Chief Editor:

M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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KINETICS AND DISTRIBUTION OF CIPROFLOXACIN IN BIOLOGICAL FLUIDS OF GOATS AFTER INTRAMUSCULAR ADMINISTRATION

Singh Chandra Shekhar, Singh S.D., Jayachandran C., Akhtar M.H., Singh M.K.

Affiliations

¹Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna - 800 014, India.

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Cite article:- Shekhar Singh Chandra, Singh S.D., Jayachandran C., Akhtar M.H., Singh M.K. (2025). KINETICS AND DISTRIBUTION OF CIPROFLOXACIN IN BIOLOGICAL FLUIDS OF GOATS AFTER INTRAMUSCULAR ADMINISTRATION. Indian Journal of Animal Research. 35(2): . doi: .

ABSTRACT

Kinetic study of ciprofloxacin (4 mg/kg i.m.) in goats showed peak concentrations of 1.45±0.21 and 225.00±18.17 μg/ml in plasma and urine, respectively at 1 hr and 6.24±0.18 μg/ml in milk at 2 hr were attained. The therapeutic concentration (>0.12 μg/ml) was maintained upto 8, 12 and 36 hr in plasma, milk and urine. The mean absorption half life (t½ Ka), elimination half life (t½ β) and total body clearance (ClB) of 0.48±0.06 hr, 2.32±0.70 hr and 12.60±1.58 ml/kg/min were calculated. A high Vdarea of 2.48±0.26 L/kg obtained for this drug denotes that the drug is well distributed.

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