Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 38 issue 2 (july to december 2004) : 125 - 128

PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION

Sudha Kumari, Jai Prakash Narain, H.N. Jha, C. Jayachandran, M.K. Singh
1Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna - 800014, India

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Cite article:- Kumari Sudha, Narain Prakash Jai, Jha H.N., Jayachandran C., Singh M.K. (2024). PHARMACOKINETICS AND DISTRIBUTION OF ENROFLOXACIN IN PLASMA, MILK AND URINE OF GOATS AFTER INTRAVENOUS ADMINISTRATION. Indian Journal of Animal Research. 38(2): 125 - 128. doi: .

ABSTRACT

Pharmacokinetics and distribution of enrofloxacin in plasma, milk and urine were studied after a single intravenous dose of 5 mg/kg in six healthy goats. Therapeutic concentration of ≥0.12 μg/ml was maintained up to 10, 30 and > 48 hr in plasma, milk and urine, respectively. The drug showed a distribution half life (t½ α) of 0.60±0.10 hr and elimination half life (t½ β) of 2.82±0.33 hr. A value of 1.11±0.22 for tissue to plasma concentration ratio (T ≈ P) and large volume of distribution (Vdarea) of 2.34±0.54 L/kg indicated that the drug is distributed well in different body tissues and fluids. A total body clearance value (Cls) of 9.40±1.36 ml/kg/min was observed.

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