Chief Editor:

M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

Frequency:Monthly

Indexing:

Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, ...

IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS

P. Veena, R.V. Suresh Kumar, K.B.P. Raghavender, Ch.Srilatha, T.S.C. Rao

Affiliations

¹Sri Venkateswara Veterinary University College of Veterinary Science, Tirupati- 517 502, India

Submitted|
First Online |
doi 10.5958/j.0976-0555.48.2.043

Cite article:- Veena P., Kumar Suresh R.V., Raghavender K.B.P., Ch.Srilatha, Rao T.S.C. (2025). IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS. Indian Journal of Animal Research. 48(2): 204-206. doi: 10.5958/j.0976-0555.48.2.043.

ABSTRACT

Mammary gland tumors are the most common neoplasms in female dogs and represent the second most frequently recognized tumors in dogs. Incidence of mammary tumor is as high as 50 per cent of all neoplasms in female dogs as compared to breast cancer in women. The prevalence of Estrogen Receptor (ER) Progesterone Receptor (PR) has been reported to be mixed mammary tumor (2) to know the rate of proliferation. P53 mutation was evident in 5 (20.83%) of 24 CMTs. P53 mutation was evident in 27.2% of the tumors that were declared positive for either or one of the hormone receptors. 20% of adenocarcinomas (4) and 50% of solid carcinoma (1) were found positive for P53 immunoreactivity. None of the mixed mammary tumors could express the P53 positivity.

KEYWORDS

REFERENCES

Lee CH and Kweon OK (2002) Mutation of P53 tumor suppressor gene in spontaneous canine mammary tumors. J. Vet. Sci. 3: 321-325.
Morris J and Dobson J (2001) Principles of Chemotherapy In: Small Animal Oncology. Blackwell Publications. pp. 39-49.
Mulligan RM 1975. Mammary cancer in dogs : a study of 120 cases. Ame. J. Vet. Res. 36: 1391-1396
Muto T, Wakui S, Takahashi H, Maekawa S, Masaoka T, Vshigome S and Furusat M 2000 P53 Gene mutations occurring in spontaneous benign and malignant mammary tumors of the dog. Vet. Pathol. 37: 248-253.
Shi,S.R., Key, M.E and Kalra,K.L.(1991) antigen retrival in formalin fixed paraffin embedded tissues .an enhancementmethod for immunohistochemical staining bsed onmicrove oven heating of tissue sections. J. Histochem. Cytochem. 39: 741-748.
Taylor,C,R.,and Cote,R.J. (1994) Immunomicroscopy; a Diagnostic Tool for the Surgical Pathologist.W.B. saunders Company,Philadelphia,

Disclaimer :

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Copyright :

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.