Indian Journal of Animal Research, volume 38 issue 2 (july to december 2004) : 125 - 128

PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

Sudha Kumari, Jai Prakash Narain, H.N. Jha, C. Jayachandran, M.K. Singh

Affiliations

¹Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna - 800014, India

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Cite article:- Kumari Sudha, Narain Prakash Jai, Jha H.N., Jayachandran C., Singh M.K. (2025). PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION. Indian Journal of Animal Research. 38(2): 125 - 128. doi: .

ABSTRACT

Pharmacokinetics and distribution of enrofloxacin in plasma, milk and urine were studied after a single intravenous dose of 5 mg/kg in six healthy goats. Therapeutic concentration of ≥0.12 μg/ml was maintained up to 10, 30 and > 48 hr in plasma, milk and urine, respectively. The drug showed a distribution half life (t½ α) of 0.60±0.10 hr and elimination half life (t½ β) of 2.82±0.33 hr. A value of 1.11±0.22 for tissue to plasma concentration ratio (T ≈ P) and large volume of distribution (Vdarea) of 2.34±0.54 L/kg indicated that the drug is distributed well in different body tissues and fluids. A total body clearance value (Cls) of 9.40±1.36 ml/kg/min was observed.

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REFERENCES

A1treuther, P. (1987). Vet. Med. Rev., 2: 87-89.
Anadon et al. (1995). Am. J. Vet. Res., 56: 501-506.
Baggot, J.D. (1977). Principles of Drag Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.
I" Edn. W.B. Saunders Company, Philadelphia, 144-189. .
Bauditz, R. (1990). Enrofloxacin Clinical Evaluation in Several Animal Species-Veterinary Pharmacology, Toxicology
and Therapy in food producing animals. Budapest University of Veterinary Science, Unlpharrna Company
Ltd.
British Pharmacopoeia. (1980). Biological Assay of Antibiotics. Her Majesty's Stationary Office, University Press,
Cambridge, London.
Broome etal. (1991). Am.J. Vet, Res., 52: 1835·1841.
Cabanes et al. (1992). Am. J. Vet. Res., 53: 2090-2093.
Glbaldi, M. and Perrier, D. (1975). Pharmacokinetics. Marcel Dekker Inc., New York, 281-296.
Giguere et aJ. (1996). Am. J. Vet. Res., 57: 1025-1030.
Kaartinen et al. (1995). J. Vet. Pharmacal Ther., 18: 357-362.
Kanemaki et al. (1995). J. Jap. Vet. Med. Assoc., 48: 957-959.
Kung et al. (1993). J. Vet.Pharmacal. Ther., 16: 462-468.
Mengozzletal. (1996). Am. J. Vet. Res., 57: 1040-1043.
Norris, S. and Mandell, G.L. (1988). In: The Quinolones. (Andriole, V.T. ed.), Acadeinlc Press Inc., New York.
Notari, R.E. (1980). Biopharmaceutics and Clinical Pharmacokinetics. 3nl ed. Marcell Dekker Inc., New York, 45-106.
Scheer, M. (1987). Vet. Med. Rev., 2: 90-99.

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PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

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