Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.43

  • SJR 0.263

  • Impact Factor 0.5 (2023)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Animal Research, volume 48 issue 2 (april 2014) : 204-206


P. Veena, R.V. Suresh Kumar, K.B.P. Raghavender, Ch.Srilatha, T.S.C. Rao
1Sri Venkateswara Veterinary University College of Veterinary Science, Tirupati- 517 502, India
Cite article:- Veena P., Kumar Suresh R.V., Raghavender K.B.P., Ch.Srilatha, Rao T.S.C. (2023). IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS. Indian Journal of Animal Research. 48(2): 204-206. doi: 10.5958/j.0976-0555.48.2.043.
Mammary gland tumors are the most common neoplasms in female dogs and represent the second most frequently recognized tumors in dogs. Incidence of mammary tumor is as high as 50 per cent of all neoplasms in female dogs as compared to breast cancer in women. The prevalence of Estrogen Receptor (ER) Progesterone Receptor (PR) has been reported to be mixed mammary tumor (2) to know the rate of proliferation. P53 mutation was evident in 5 (20.83%) of 24 CMTs. P53 mutation was evident in 27.2% of the tumors that were declared positive for either or one of the hormone receptors. 20% of adenocarcinomas (4) and 50% of solid carcinoma (1) were found positive for P53 immunoreactivity. None of the mixed mammary tumors could express the P53 positivity.
  1. Lee CH and Kweon OK (2002) Mutation of P53 tumor suppressor gene in spontaneous canine mammary tumors. J. Vet. Sci. 3: 321-325.
  2. Morris J and Dobson J (2001) Principles of Chemotherapy In: Small Animal Oncology. Blackwell Publications. pp. 39-49.
  3. Mulligan RM 1975. Mammary cancer in dogs : a study of 120 cases. Ame. J. Vet. Res. 36: 1391-1396
  4. Muto T, Wakui S, Takahashi H, Maekawa S, Masaoka T, Vshigome S and Furusat M 2000 P53 Gene mutations occurring in spontaneous benign and malignant mammary tumors of the dog. Vet. Pathol. 37: 248-253.
  5. Shi,S.R., Key, M.E and Kalra,K.L.(1991) antigen retrival in formalin fixed paraffin embedded tissues .an enhancementmethod for immunohistochemical staining bsed onmicrove oven heating of tissue sections. J. Histochem. Cytochem. 39: 741-748.
  6. Taylor,C,R.,and Cote,R.J. (1994) Immunomicroscopy; a Diagnostic Tool for the Surgical Pathologist.W.B. saunders Company,Philadelphia,

Editorial Board

View all (0)