Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 50 issue 2 (april 2016) : 143-147

Molecular characterization of Ovar-DRB1 exon2 gene in Garole sheep resilient to gastrointestinal nematodes 

C. Paswan*, L.L.L. Prince, R. Kumar, C.P. Swarnkar, D. Singh, S. Kumar
1<p>Central Sheep and Wool Research Institute, Avikanagar-304 501, India&nbsp;</p>
Cite article:- Paswan* C., Prince L.L.L., Kumar R., Swarnkar C.P., Singh D., Kumar S. (NaN). Molecular characterization of Ovar-DRB1 exon2 gene in Garole sheep resilient to gastrointestinal nematodes . Indian Journal of Animal Research. 50(2): 143-147. doi: 10.18805/ijar.6710.

ABSTRACT

Ovine MHC DRB1 exon 2 (Ovar-DRB1.2) gene is arguably one of the critical genes, responsible for disease resistance against parasite in animals. This study was carried out for indepth analysis of polymorphism in MHC DRB1.2 gene and to explore the underlying molecular mechanisms for the development of disease resistance in Garole. PCR-RFLP study revealed that the gene is polymorphic in nature. The frequency of allele ‘A’ for endonuclease SacI and Allele ‘B’ for endonuclease Hin1I were significantly higher in Garole population.

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