Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 51 issue 5 (october 2017) : 927-931

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

Nazli Ercan, Beran Yokus, M. Can Gûn, Akin Koçhan
1<p><br /> Department of Biochemistry,&nbsp;Cumhuriyet University Faculty of Veterinary Medicine, Sivas, Turkey.</p>
Cite article:- Ercan Nazli, Yokus Beran, G&ucirc;n Can M., Ko&ccedil;han Akin (2017). Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows . Indian Journal of Animal Research. 51(5): 927-931. doi: 10.18805/ijar.v0iOF.8459.

In healthy and complicated pregnant cows, on the 2nd and 6th months of pregnancy in order to determine the levels of maternal serum Paraoxonase 1 (PON1) activity and the possibility of complications can occur during the pregnancy might be a premise indication. Serum samples were taken at 2nd and 6th months of 252 pregnant cows at the end of their pregnancies. The cows were classified into two groups such as complicated (Abortion, Dystocia) and non-complicated. Maternal serum PON1 activity in 6th months was lower at complicated group than normally pregnant group (P=0.004; P<0.01), no difference was discovered between these groups in their 2nd month of pregnancy (P>0.05). Among the concentration of HDL, TP and globulin no statistical difference was observed between complicated, subgroups and normal births (P>0.05). Levels of PON1 in 2 and 6 months were statistically different between the groups of dystocia and normal pregnancy (P<0.01; P = 0.003), and abort and normal pregnancy (P<0.05; P=0.033). In this study, it was inferred that the evaluation of PON1 activity early indicator of complications for clinicians that might occur in further periods of pregnancy. These results showed the fact that PON1 activity can be used as a marker relatively at the early phases of pregnancy in complicated cows. 

  1. Abeni, F., Bergoglio, G., Masoero,G., Terzano, G.M. and Allegrini.S. (2004). Plasma hormones and metabolites in Piedmontese cows during late pregnancy: Relationships with calf birth weight. J Anim Sci, 82, 438– 444.

  2. Alaçam, E. (2010). Evcil hayvanlarda doðum ve infertilite. Medisan ISBN. 975-7774-37-5, p:131.

  3. Atamer, Y., Kocyigit,Y., Yokus,B., Atamer, A., and Erden.A.C. (2005). Lipid Peroxidation, Antioxidant Defense,status of Trace Metals and Leptin levels in Preeclampsia. Europ. J. Obstet. Gynecol. Reprod. Biol., 119, 60-66.

  4. Bademkiran, S., Yokus, B., Cakir, D.U., Durak, M.H. and Kurt. D.(2008). Serum paraoxonase 1 activity in dairy cattle and its association with dystocia. J Anim Vet Adv, 7, 1184- 1189.

  5. Brzezinska-Slebodzinska, E., Miller, J.K., Quigley, J.D., Moore, J.R., and Madsen. F.C. (1994). Antioxidant status of dairy cows supplemented prepartum with vitamin E and selenium. J. Dairy Sci. 77, 3087-3095.

  6. Castillo, C., Hernandez, J., Bravo, A., Lopez-Alonso, M., Pereira,V. and Benedito. J.L. (2005). Oxidative status during late pregnancy and early lactation in dairy cows. Veterinary J. 169, 286-292.

  7. Castillo, C., Hernandez, J., Valverde, I., Pereira, V., Sotillo, J., Lopez, A.M. and Benedito. J.L. (2006). Plasma malondialdehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Res. Vet. Sci. 80, 133-139. 

  8. Davidge, S.T., Hubel, C.A., Brayden, R.D., Capeless, E.C. and McLaughlin. M.K.(1992). Sera antioxidant activity in uncomplicated and preeclamptic pregnancies. Obstet. Gynecol. 79, 897-901. 

  9. El-Salahy, E.M., Ahmet, M.I., El-Gharieb, A. and Tawfik.H. (2001).New scope in angiogenesis: role of vascular endothelial growth factor (VEGF), NO, lipid peroxidation, and vitamin E in the pathophysiology of preeclampsia among Egyptian females. Clin. Biochem, 34, 323-329.

  10. Erel. O. 2004. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin. Biochem, 37, 112-119. 

  11. Furlong, C.E., Richter, R.J., Seidel, S.L., Costa, L.G. and Matulsky.L.G.(1989). Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase. Anal Biochem 180: 242–247. 

  12. Gupta, S., Agarwal, A. and Sharma. R.K. (2005a). The Role of Placental Oxidative Stres and Lipid Peroxidation in Preeclampsia. Obstet. Gynecol. Survey 60, 807-815. 

  13. Gupta, S., Gupta, H.K. and Soni. J. (2005b). Effect of Vitamin E and selenium supplementation on concentrations of plasma cortisol and erythrocyte lipid peroxides and the incidence of retained fetal membranes in crossbred dairy cattle.Theriogenology, 64,1273-1286.

  14. Harma, M., Harma, M., andErel. O. (2005). Measurement of the total antioxidant response in preeclampsia with a novel automated method. Europ. J. Obstet. Gynecol. Reprod. Biol. 118, 47-51.

  15. Juretic, D., Motejlkova, A., Kunovic, B., Rekic, B., Flegar-Mestric, Z., Vujic, L., Mesic, R., Lukac-Bajalo, J. and Simen-Rudolf.J., (2006). Paraoxonase/arylesterase in serum of patients with type II diabetes mellitus. Acta Pharm, 56:59-68.

  16. Juretic, D., Tadijanovic, M., Rekic, B., Simeon-Rudolf, V., Reiner, E. and Baricic. M. (2001). Serum paraoxonase activies in hemodialysed uremic patients: cohort study. Croatian Med J, 42:146-150. 

  17. Kankofer, M. 2001. The levels of lipid peroxidation products in bovine retained and not retained placenta. Prostagl. Leukotr. Ess. Fatty Acids 64, 33-36. 

  18. Kocyigit, Y., Bayhan,G., Atamer, A. and Atamer.Y., (2004). Serum levels of leptin, insulin- -like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistance. Gynecol. Endocrinol.18: 341-348.

  19. Kumru, S., Aydin, S., Gursu, M.F. and Ozcan. Z. (2004).Changes of serum paraoxonase (an HDL-cholesterolassociated lipophilic antioxidant) and arylesterase activities in severe preeclamptic women. Europ. J. Obst. Gynecol. Reprod. Biol., 114: 177-181. 

  20. Miller J. K., Brzezinska-Slebodzinska. E., (1993). Oxidative Stress, Antioxidants and Animal Function. J. Dairy Sci. 76, 2812-2823. 

  21. Oakes, D.E., Parkinson, T.J., England.G.C.W., (2001). Arthur’s Veterinary Reproduction and Obstetrics, Eighth edition. Part three: Dystocia and other disorders associated with parturation. W.B. Saunders, London, 205-333 pp. 

  22. Osuagwuh, A.I., Taiwo, B.B., Ngere.L.O.,(1980). Crossbreeding in tropical sheep: Incidence of dystocia and parturition losses. Tropical Animal Health and Production. 12 (2) 85-89.

  23. Roberts, S.J. 1986. Veterinary Obstetrics and Genital Diseases (Theriogeology), chapter 7., The cause of Dystocia., Author    Woodstock, Vermount, 277-283 pp. 

  24. Roche, J.F., Mackey, D., Diskin. M.D., (2000) Reproductive management of postpartum cows. Anim. Reprod. Sci. 60-61: 703-712.

  25. Serdar, Z., Gur, E., Develioglu, O., Colakogullari, M., Dirican. M., (2002). Placental and decidual lipid peroxidation and antioxidant defenses in preeclampsia lipid peroxidation in preeclampsia. Pathophysiology 9, 21-25.

  26. Stec, A., Mitler, J.K., Finkelstein, E., Stec, J., Mueller, Thomas, D.G., F.J. and Keltner.D.G. (1991). Plasma total antioxidant status of periparturient cow with udder edema or retained placenta. J. Dairy Sci. 74, 240-245. 

  27. SPSS 2014. Inc., Chicago, IL version 22.00 IBM.

  28. Turk, R., Juretic, D., Geres, D., Turk, N., Rekic, B., Simeon Rudolf, V. and Svetina. A. (2004). Serum paraoxonase activity and lipid parameters in the early postpartum period of dairy cows. Res Vet Sci, 76, 57–61.

  29. Turk, R., Juretic, D., Geres, D., Turk, N., Rekic, B.,Simeon-Rudolf, V., Robic, M. and A., Svetina. (2005). Serum paraoxonase activity in dairy cows during pregnancy. Research in Veterinary Science. 79:15–18.

  30. Turk, R., Juretic, D., Geres, D., Svetina, A., Turk, N. and Flegar Mestric. Z., (2008). Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows. Anim Reprod Sci, 108, 98–106. 30. 

  31. Uriel, J. (1961) Charactérisation des cholinestérases et d’autres estérases cardoxylique après électrophorèse et immunoélectrophorèse en gelose I. Applications à l’étude des estérases du serum humain normal. Ann. Inst. Pasteur. 101:104–119.

  32. Uzun, H., Benian, A., Madazli, R., Topcuoglu, M.A., Aydin, S. and Albayrak. M. (2005). Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia. Gynecol. Obstet. Invest., 60: 195-200, 

  33. Yildiz, H., ªimºek H., Saat, N. and Yüksel. M. (2011). Effects of dytocia in lipid peroxidation and enzymatic and non-enzymatic antioxidants in crossbred dairy cows. Bull Vet Inst Pulawy, 55, 135-139.

  34. Yokus, B., Bademkiran, S. and Cakir. D.U.(2007). Total anti-oxidant capacity and oxidative stress in dairy cattle and their associations with dystocia. Medycyna Weterynaryjna, 63 (2): 167-171.

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