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Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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URINARY DISPOSITION OF AMIKACIN FOLLOWING A SINGLE INTRAVENOUS ADMINISTRATION IN GOATS

A.K. Agrawal, S.D. Singh, C. Jayachandran

Affiliations

¹Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna-BOO 014, India

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Cite article:- Agrawal A.K., Singh S.D., Jayachandran C. (2025). URINARY DISPOSITION OF AMIKACIN FOLLOWING A SINGLE INTRAVENOUS ADMINISTRATION IN GOATS. Indian Journal of Animal Research. 35(2): 123 - 125. doi: .

ABSTRACT

The disposition of amikacin in urine was studied after a single intravenous administration @ 10 mg/kg body weight in six healthy goats. The mean concentration of amikacin in the urine samples ranged from 0.24 ± 0.06 to 1037.0 ± 126.7 μg/ml over a period of 30 hours. The peak urine concentration (1037.0 ± 126.7 μg/ml) was recorded at 20 min. The drug appeared in the urine in therapeutic concentration (2 μg/ml) at 2.5 min and the mean therapeutic concentration persisted for 12 hr. Amikacin may be used @ 10 mg/kg intravenously at 12 hr intervals for treating urinary tract infections caused by susceptible bacteria in goats

KEYWORDS

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