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Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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HYPOGLYCAEMIC EFFECT OF PLEUROTUS OSTREATUS IN RATS

L. Saritha Krishna, P.T.A. Usha, , A.M. Chandrasekhara Nair

Affiliations

¹Department of Veterinary Pharmacology and Toxicology College of Veterinary and Animal Sciences Mannuthy, Thrissur, Kerala - 680 651, India

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Cite article:- Krishna Saritha L., Usha P.T.A., Nair Chandrasekhara A.M. (2025). HYPOGLYCAEMIC EFFECT OF PLEUROTUS OSTREATUS IN RATS. Indian Journal of Animal Research. 43(2): 139-141. doi: .

ABSTRACT

The study was conducted to assess the hypoglycaemic effect of Pleurotus ostreatus in alloxan
diabetic rats. Three dose levels of Pleurotus ostreatus (250, 500 and 1000 mg/kg) were tested in
rats. All the alloxan diabetic rats showed decrease in body weight. Administration of Pleurotus
ostreatus resulted in increasing body weight in a dose dependent manner. A dose dependent
decrease in blood glucose level was obtained with P. ostreatus at doses of 250, 500 and 1000 mg/
kg. The increased serum cholesterol level observed in alloxan diabetic animals was reversed with
the administration of P. ostreatus. The lowest serum cholesterol level was observed with 1000
mg/kg of P. ostreatus. All the experimental groups showed reduction in the serum triglyceride
level but the most significant result (P0.05) was shown by Group V. The diabeti animals
showed a significant decrease (P0.05) in liver glycogen level bt the liver glycogen level was
.significantly increased (P0.05) when treated with P.ostreatus. The present study revealed
hypoglycaemic and hypolipidemic effect of P. ostreatus

KEYWORDS

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