volume 47 issue 5 (october 2013) : 386-391
HISTOPATHOLOGICAL CHANGES IN PIGS EXPOSED TO AFLATOXIN B1 DURING PREGNANCY
1Department of Veterinary Pathology
Veterinary College, Hebbal, Bangalore - 560024, India
ABSTRACT
The present study was undertaken to find out histopathological changes during experimental induction of aflatoxicosis in sows during pregnancy. In this experiment, 19 sows and 2 boars were used. The sows were divided in to three groups, consisting of control group without toxin in the feed. For treatment groups, aflatoxin was fed at 1 and 3 ppm respectively. The treated sows showed clinical signs of anorexia, jaundice and loss of body weight. The postmortem examination of the treatment groups revealed tannish discoloration of liver with insissated bile in the gall bladder and atrophied spleen. Histopathological examination of the liver revealed hypertrophy of the bile duct epithelium, dissociation of the liver cords, karyomegaly and extensive fibrosis with appearance of pseudolobulation in certain areas resulting in frank adenoma. Spleen showed depletion of lymphocytes in germinal epithelium area. Kidney showed prominent intertubular hemorrhages and atrophy of the glomeruli. The present study indicated hepatotoxic, nephrotoxic feature of the aflatoxin B1 in pregnant sows.
REFERENCES
- Buttler, W.H. and Wrigglesworth, J.S. (1966). Effect of AFB1 on the pregnant rats. Br. J. Experimental Path., 47: 242-247.
- Devegowda, G., Radu, M.V.L., Nazar, A. and Swamy, H.V.L.M. (1998). Mycotoxin picture worldwide: Novel solutions for their counteraction. Proceedings of Alltech’s 14th Annual Symposium on Biotechnology in Feed Industry: Passport of the Year 2000, (BFI=98), Nottingham University Press, pp 241-255.
- Harding,J.D., Done, J.T., Lewis, W. and Allcroft, R. (1963). Experimental groundnut poisoning in pigs. Res.Vet.Sci., 4: 217-229.
- Hayes,A.W., King, R.E., Ungar, P.D., Philips, T.D., Hatkin, J. and Bowman, J.H. (1978). Afflatoxicosis in swine. J. Am.Vet.Med. Association, 172: 1295-1297.
- Loosemore, R.M. and Markson, L.M. (1961). Poisoning of cattle by Brazilian groundnut meal. Vet.Rec., 73: 813-814.
- Luna, L.G. (1968). Manual of Histopathological Staining Methods of the Armed Forces Institute of Pathology. 3rd Edn. McGraw Hill Book Co, New York. p. 25-78.
- Miller, D.M., Stuart, B.P. and Crowell, W.A. (1981). Experimental afflatoxicosis in swine , morphological and clinical pathological results. Can.J.Comp.Med., 45: 343-351.
- Nair, G.M., Maryamma, K.I. and Rajan, A. 1988. Immunopathological response of pigs in affaltoxicosis. Kerala J.Vet.Sci., 19: 143-157.
- Paul, M., Newberne, H. and William, H.B. (1969). Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals. Rev. Cancer Res., 29:236-250.
- Shotwell, O.L., Hesseltine, G.W., Subblefield, R.D. and Sorenson, W.G. (1966). Production of aflatoxin on rice. Appl. Microbiol., 14: 425-428.
- Sisk, D.B., Carlton, W. W. and Curtin, T.M. (1968). Experimental afflatoxoicosis in swine. Am.J.Vet. Res., 29(8): 151- 158.
Disclaimer :
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Copyright :
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Published In
Indian Journal of Animal Research
Article Metrics
0
Views
Citations
Reviewed By
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
