DOI: 10.5958/j.0976-0555.48.2.043    | Article Id: B-2212 | Page : 204-206
Citation :- IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS.Indian Journal Of Animal Research.2014.(48):204-206
P. Veena, R.V. Suresh Kumar, K.B.P. Raghavender, Ch.Srilatha and T.S.C. Rao
Address : Sri Venkateswara Veterinary University College of Veterinary Science, Tirupati- 517 502, India


Mammary gland tumors are the most common neoplasms in female dogs and represent the second most frequently recognized tumors in dogs. Incidence of mammary tumor is as high as 50 per cent of all neoplasms in female dogs as compared to breast cancer in women. The prevalence of Estrogen Receptor (ER) Progesterone Receptor (PR) has been reported to be mixed mammary tumor (2) to know the rate of proliferation. P53 mutation was evident in 5 (20.83%) of 24 CMTs. P53 mutation was evident in 27.2% of the tumors that were declared positive for either or one of the hormone receptors. 20% of adenocarcinomas (4) and 50% of solid carcinoma (1) were found positive for P53 immunoreactivity. None of the mixed mammary tumors could express the P53 positivity.


Canine mammary tumors Immunohistochemical detection P53 Proliferative marker.


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