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Indian Journal of Animal Research, volume 48 issue 2 (april 2014) : 204-206

IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS

P. Veena, R.V. Suresh Kumar, K.B.P. Raghavender, Ch.Srilatha, T.S.C. Rao

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¹Sri Venkateswara Veterinary University College of Veterinary Science, Tirupati- 517 502, India

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doi 10.5958/j.0976-0555.48.2.043

Cite article:- Veena P., Kumar Suresh R.V., Raghavender K.B.P., Ch.Srilatha, Rao T.S.C. (2024). IMMUNOHISTOCHEMICAL DETECTION OF P53 IN CANINE MAMMARY TUMORS. Indian Journal of Animal Research. 48(2): 204-206. doi: 10.5958/j.0976-0555.48.2.043.

ABSTRACT

Mammary gland tumors are the most common neoplasms in female dogs and represent the second most frequently recognized tumors in dogs. Incidence of mammary tumor is as high as 50 per cent of all neoplasms in female dogs as compared to breast cancer in women. The prevalence of Estrogen Receptor (ER) Progesterone Receptor (PR) has been reported to be mixed mammary tumor (2) to know the rate of proliferation. P53 mutation was evident in 5 (20.83%) of 24 CMTs. P53 mutation was evident in 27.2% of the tumors that were declared positive for either or one of the hormone receptors. 20% of adenocarcinomas (4) and 50% of solid carcinoma (1) were found positive for P53 immunoreactivity. None of the mixed mammary tumors could express the P53 positivity.

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REFERENCES

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