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Current IssueEditorial BoardOnline First ArticlesArchive

volume 43 issue 3 (september 2009) : 173-177

IMPACT OF LEAD ON CLINICOHEMATOLOGICAL PARAMETERS AFTER DIETARY ORAL ADMINISTRATION AND PROTECTIVE EFFICACY OF TULSI (OCIMUM SANCTUM) IN COCKERELS

A
Atul Prakash1
S
S. P. Singh2
R
Rachna Varma
G
G. K. Choudhary
1College of Veterinary Science and Animal Husbandry N. D. University of Agriculture & Technology, Kumarganj, Faizabad- 224229, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Prakash1 Atul, Singh2 P. S., Varma Rachna, Choudhary K. G. (2025). IMPACT OF LEAD ON CLINICOHEMATOLOGICAL PARAMETERS AFTER DIETARY ORAL ADMINISTRATION AND PROTECTIVE EFFICACY OF TULSI (OCIMUM SANCTUM) IN COCKERELS. Indian Journal of Animal Research. 43(3): 173-177. doi: .

ABSTRACT

The study was conducted in thirty-five, four weeks old male white leghorn chicks. They were
randomly divided into five groups i.e. I (control), II (lead 50 ppm), III (lead 100 ppm), IV (lead
50 ppm + tulsi 100 ppm) and V (lead 100 ppm + tulsi 100 ppm) of seven birds each. The clinical
and hematological changes were studied following 12 weeks feeding trial. There were no apparent
clinical sign in treated group but there were a significant (p < 0.01) decline in total erythrocyte
count (TEC, x 106/mm3), hemoglobin (g/dl) and TLC (103 / mm3) in the chicks fed on 50 ppm and
100 ppm lead after 8 weeks onward in comparison to control and significantly (p < 0.01)
increases in lead + tulsi group. Lead alters the other hematological parameter but
simultaneous feeding of tulsi neutralizes the toxic effect of lead. Lead induces toxic effects
in cockerels but simultaneous feeding of tulsi can normalize the hematological status that
is due to protective efficacy of tulsi.

REFERENCES

  1. Blood, D. C. and Radostits, O. M. (1989). Veterinary Medicine. 7th Edn., Baillier Tindall, London.
  2. Donavic, W. J. (1966). J. Am. Vet. Med. Assoc. 148: 655-661.
  3. Geetha, R. and Vasudevan, D. M. (2004). Life Sci. 76: 21-28.
  4. Hatch, R. C. (1988). In: Veterinary Pharmacology and Therapeutics. 6th ed. (Booth, N. H. and Mc Donald, L.) E. Prima Publ. Corp. New Delhi. Pp 1083-1091.
  5. Jain, N. C. (1986). Schalm’s Veterinary Hematology. 4th Ed. Lea and Febriger, Philadelphia.
  6. Lee, J. E.; et al. (2002). Arch- Toxicol. 75: 717-724.
  7. Lucas, A. M. and Jamrog, C. (1961). Atlas of Avian Hematology. Govt. Printer, Washington, D.C.
  8. Maithi, S. K. and Swarup, D. (1990). Res. Vet. Sci. 48: 377-378.
  9. Mitchell, R. R. (2001). J. Wildl. Dis. 37: 459-467. Vol. 43, No. 3, 2009 177
  10. Natt, M. P. and Herrick, C. A. (1952). Poult. Sci. 31: 735-778.
  11. Paul, B.H. and Robert, P.B. (1980). In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. 2nd edn.
  12. Macmillon Publishing Co., Inc. New York. pp 417-418.
  13. Roger, C. Hatch (1982). In: Jones Veterinary Pharmacology and Therapeutics. 5th edn. Kalyani Publishers, New Delhi- Ludhiana. pp 976-1017.
  14. Somlay, I. et al., (1986). Allatorr Lapja, 41: 432-434.
  15. Surender, Singh et al., (2001). J Ethnopharmacology, 78: 139-143.
  16. Venugopal, B. and Luckey, T. D. (1978). Metal Toxicity in Mammals Vol. 2: Chemical Toxicity of Metals and Metalloids, Plenum New York:pp. 185.
  17. Yanpallewar, S.U. et al. (2004). Pharmacol, Biochem and Behavior. 79: 155-164.
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    volume 43 issue 3 (september 2009) : 173-177

    IMPACT OF LEAD ON CLINICOHEMATOLOGICAL PARAMETERS AFTER DIETARY ORAL ADMINISTRATION AND PROTECTIVE EFFICACY OF TULSI (OCIMUM SANCTUM) IN COCKERELS

    A
    Atul Prakash1
    S
    S. P. Singh2
    R
    Rachna Varma
    G
    G. K. Choudhary
    1College of Veterinary Science and Animal Husbandry N. D. University of Agriculture & Technology, Kumarganj, Faizabad- 224229, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Prakash1 Atul, Singh2 P. S., Varma Rachna, Choudhary K. G. (2025). IMPACT OF LEAD ON CLINICOHEMATOLOGICAL PARAMETERS AFTER DIETARY ORAL ADMINISTRATION AND PROTECTIVE EFFICACY OF TULSI (OCIMUM SANCTUM) IN COCKERELS. Indian Journal of Animal Research. 43(3): 173-177. doi: .

    ABSTRACT

    The study was conducted in thirty-five, four weeks old male white leghorn chicks. They were
    randomly divided into five groups i.e. I (control), II (lead 50 ppm), III (lead 100 ppm), IV (lead
    50 ppm + tulsi 100 ppm) and V (lead 100 ppm + tulsi 100 ppm) of seven birds each. The clinical
    and hematological changes were studied following 12 weeks feeding trial. There were no apparent
    clinical sign in treated group but there were a significant (p < 0.01) decline in total erythrocyte
    count (TEC, x 106/mm3), hemoglobin (g/dl) and TLC (103 / mm3) in the chicks fed on 50 ppm and
    100 ppm lead after 8 weeks onward in comparison to control and significantly (p < 0.01)
    increases in lead + tulsi group. Lead alters the other hematological parameter but
    simultaneous feeding of tulsi neutralizes the toxic effect of lead. Lead induces toxic effects
    in cockerels but simultaneous feeding of tulsi can normalize the hematological status that
    is due to protective efficacy of tulsi.

    REFERENCES

    1. Blood, D. C. and Radostits, O. M. (1989). Veterinary Medicine. 7th Edn., Baillier Tindall, London.
    2. Donavic, W. J. (1966). J. Am. Vet. Med. Assoc. 148: 655-661.
    3. Geetha, R. and Vasudevan, D. M. (2004). Life Sci. 76: 21-28.
    4. Hatch, R. C. (1988). In: Veterinary Pharmacology and Therapeutics. 6th ed. (Booth, N. H. and Mc Donald, L.) E. Prima Publ. Corp. New Delhi. Pp 1083-1091.
    5. Jain, N. C. (1986). Schalm’s Veterinary Hematology. 4th Ed. Lea and Febriger, Philadelphia.
    6. Lee, J. E.; et al. (2002). Arch- Toxicol. 75: 717-724.
    7. Lucas, A. M. and Jamrog, C. (1961). Atlas of Avian Hematology. Govt. Printer, Washington, D.C.
    8. Maithi, S. K. and Swarup, D. (1990). Res. Vet. Sci. 48: 377-378.
    9. Mitchell, R. R. (2001). J. Wildl. Dis. 37: 459-467. Vol. 43, No. 3, 2009 177
    10. Natt, M. P. and Herrick, C. A. (1952). Poult. Sci. 31: 735-778.
    11. Paul, B.H. and Robert, P.B. (1980). In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. 2nd edn.
    12. Macmillon Publishing Co., Inc. New York. pp 417-418.
    13. Roger, C. Hatch (1982). In: Jones Veterinary Pharmacology and Therapeutics. 5th edn. Kalyani Publishers, New Delhi- Ludhiana. pp 976-1017.
    14. Somlay, I. et al., (1986). Allatorr Lapja, 41: 432-434.
    15. Surender, Singh et al., (2001). J Ethnopharmacology, 78: 139-143.
    16. Venugopal, B. and Luckey, T. D. (1978). Metal Toxicity in Mammals Vol. 2: Chemical Toxicity of Metals and Metalloids, Plenum New York:pp. 185.
    17. Yanpallewar, S.U. et al. (2004). Pharmacol, Biochem and Behavior. 79: 155-164.
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