the removed inner ear tissues. In the HRC group, the oxidant parameter was lower and the anti-oxidant parameter was higher than in the CCG. These results are supported by gene expression levels and histopathological results. The use of HRE against cisplatin-induced oxidative ototoxicity may be easier, more cost effective and more beneficial than the use of vitamins alone or in combination with each other.


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