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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 12 (december 2019) : 1594-1598,   Doi: 10.18805/ijar.B-3709

Antioxidant Status in STZ-induced diabetic rats treated with Vanadium pentoxide nanoparticles
 

K
K. Vijay
R
R. Suresh
K
K. Loganathasamy
V
V. Narayanan
K
K. Pratheepa
K
K. Venkataraman
V
V. Pandiyan
1Department of Veterinary Biochemistry, Madras Veterinary College, Chennai-600 007, Tamil Nadu, India.
Cite article:- Vijay K., Suresh R., Loganathasamy K., Narayanan V., Pratheepa K., Venkataraman K., Pandiyan V. (2019). Antioxidant Status in STZ-induced diabetic rats treated with Vanadium pentoxide nanoparticles. Indian Journal of Animal Research. 53(12): 1594-1598. doi: 10.18805/ijar.B-3709.

ABSTRACT

Antioxidant status determines the susceptibility of tissues to the oxidative stress associated with diabetes and its complications; hence in the present study antioxidant status was explored in streptozotocin-induced diabetic rats treated with vanadium in the form of vanadium pentoxide nanoparticles. Vanadium pentoxide and vanadium pentoxide nanoparticles at the dose rate of 5mg/kg were administered orally in STZ (50mg/Kg) induced diabetic rats for 30 days and glimepiride (reference drug) was administered orally at the dose rate of 800 ìg/kg body weight. Vanadium pentoxide nanoparticles significantly reduced the blood glucose levels than the diabetic control and other treatment group of rats. On exploration of antioxidant status in liver, kidney and pancreas tissues, vanadium in the form of vanadium pentoxide nanoparticles outperformed the vanadium pentoxide by increasing the activities of the enzymes catalase, superoxide dismutase and glutathione peroxidase, and the concentration of reduced glutathione and by decreasing the lipid peroxide levels. The present study also showed that the restoration of antioxidant status by vanadium pentoxide nanoparticles is comparable with that of the reference drug. It can be concluded that vanadium pentoxide nanoparticles, due to its superior control over hyperglycemia and antioxidant properties, outperformed the vanadium pentoxide treatment in enhancing the antioxidant status in diabetic rats.

REFERENCES

  1. Alkaladi, A. Abdelazim, A.M. and Afifi, M. (2014). Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-    induced diabetic rats. Int. J. Mol. Sci., 15: 2015-2023.
  2. Baynes, J.W. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes., 40: 405-412. 
  3. Caliborne, A.L. (1985). Assay of catalase; In: Handbook of Oxygen Radical Research. (Ed. Greenward RA) CRC Press Baco-Raton. 
  4. Das, S. Vasisht, S. Snehalata, M. Das, N. and Srivastava, M. (2000) Correlation between total antioxidant status and lipid peroxidation in hypercholesterolemia. Curr. Sci., 78: 486.
  5. Domingo, J.L. Gomez, M. Sanchez, D.J. Llobet, J.M. and Keen, C.L. (1995). Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation. Mol. Cell. Biochem., 153: 233–240. 
  6. Kannan, P. Vijayaraj, A. Sesh, P.S.L. Narayanan, V. Thangavel, A. and Pandiyan, V. (2016). Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex. Indian J. Anim. Res., 50(1): 57-62.
  7. Keyshams, N. Fatemi, S.R. Najafzadehvarzi, H. and Ashrafi, A. (2013). Effect of ammonium vanadate nanoparticles on experimental diabetes and biochemical factors in male sprague-dawly rats. Zahedan. J. Res. Med. Sci., 15: 29-34.
  8. Klepac, N. Rudes, Z. and Klepac, R. (2005). Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes. Biomed. Pharmacother., 60: 32-35.
  9. Koyuturk, M. Tunali, S. Bolkent, S. and Yanardag, R. (2005). Effects of Vanadyl Sulfate on liver of Streptozotocin-Induced diabetic rats. Biol. Trace Elem. Res., 104: 233-360. 
  10. Lipinski, B. (2001). Pathophysiology of oxidative stress in diabetes mellitus. J. of Diab. and its Comp., 15: 203-210.
  11. Lowry, O.H. Rosebrough, N.J. Farr, A.L. and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J. of Bio. Chem., 193: 265-275.
  12. Marklund, S.L. and Marklund, G. (1974). Involvement of superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for superoxide dismutase. Eur. J. of Biochem., 47: 496-474.
  13. Matsubara, T. Marcu, S.M. Misra, P.H. and Dhalla, N.S. (1995). Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart. Mol. Cell Biochem., 153: 79-85.
  14. Moron, M.S. Dipierre, J.W. and Mannervik, B. (1979). Levels of glutathione, glutathione reductase and glutathione s-transferase activities in rat kidney and liver. Biochem. Biophys. Acta., 582: 67-78.
  15. Patel, D.K. Kumar, R. Laloo, D. and Hemalatha, S. (2012). Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic. Asian Pac J Trop Biomed., 2(5): 411-420.
  16. Placer, Z.A. Cushman, L.L. and Johnson, B.C. (1966). Estimation of product of lipid peroxidation (Malonyldialdehyde) in biochemical systems. Anal Biochem., 16: 359-364.
  17. Porte, D. and Schwartz, M.W. (1996). Diabetes complications: why is glucose potentially toxic? Science., 272: 699-700.
  18. Rajarajeswari, N. and Pari, L. (2011) Antioxidant role of coumarin on streptozotocin -nicotinamide-induced type II diabetic rats. J. Biochem. Mol. Toxicol., 25(6): 355-61.
  19. Ramachandran, B. Ravi, K. Narayanan, V. Kandaswamy, M. and Subramanian, S. (2004). Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats. Chemico-Biological Interactions., 149: 9-21.
  20. Rotruck, J.T. Pope, A.L. Gasther, H.E. Swanson, A.B. Hafeman, D.G. and Hoeksha, W.G. (1972). Selenium, Biochemical role as a component of glutathione peroxidase. Science., 179: 588-590.
  21. Sekar, N. William, S. Balasubramaniyam, N. Kamarajan, P. and Govindasamy, S. (1990). Optimization of sodium orthovanadate to treat streptozotocin-induced diabetic rats. J. Biosci. 15: 67-75.
  22. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Method 9th edition, Iowa State University Press, Ames. USA
  23. Suresh, R. Giribabu, K. Manigandan, R. Munusamy, S. Praveenkumar, S. Muthamizh, S. Stephen, A. and Narayanan, V. (2014). Doping of Co into V2O5 nanoparticles enhances photodegradation of methylene blue. J. Alloys Compd., 598: 151-160.
  24. Vijay, K. Suresh, R. Loganathasamy, K. Narayanan, V. Pandiyan, V. Satheesh Kumar, T. and Padmanath, K. (2018). Anti-diabetic effects of vanadium pentoxide and vanadium Pentoxide Nanoparticles in STZ-Induced diabetic rats. Int. J. Pure App. Biosci. 6(3): 460-467
  25. Yan, H. and Harding, J.J. (1997). Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochem J., 328: 599-605.
  26. Yanardag, R. Demirci, T. Ulkuseven, B. Bolkent, S. Tunali, S. and Bolkent, S. (2009). Synthesis, characterization and anti-diabetic properties of N1-2,4-dihydroxybenzylidene-N4-2-hydroxybenzylidene-S-ethylthiosemi carbaz idato - oxovanadium (IV). Eur. J. Med. Chem., 44: 818-826.
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 12 (december 2019) : 1594-1598,   Doi: 10.18805/ijar.B-3709

    Antioxidant Status in STZ-induced diabetic rats treated with Vanadium pentoxide nanoparticles
     

    K
    K. Vijay
    R
    R. Suresh
    K
    K. Loganathasamy
    V
    V. Narayanan
    K
    K. Pratheepa
    K
    K. Venkataraman
    V
    V. Pandiyan
    1Department of Veterinary Biochemistry, Madras Veterinary College, Chennai-600 007, Tamil Nadu, India.
    Cite article:- Vijay K., Suresh R., Loganathasamy K., Narayanan V., Pratheepa K., Venkataraman K., Pandiyan V. (2019). Antioxidant Status in STZ-induced diabetic rats treated with Vanadium pentoxide nanoparticles. Indian Journal of Animal Research. 53(12): 1594-1598. doi: 10.18805/ijar.B-3709.

    ABSTRACT

    Antioxidant status determines the susceptibility of tissues to the oxidative stress associated with diabetes and its complications; hence in the present study antioxidant status was explored in streptozotocin-induced diabetic rats treated with vanadium in the form of vanadium pentoxide nanoparticles. Vanadium pentoxide and vanadium pentoxide nanoparticles at the dose rate of 5mg/kg were administered orally in STZ (50mg/Kg) induced diabetic rats for 30 days and glimepiride (reference drug) was administered orally at the dose rate of 800 ìg/kg body weight. Vanadium pentoxide nanoparticles significantly reduced the blood glucose levels than the diabetic control and other treatment group of rats. On exploration of antioxidant status in liver, kidney and pancreas tissues, vanadium in the form of vanadium pentoxide nanoparticles outperformed the vanadium pentoxide by increasing the activities of the enzymes catalase, superoxide dismutase and glutathione peroxidase, and the concentration of reduced glutathione and by decreasing the lipid peroxide levels. The present study also showed that the restoration of antioxidant status by vanadium pentoxide nanoparticles is comparable with that of the reference drug. It can be concluded that vanadium pentoxide nanoparticles, due to its superior control over hyperglycemia and antioxidant properties, outperformed the vanadium pentoxide treatment in enhancing the antioxidant status in diabetic rats.

    REFERENCES

    1. Alkaladi, A. Abdelazim, A.M. and Afifi, M. (2014). Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-    induced diabetic rats. Int. J. Mol. Sci., 15: 2015-2023.
    2. Baynes, J.W. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes., 40: 405-412. 
    3. Caliborne, A.L. (1985). Assay of catalase; In: Handbook of Oxygen Radical Research. (Ed. Greenward RA) CRC Press Baco-Raton. 
    4. Das, S. Vasisht, S. Snehalata, M. Das, N. and Srivastava, M. (2000) Correlation between total antioxidant status and lipid peroxidation in hypercholesterolemia. Curr. Sci., 78: 486.
    5. Domingo, J.L. Gomez, M. Sanchez, D.J. Llobet, J.M. and Keen, C.L. (1995). Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation. Mol. Cell. Biochem., 153: 233–240. 
    6. Kannan, P. Vijayaraj, A. Sesh, P.S.L. Narayanan, V. Thangavel, A. and Pandiyan, V. (2016). Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex. Indian J. Anim. Res., 50(1): 57-62.
    7. Keyshams, N. Fatemi, S.R. Najafzadehvarzi, H. and Ashrafi, A. (2013). Effect of ammonium vanadate nanoparticles on experimental diabetes and biochemical factors in male sprague-dawly rats. Zahedan. J. Res. Med. Sci., 15: 29-34.
    8. Klepac, N. Rudes, Z. and Klepac, R. (2005). Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes. Biomed. Pharmacother., 60: 32-35.
    9. Koyuturk, M. Tunali, S. Bolkent, S. and Yanardag, R. (2005). Effects of Vanadyl Sulfate on liver of Streptozotocin-Induced diabetic rats. Biol. Trace Elem. Res., 104: 233-360. 
    10. Lipinski, B. (2001). Pathophysiology of oxidative stress in diabetes mellitus. J. of Diab. and its Comp., 15: 203-210.
    11. Lowry, O.H. Rosebrough, N.J. Farr, A.L. and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J. of Bio. Chem., 193: 265-275.
    12. Marklund, S.L. and Marklund, G. (1974). Involvement of superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for superoxide dismutase. Eur. J. of Biochem., 47: 496-474.
    13. Matsubara, T. Marcu, S.M. Misra, P.H. and Dhalla, N.S. (1995). Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart. Mol. Cell Biochem., 153: 79-85.
    14. Moron, M.S. Dipierre, J.W. and Mannervik, B. (1979). Levels of glutathione, glutathione reductase and glutathione s-transferase activities in rat kidney and liver. Biochem. Biophys. Acta., 582: 67-78.
    15. Patel, D.K. Kumar, R. Laloo, D. and Hemalatha, S. (2012). Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic. Asian Pac J Trop Biomed., 2(5): 411-420.
    16. Placer, Z.A. Cushman, L.L. and Johnson, B.C. (1966). Estimation of product of lipid peroxidation (Malonyldialdehyde) in biochemical systems. Anal Biochem., 16: 359-364.
    17. Porte, D. and Schwartz, M.W. (1996). Diabetes complications: why is glucose potentially toxic? Science., 272: 699-700.
    18. Rajarajeswari, N. and Pari, L. (2011) Antioxidant role of coumarin on streptozotocin -nicotinamide-induced type II diabetic rats. J. Biochem. Mol. Toxicol., 25(6): 355-61.
    19. Ramachandran, B. Ravi, K. Narayanan, V. Kandaswamy, M. and Subramanian, S. (2004). Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats. Chemico-Biological Interactions., 149: 9-21.
    20. Rotruck, J.T. Pope, A.L. Gasther, H.E. Swanson, A.B. Hafeman, D.G. and Hoeksha, W.G. (1972). Selenium, Biochemical role as a component of glutathione peroxidase. Science., 179: 588-590.
    21. Sekar, N. William, S. Balasubramaniyam, N. Kamarajan, P. and Govindasamy, S. (1990). Optimization of sodium orthovanadate to treat streptozotocin-induced diabetic rats. J. Biosci. 15: 67-75.
    22. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Method 9th edition, Iowa State University Press, Ames. USA
    23. Suresh, R. Giribabu, K. Manigandan, R. Munusamy, S. Praveenkumar, S. Muthamizh, S. Stephen, A. and Narayanan, V. (2014). Doping of Co into V2O5 nanoparticles enhances photodegradation of methylene blue. J. Alloys Compd., 598: 151-160.
    24. Vijay, K. Suresh, R. Loganathasamy, K. Narayanan, V. Pandiyan, V. Satheesh Kumar, T. and Padmanath, K. (2018). Anti-diabetic effects of vanadium pentoxide and vanadium Pentoxide Nanoparticles in STZ-Induced diabetic rats. Int. J. Pure App. Biosci. 6(3): 460-467
    25. Yan, H. and Harding, J.J. (1997). Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochem J., 328: 599-605.
    26. Yanardag, R. Demirci, T. Ulkuseven, B. Bolkent, S. Tunali, S. and Bolkent, S. (2009). Synthesis, characterization and anti-diabetic properties of N1-2,4-dihydroxybenzylidene-N4-2-hydroxybenzylidene-S-ethylthiosemi carbaz idato - oxovanadium (IV). Eur. J. Med. Chem., 44: 818-826.
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