PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

Sudha Kumari; Jai Prakash Narain; H.N. Jha; C. Jayachandran; M.K. Singh

Indian Journal of Animal Research

Chief EditorM. R. Saseendranath
Print ISSN 0367-6722
Online ISSN 0976-0555
NAAS Rating 6.40
SJR 0.233, CiteScore (0.606)
Impact Factor 0.4 (2024)

Frequency :

Monthly (January, February, March, April, May, June, July, August, September, October, November and December)

Indexing Services :

Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus

Submit

Indian Journal of Animal Research, volume 38 issue 2 (july to december 2004) : 125 - 128

PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

Sudha Kumari, Jai Prakash Narain, H.N. Jha, C. Jayachandran, M.K. Singh

Affiliations

¹Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna - 800014, India

Submitted|
First Online |
doi

Cite article:- Kumari Sudha, Narain Prakash Jai, Jha H.N., Jayachandran C., Singh M.K. (2025). PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION. Indian Journal of Animal Research. 38(2): 125 - 128. doi: .

ABSTRACT

Pharmacokinetics and distribution of enrofloxacin in plasma, milk and urine were studied after a single intravenous dose of 5 mg/kg in six healthy goats. Therapeutic concentration of ≥0.12 μg/ml was maintained up to 10, 30 and > 48 hr in plasma, milk and urine, respectively. The drug showed a distribution half life (t½ α) of 0.60±0.10 hr and elimination half life (t½ β) of 2.82±0.33 hr. A value of 1.11±0.22 for tissue to plasma concentration ratio (T ≈ P) and large volume of distribution (Vdarea) of 2.34±0.54 L/kg indicated that the drug is distributed well in different body tissues and fluids. A total body clearance value (Cls) of 9.40±1.36 ml/kg/min was observed.

KEYWORDS

REFERENCES

A1treuther, P. (1987). Vet. Med. Rev., 2: 87-89.
Anadon et al. (1995). Am. J. Vet. Res., 56: 501-506.
Baggot, J.D. (1977). Principles of Drag Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.
I" Edn. W.B. Saunders Company, Philadelphia, 144-189. .
Bauditz, R. (1990). Enrofloxacin Clinical Evaluation in Several Animal Species-Veterinary Pharmacology, Toxicology
and Therapy in food producing animals. Budapest University of Veterinary Science, Unlpharrna Company
Ltd.
British Pharmacopoeia. (1980). Biological Assay of Antibiotics. Her Majesty's Stationary Office, University Press,
Cambridge, London.
Broome etal. (1991). Am.J. Vet, Res., 52: 1835·1841.
Cabanes et al. (1992). Am. J. Vet. Res., 53: 2090-2093.
Glbaldi, M. and Perrier, D. (1975). Pharmacokinetics. Marcel Dekker Inc., New York, 281-296.
Giguere et aJ. (1996). Am. J. Vet. Res., 57: 1025-1030.
Kaartinen et al. (1995). J. Vet. Pharmacal Ther., 18: 357-362.
Kanemaki et al. (1995). J. Jap. Vet. Med. Assoc., 48: 957-959.
Kung et al. (1993). J. Vet.Pharmacal. Ther., 16: 462-468.
Mengozzletal. (1996). Am. J. Vet. Res., 57: 1040-1043.
Norris, S. and Mandell, G.L. (1988). In: The Quinolones. (Andriole, V.T. ed.), Acadeinlc Press Inc., New York.
Notari, R.E. (1980). Biopharmaceutics and Clinical Pharmacokinetics. 3nl ed. Marcell Dekker Inc., New York, 45-106.
Scheer, M. (1987). Vet. Med. Rev., 2: 90-99.

Disclaimer :

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Copyright :

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reviewed By

Share options

Editorial Board

View all ()

[
a1treuther_1987] A1treuther, P. (1987). Vet. Med. Rev., 2: 87-89.

[2] Anadon et al. (1995). Am. J. Vet. Res., 56: 501-506.

[3] Baggot, J.D. (1977). Principles of Drag Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.

[4] I" Edn. W.B. Saunders Company, Philadelphia, 144-189. .

[5] Bauditz, R. (1990). Enrofloxacin Clinical Evaluation in Several Animal Species-Veterinary Pharmacology, Toxicology

[6] and Therapy in food producing animals. Budapest University of Veterinary Science, Unlpharrna Company

[7] Ltd.

[8] British Pharmacopoeia. (1980). Biological Assay of Antibiotics. Her Majesty's Stationary Office, University Press,

[9] Cambridge, London.

[10] Broome etal. (1991). Am.J. Vet, Res., 52: 1835·1841.

[11] Cabanes et al. (1992). Am. J. Vet. Res., 53: 2090-2093.

[12] Glbaldi, M. and Perrier, D. (1975). Pharmacokinetics. Marcel Dekker Inc., New York, 281-296.

[13] Giguere et aJ. (1996). Am. J. Vet. Res., 57: 1025-1030.

[14] Kaartinen et al. (1995). J. Vet. Pharmacal Ther., 18: 357-362.

[15] Kanemaki et al. (1995). J. Jap. Vet. Med. Assoc., 48: 957-959.

[16] Kung et al. (1993). J. Vet.Pharmacal. Ther., 16: 462-468.

[17] Mengozzletal. (1996). Am. J. Vet. Res., 57: 1040-1043.

[18] Norris, S. and Mandell, G.L. (1988). In: The Quinolones. (Andriole, V.T. ed.), Acadeinlc Press Inc., New York.

[19] Notari, R.E. (1980). Biopharmaceutics and Clinical Pharmacokinetics. 3nl ed. Marcell Dekker Inc., New York, 45-106.

[20] Scheer, M. (1987). Vet. Med. Rev., 2: 90-99.

PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

ABSTRACT

KEYWORDS

REFERENCES

Reviewed By

In this Article

APC

Publish With US

Become a Reviewer/Member

Open Access

Products and Services

Support and Policies

Editorial Board