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M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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THE TARGET ORGAN FOR VIRUS INDUCED CELLULAR TRANSFORMATION IN SUBGROUP A AND C ROUS SARCOMA VIRUS INFECTION IN LAYERS*

A.K. Ghosh**, P.K. Pani

Affiliations

¹Indian Veterinary Research Institute, Izatnagar - 243 122, India

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Cite article:- Ghosh** A.K., Pani P.K. (2025). THE TARGET ORGAN FOR VIRUS INDUCED CELLULAR TRANSFORMATION IN SUBGROUP A AND C ROUS SARCOMA VIRUS INFECTION IN LAYERS*. Indian Journal of Animal Research. 40(1): 46 - 48. doi: .

ABSTRACT

White leghorn (IWJ, IWG and IWC) embryos of 11-day-old were inoculated via the chorioallantoic
membrane (CAM) route with 0.2 ml of subgroup A and C Rous sarcoma viruses (RSVs), separately
containing 103 pfu/ml. Eggs were further incubated for hatching. The distribution of tumour lesions
in different organs was categorized in accordance with the pock count ranges (PCRs) and days of
survival. The liver was the target organ for the virus-induced cellular transformation for the avian
species because of the higher frequency and first appearance. The study conducted to investigate
the distribution pattern of visceral metastasis in subgroup A and C viral infection revealed that liver
was the most affected visceral organ followed by heart, lungs, spleen, kidney and gonads. The bursa of Fabricius and thymus were found to be tumour negative

KEYWORDS

REFERENCES

Dougherty, R.M. et al. (I960). Virology, 11: 349.
Dren, C.N. and Pani, P.K. (1977). J. Gen. Virol., 35: 13.
Ghosh, A.K. and Pani, P.K. (2002). Indian J. Exp. Biol., 40: 144.
Pani, P.K. et al. (1988). Avian Pathol., 17: 533.
Rout, P.K. (1989). M.V.Sc.Thesis. Indian Veterinary Research Institute, Deemed University, Izatnagar (UP).

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