EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

M. Anil Kumar*; M. Krishna Reddy; M. Sarangapani

Indian Journal of Animal Research

Chief EditorM. R. Saseendranath
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Indian Journal of Animal Research, volume 44 issue 2 (june 2010) : 135 - 138

EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

M. Anil Kumar*, M. Krishna Reddy, M. Sarangapani

Affiliations

¹Department of Zoology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, India.

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Cite article:- Kumar* Anil M., Reddy Krishna M., Sarangapani M. (2025). EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS. Indian Journal of Animal Research. 44(2): 135 - 138. doi: .

ABSTRACT

The present study is designed to study the effect of a new heterocyclic compound on
glycogen, pyruvate and lactic acid contents in tissues to understand the carbohydrate metabolism
and its role in male rats. The treatment with ethyl -1 -(5 –chloro -2 –oxoindolin -3
ylideneamino) -1,2,3,6 –tetrahydro - 4 -methyl -2 -oxo -6 –phenyl pyrimidine -5 -carboxylate
compound at dose level of 3 mg/kg/b.wt. for 21 days did cause a mild change in carbohydrate
metabolism in reproductive and somatic tissues of treated rats. In order to assess physiological
changes in testis, brain, heart, kidney and liver of rats, estimation of glycogen, pyruvate and
lactic acid has been under taken. The result showed a mild decrease in glycogen and lactate
levels but in contrast, same treatment caused a mild increase in pyruvate levels

KEYWORDS

REFERENCES

Ajitha, M. (2009). Ph.D.Thesis, Kakatiya University, Warangal, India.
Anil Kumar, M. (2009). Asian J. BioSci. 4(2): 235-240.
Annison, E.F. et al. (1963). Biochemical J. 88: 482.
Barker, S.H. and Summerson, W.H. (1941). J. Biol. Chem. 138: 535-554.
Bell, G.H. et al. (1972). Text Book of Physiology and Biochemistry, 18th Edn., Elbs and Churchill Livingston,
U.K.
Berry, L.J. and Smythe, D.S. (1959). Am. J. Physiol. 197: 37-40.
Eshete, F. and Bennett, J.L. (1990). Expt. Parasitol. 91(1): 69-80.
Friedman, T.E. and Haugen, G.E. (1943). J. Biol. Chem. 144: 67-77.
Harper, H.A. et al. (1977). In Review of Physiological Chemistry,
16th Edn., Langer, Med. Publications, California.
Huckbee, W.E. (1961). In Hawkis Physiological Chemistry, 14th Edn, (Ed. Oser, B.L.), New Delhi, Tata MC
Graw-Hill. 1108.
Jagadeesan, G. and Mathivanan, A. (1999). Poll. Res. 18(2): 177-181.
Klicpera, M. et al. (1957). Physiol. Bohemoslov. 6: 569.
Lang, S. and Lin, Y. (1984). In: Comprehensive Heterocyclic Chemistry, (Eds. Katrizky, A.R. and Rees,
C.W.) Peragamon Press, Oxford. 6, 1-130.
Neff, C.M. et al. (1987). Arctics. 40 (1): 220-229.
Rastogi, R. et al. (1997). Drug Dev. Res. 41: 44.
Samba Siva Rao, K.R.S. (1999). Pesticide impact on fish metabolism Discovery Publishing House, New
Delhi, India, 66-70.
Umminger, B.L. (1977). Comp. Biochem, Physiol. 55: 410- 416

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[
ajitha_2009] Ajitha, M. (2009). Ph.D.Thesis, Kakatiya University, Warangal, India.

[2] Anil Kumar, M. (2009). Asian J. BioSci. 4(2): 235-240.

[3] Annison, E.F. et al. (1963). Biochemical J. 88: 482.

[4] Barker, S.H. and Summerson, W.H. (1941). J. Biol. Chem. 138: 535-554.

[5] Bell, G.H. et al. (1972). Text Book of Physiology and Biochemistry, 18th Edn., Elbs and Churchill Livingston,

[6] U.K.

[7] Berry, L.J. and Smythe, D.S. (1959). Am. J. Physiol. 197: 37-40.

[8] Eshete, F. and Bennett, J.L. (1990). Expt. Parasitol. 91(1): 69-80.

[9] Friedman, T.E. and Haugen, G.E. (1943). J. Biol. Chem. 144: 67-77.

[10] Harper, H.A. et al. (1977). In Review of Physiological Chemistry,

[11] 16th Edn., Langer, Med. Publications, California.

[12] Huckbee, W.E. (1961). In Hawkis Physiological Chemistry, 14th Edn, (Ed. Oser, B.L.), New Delhi, Tata MC

[13] Graw-Hill. 1108.

[14] Jagadeesan, G. and Mathivanan, A. (1999). Poll. Res. 18(2): 177-181.

[15] Klicpera, M. et al. (1957). Physiol. Bohemoslov. 6: 569.

[16] Lang, S. and Lin, Y. (1984). In: Comprehensive Heterocyclic Chemistry, (Eds. Katrizky, A.R. and Rees,

[17] C.W.) Peragamon Press, Oxford. 6, 1-130.

[18] Neff, C.M. et al. (1987). Arctics. 40 (1): 220-229.

[19] Rastogi, R. et al. (1997). Drug Dev. Res. 41: 44.

[20] Samba Siva Rao, K.R.S. (1999). Pesticide impact on fish metabolism Discovery Publishing House, New

[21] Delhi, India, 66-70.

[22] Umminger, B.L. (1977). Comp. Biochem, Physiol. 55: 410- 416

EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

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