Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 53 issue 10 (october 2019) : 1310-1315

Seasonal variation in oxidative stress markers of Murrah buffaloes in heavy metal exposed areas of Ludhiana

P.V. Yeotikar, S. Nayyar, C. Singh, C.S. Mukhopadhyay, S. Sodhi Kakkar, R. Jindal
1<div style="text-align: justify;">Department of Veterinary Physiology and Biochemistry, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana - 141 004, Punjab, India.</div>
Cite article:- Yeotikar P.V., Nayyar S., Singh C., Mukhopadhyay C.S., Kakkar Sodhi S., Jindal R. (2018). Seasonal variation in oxidative stress markers of Murrah buffaloes in heavy metal exposed areas of Ludhiana. Indian Journal of Animal Research. 53(10): 1310-1315. doi: 10.18805/ijar.B-3643.

ABSTRACT

The parameters related to oxidative stress and heavy metal levels were assessed during summer and winter seasons in buffaloes from environmentally exposed areas (n=60)  of Ludhiana district of Punjab (India) and control area  (n=40). Buffaloes of heavy metal exposed areas exhibited significantly (p<0.05) increased blood levels of Cr, Ni, As and Pb along with significantly (p<0.05) higher erythrocytic malondialdehyde (MDA) levels; whereas significant (p<0.05) decrease was observed in superoxide dismutase activity and the levels of reduced glutathione (GSH), vitamins C and E as compared to buffaloes from control area. The level of oxidative stress was higher in all buffaloes during summer as compared to winter as indicated by significantly (p<0.05) higher MDA level, and lower concentrations of GSH, vitamins C and E irrespective of the area. Blood Cr, Ni, As and Pb levels showed highly significant positive correlation (p<0.01) with MDA level but negative correlation with SOD activity and the concentrations of GSH, vitamins C and E. Thus, it may be concluded that buffaloes exposed to heavy metals encounter significant oxidative stress and potential to quench free radicals is compromised during summer.

REFERENCES

  1. Allen S E, Grimshaw H M and Rowland A P. (1986). Methods in Plant Ecology. Blackwell Scientific Publication, Oxford, London.
  2. Arslan H H, Aksu D S, Ozdemir S, Yavuz O, Or M E and Barutcu U B.(2011). Evaluation of the relationship of blood heavy metal, trace element levels and antioxidative metabolism in cattle which are living near the trunk road. Kafkas Univ. Veteriner Fakultesi Dergisi. 17 : 77-82.
  3. Baker, H. and Frank, O. (1968). Vitamin status in metabolic upsets. World Rev of Nutr Diet.9 :124-160
  4. Chabukdhara P.,Nayyar S., Mukhopadhyay C. and Jindal R (2014). Liver function profile as related to antioxidant status in summer stressed lactating buffaloes. Indian Vet .J. 91 (8) : 15-17.
  5. Coogan TP, Latta DM, Snow ET, Costa M.(1989). Toxicity and carcinogenicity of nickel compounds, In: Mc Clellan RO, Critical Reviews in Toxicology, 19 : 341-84.
  6. Dhaliwal R S and Chhabra S.(2016). Effect of heavy metals on oxidative stress parameters of cattle Inhabiting Buddha Nallah area of Ludhiana district of Punjab.J Vet Sci Technol. 7:5 1-3 
  7. Dhanalakshmi B. and Gawdaman G. (2012). Determination of heavy metals in goat milk through icp-oes, Asian J. Dairy & Food Res. 32(3): 186-190.
  8. Ellman G L. (1959). Tissue sulfhydryl group.Arch Biochem. Biophys.82: 70-77.
  9. El-Nekeety A A, El-Kady A A, Soliman M S, Hassan N S and Abdei-Wahhab M A.(2009). Protective effect of Aqualegia vulgaris (L.) against lead acetate-induced oxidative stress in rats. Food ChemToxicol47: 2209-15.
  10. Ercal N., Gurer-Orhan H. and Aykin-Burns N.(2001). Toxic Metals and Oxidative Stress Part-I: Mechanisms Involved in Metal Induced Oxidative Damage, Curr. Top.Med.Chem.1 (6): 529-539. 
  11. Flora S J S, Bhadauria S, Kannan G M and Singh N. (2007). Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review. Journal of Environmental Biology 28: 333-47.
  12. Flora G, Gupta D and Tiwari A. (2012). Toxicity of lead: a review with recent updates. Interdisciplinary Toxicology 5(2): 47-58.
  13. Ganaie A.H. Hooda O.K, Singh S, V, Ashutosh and Upadhyay R.C. (2013).Effect of vitamin C supplementation on immune status and oxidative stress inpregnant Murrah buffaloes during thermal stress. Indian J Anim Sci.83 (6) : 649–655.
  14. Golia EE, Dimirkou and Mitsios (2008). Levels of heavy metals pollution in different types of soil of central Greece. Bull Environ ContamToxicol. 80: 206-210.
  15. Herrera E and Barbas C (2001). Vitamin E: Action, metabolism and respectives, J Physiol Biochem,57: 43-56.
  16. Hundal HS, Kumar R, Singh D and Manchanda JS (2006). Available nutrient and heavy metal status of soils of Punjab, North West India. J Indian Soc Soil Sci. 54: 50-56.
  17. Joshi A., Kataria N.,Kataria A.K.,Pandey N., Asopa S., Sankhala L.N.,Pachaury R. and Khan S (2013).Stress related variations in serum vitamin E and C levels of Murrah buffaloes. J Stress PhysiolBiochem .9 (1): 28-34.
  18. Jozefczak M., Remans T., Vangronsveld J and Cuypers A.(2012).Glutathione Is a key player in Metal-Induced Oxidative Stress Defenses. Int. J. Mol. Sci.13: 3145-3175.
  19. Kayden, H. J., Chow C.K. and Bjornson L.K.( 1973).Spectrophotometric method for determination of tocopherol in red blood cells. J. Lipid Res.14:533-540.
  20. Kohen R and Nyska A. (2002).Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantitation.ToxicolPathol, 30: 6, 620–650
  21. Koivula M.J., Kanerva M.,Salminen J.P.,Nkinmaa M. and Eeva T.(2011). Metal pollution indirectly increases oxidative stress in greattit (Parus major) nestlings. Environ Res 111 : 362–370
  22. Kumar G.B. Nandan S.B.,Kumari A.T. and Sajeevan K (2014).Curative effect of Vitamin C on the variation in Biochemical and Histopathological Parameters Induced by Copper exposure in the Teleost Fish, Anabas testudineus(Bloch, 1792). J EnvtSci, Toxico and Food Tech. 8 (II) : 28-35
  23. Kumar M., Jindal R. and Nayyar S.(2011). Influence of heat stress on antioxidant status in Beetal goats. Ind J of small Ruminants. 17(2):178-181.
  24. Kumar M. and Padhy P.K.(2013).Oxidative stress and heavy metals: an appraisal with reference to environmental biology. Int. Res. J. Biological Sci. 2(10): 91-101.
  25. Lakhani P.,Jindal R and Nayyar S.(2016).Effect of heat stress on humoral immunity and its amelioration by amla powder (Emblicaofficinalis) supplementation in buffaloes. J AniRes .6( 3): 401-40.
  26. Litwiñczuk Z., Król J., Brodziak A. and Bar³owska J.(2011).Changes of protein content and its fractions in bovine milk from different breeds subject to somatic cell count. J. Dairy Sci. 94 :684–691.
  27. Miranda M, Lopez-Alonso ON, Castillo C, Hernandez J and Benedito JL. (2005).Effects of Moderate pollution on toxic and trace metal levels in calves from a polluted area of northern Spain. Environ Int. 31: 543-548.
  28. Misra M, Rodriguez RE, Kasprzak KS. (1990). Nickel induced lipid peroxidation in rat: Correlation with nickel effect on antioxidant defense systems. Toxicol 64: 1,17- 22.
  29. Mohora M, Greabu M, Muscurel C, Duþã C, Totan A . (2007). The sources and the targets of oxidative stress in the etiology of diabetic complications. Romanian J. Biophys., 17: 2, 63–84.
  30. Nishikimi M, Rao N A and Yagi K A.(1972). The occurance of superoxide anion in the Molecule oxygen. Biochem.Biophys. Res. Commun4: 12-19.
  31. Noctor G. and Foyer C.H. (1198). Ascorbate and Glutathione: Keeping Active Oxygen under Control, Annu. Rev. Plant Physiol. Plant Mol. Biol.49, 249–279.
  32. Odedara A.B., ChaudharyS.S.,Singh V., Patel P.A.,Puri G. and Kharad V.B.(2016).Effect of different temperature humidity indices on antioxidant parameters in Surti buffaloes. Indian J. Anim. Res., B-3177: 1-4.
  33. Placer ZA,CushmanLL and Johnson BC.(1966).Estimation of product of lipid peroxidation (malonyldialdehde) in biochemical systems. Anal.Biochem.16 (2): 359-64.
  34. Padilla, L., T. Matsui, Y. Kamiya, M. Kamiya, M. Tanaka, and H. Yano. 2006. Heat stress Decreases plasma vitamin C concentration in lactating cows. Livest. Sci.101:300 304
  35. Park C and Jeong J (2018). Synergistic cellular responses to heavy metal exposure: A Minireview. Biochim Biophys Acta. 1862 (7):1584-1591.
  36. Pathan M.M., Latif A., DasH., Siddique G.M., Vaidya M.M. and Kushwaha R.(2013). Assessment of oxidative stress around parturition by antioxidant vitamins in mehsana buffaloes. Indian J. Anim. Res., 47 (2): 156-159.
  37. Pinto E., Kutner T.S., Leita M.A., Okamoto O.K., Morse D. and Colepicolo P. (2003). Heavy metal-induced oxidative stress in algae.J. Phycol.39: 1008–1018.
  38. Qureshi I.Z. and Mahmood T (2010).Prospective role of ascorbic acid (vitamin C) in Attenuating hexavalent chromium-induced functional and cellular damage in rat thyroid. Tox.and Indu Health, 26(6): 349–359.
  39. Rashed MN and Soltan ME. (2005). Animal hair as biological indicator for heavy metal pollution in urban and rural areas. Environmental Monitoring and Assessment 110:1-3.
  40. Roy D., Das T.K. and Vaswani S. (2013). Arsenic: it’s extent of pollution and toxicosis: An Animal perspective. Vet World. 6 (1):53-58.
  41. Singh A, Sharma R K, Agrawal M and Marshall F M. (2010). Health risk assessment of heavy metals via dietary intake of foodstuffs from the waste water irrigated site of dry tropical area of India. Food Chem Toxicol. 48: 611-19.
  42. Sinha M, Manna P and Sil P C. (2008). Protective effect of arjunolic acid against arsenic- induced oxidative stress in mouse brain. J Biochem Mole Toxicol.22(1): 15-26.
  43. Södergren E. (2000). Lipid Peroxidation In Vivo, Evaluation and Application of Methods for measurement, ActaUniversitatisUpsaliensis, Comprehensive Summaries of Uppsala. Dissertations from the Faculty of Medicine 949, Uppsala, 78.
  44. Stratulat A., Ciornea E., Dumitru G., Cojocaru S.I. (2010). Data on the activity of Superoxide-dismutase and catalase in two summer-old C. tenopharayngodonidella Species. Research gate 177-182. 
  45. Sujatha V.,Korde J.P.,Rastogi S.K., Maini S., Ravikanth K. and Rekhe D.S.(2010). Amelioration of heat stress induced distrurbances of the antioxidant defense system in broilers.J. Vet. Med. Anim. Health. 2(3):18-28.
  46. Sunderman F W Jr, Marzouk A, Crisostomo MC, Weatherby DR. (1985). Electrotherm al atomic absorption spectrophotometry of nickel in tissue homogenates. Ann Clin Lab Sci .15: 299-307.
  47. S´ wiergosz-Kowalewska R. and HolewaI .(2006).Cadmium, zinc and iron interactions in the tissues of bank vole Clethrionomysglareolus after exposure to low and high doses of cadmium chloride. Bio Metals. 20:743–749.
  48. Tchounwou P.B.,Yedjou C.G.,Patlolla A.K. and Sutton D.J.(2012). Heavy metals toxicity and the environment.NIH Public Access .101: 133–164.
  49. Valko M, Morris H and Cronin M T D. 2005. Metals, toxicity and oxidative stress. Current Medicinal Chemistry 12: 1161-1208.
  50. Wu X., Cobbina S.J., Mao G., XuH., Zhang ZandYang L.(2016). A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ Sci Pollut Res. 23:8244-8259. 
  51. Yeotikar, P.V., Nayyar, S., Singh, C., Mukhopadhaya, C.S., Kakkar, S.S. and Jindal, R. (2018). Levels of heavy metals in drinking water, blood and milk of buffaloes during summer and winter seasons in Ludhiana, Punjab (India), Int. J. Pure App. Biosci. 6(2): 1265-1274. 
  52. Yujiang Shi, Fei Lan, Caitlin Matson, Peter Mulligan, Johnathan R. Whetstine, Philip A. Cole, Robert A. Casero, and Yang Shi,(2004). Histone demethylation mediated by the Nuclear Amine Oxidase Homolog LSD1 Cell, 119 : 941–953. 
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