volume 35 issue 2 (july to december 2001) :
KINETICS AND DISTRIBUTION OF CIPROFLOXACIN IN BIOLOGICAL FLUIDS OF GOATS AFTER INTRAMUSCULAR ADMINISTRATION
1Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna - 800 014, India.
ABSTRACT
Kinetic study of ciprofloxacin (4 mg/kg i.m.) in goats showed peak concentrations of 1.45±0.21 and 225.00±18.17 μg/ml in plasma and urine, respectively at 1 hr and 6.24±0.18 μg/ml in milk at 2 hr were attained. The therapeutic concentration (>0.12 μg/ml) was maintained upto 8, 12 and 36 hr in plasma, milk and urine. The mean absorption half life (t½ Ka), elimination half life (t½ β) and total body clearance (ClB) of 0.48±0.06 hr, 2.32±0.70 hr and 12.60±1.58 ml/kg/min were calculated. A high Vdarea of 2.48±0.26 L/kg obtained for this drug denotes that the drug is well distributed.
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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Published In
Indian Journal of Animal Research
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