Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 56 issue 12 (december 2022) : 1547-1551

​Pharmacokinetic Disposition and Residue Status of Tilmicosin in Broiler Chicken after ‘In-Crop’ and ‘In-Water’ Administration

Sakthivel Duraisamy, Ramesh Srinivasan, Vinothini Prabhakaran, Karthick Venkatesh, Porteen, Sriram Padmanabhan
1Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 051, Tamil Nadu, India.
Cite article:- Duraisamy Sakthivel, Srinivasan Ramesh, Prabhakaran Vinothini, Venkatesh Karthick, Porteen, Padmanabhan Sriram (2022). ​Pharmacokinetic Disposition and Residue Status of Tilmicosin in Broiler Chicken after ‘In-Crop’ and ‘In-Water’ Administration. Indian Journal of Animal Research. 56(12): 1547-1551. doi: 10.18805/IJAR.B-4219.

ABSTRACT

Background: The aim is to study the pharmacokinetics and tissue residue status of tilmicosin after administration through ‘in-crop’ and ‘in-water’ routes and compare the effectiveness of the two routes and establish a suitable dosage regimen for treating Mycoplasma gallisepticum infection in broiler chicken.
Methods: The plasma pharmacokinetic disposition of tilmicosin in broiler chicken was investigated after administration orally by direct deposition at crop (25 mg/kg body weight) or drinking water (40 mg/kg b.wt.). Residues of tilmicosin in tissues of broiler chicken were assayed. The plasma and tissue concentrations of tilmicosin were analyzed by reverse-phase high-performance liquid chromatography (HPLC) method. The plasma concentration-time data was described by the non-compartmental model for both routes and pharmacokinetic parameters were calculated. The data were statistically analyzed by Mann-Whitney U test
Conclusion: The mean plasma concentrations of tilmicosin in two routes tested (in-crop, in-water) were effective above MIC reported for Mycoplasma gallisepticum (0.05 µg/ml) up to 24 h. In addition, the drug residue in lungs was found at desirable concentration up to 22 days. However, residues of tilmicosin in tissues were above the advocated maximum residue limit (MRL) till 18th day in muscle and liver and till 22nd day in kidney. The results of the study indicate that the antimycoplasmal drug tilmicosin can be therapeutically efficacious after administration in crop as well as in drinking water.

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