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Current IssueEditorial BoardOnline First ArticlesArchive

volume 44 issue 2 (june 2010) : 135 - 138

EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

M
M. Anil Kumar*
M
M. Krishna Reddy
M
M. Sarangapani
1Department of Zoology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Kumar* Anil M., Reddy Krishna M., Sarangapani M. (2025). EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS. Indian Journal of Animal Research. 44(2): 135 - 138. doi: .

ABSTRACT

The present study is designed to study the effect of a new heterocyclic compound on
glycogen, pyruvate and lactic acid contents in tissues to understand the carbohydrate metabolism
and its role in male rats. The treatment with ethyl -1 -(5 –chloro -2 –oxoindolin -3
ylideneamino) -1,2,3,6 –tetrahydro - 4 -methyl -2 -oxo -6 –phenyl pyrimidine -5 -carboxylate
compound at dose level of 3 mg/kg/b.wt. for 21 days did cause a mild change in carbohydrate
metabolism in reproductive and somatic tissues of treated rats. In order to assess physiological
changes in testis, brain, heart, kidney and liver of rats, estimation of glycogen, pyruvate and
lactic acid has been under taken. The result showed a mild decrease in glycogen and lactate
levels but in contrast, same treatment caused a mild increase in pyruvate levels

REFERENCES

  1. Ajitha, M. (2009). Ph.D.Thesis, Kakatiya University, Warangal, India.
  2. Anil Kumar, M. (2009). Asian J. BioSci. 4(2): 235-240.
  3. Annison, E.F. et al. (1963). Biochemical J. 88: 482.
  4. Barker, S.H. and Summerson, W.H. (1941). J. Biol. Chem. 138: 535-554.
  5. Bell, G.H. et al. (1972). Text Book of Physiology and Biochemistry, 18th Edn., Elbs and Churchill Livingston,
  6. U.K.
  7. Berry, L.J. and Smythe, D.S. (1959). Am. J. Physiol. 197: 37-40.
  8. Eshete, F. and Bennett, J.L. (1990). Expt. Parasitol. 91(1): 69-80.
  9. Friedman, T.E. and Haugen, G.E. (1943). J. Biol. Chem. 144: 67-77.
  10. Harper, H.A. et al. (1977). In Review of Physiological Chemistry,
  11. 16th Edn., Langer, Med. Publications, California.
  12. Huckbee, W.E. (1961). In Hawkis Physiological Chemistry, 14th Edn, (Ed. Oser, B.L.), New Delhi, Tata MC
  13. Graw-Hill. 1108.
  14. Jagadeesan, G. and Mathivanan, A. (1999). Poll. Res. 18(2): 177-181.
  15. Klicpera, M. et al. (1957). Physiol. Bohemoslov. 6: 569.
  16. Lang, S. and Lin, Y. (1984). In: Comprehensive Heterocyclic Chemistry, (Eds. Katrizky, A.R. and Rees,
  17. C.W.) Peragamon Press, Oxford. 6, 1-130.
  18. Neff, C.M. et al. (1987). Arctics. 40 (1): 220-229.
  19. Rastogi, R. et al. (1997). Drug Dev. Res. 41: 44.
  20. Samba Siva Rao, K.R.S. (1999). Pesticide impact on fish metabolism Discovery Publishing House, New
  21. Delhi, India, 66-70.
  22. Umminger, B.L. (1977). Comp. Biochem, Physiol. 55: 410- 416
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    volume 44 issue 2 (june 2010) : 135 - 138

    EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS

    M
    M. Anil Kumar*
    M
    M. Krishna Reddy
    M
    M. Sarangapani
    1Department of Zoology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, India.

    • Submitted|

    • First Online |

    • doi

    Cite article:- Kumar* Anil M., Reddy Krishna M., Sarangapani M. (2025). EFFECT OF NEW HETEROCYCLIC COMPOUND ON CARBOHYDRATE METABOLISM IN DIFFERENT TISSUES OF MALE ALBINO RATS. Indian Journal of Animal Research. 44(2): 135 - 138. doi: .

    ABSTRACT

    The present study is designed to study the effect of a new heterocyclic compound on
    glycogen, pyruvate and lactic acid contents in tissues to understand the carbohydrate metabolism
    and its role in male rats. The treatment with ethyl -1 -(5 –chloro -2 –oxoindolin -3
    ylideneamino) -1,2,3,6 –tetrahydro - 4 -methyl -2 -oxo -6 –phenyl pyrimidine -5 -carboxylate
    compound at dose level of 3 mg/kg/b.wt. for 21 days did cause a mild change in carbohydrate
    metabolism in reproductive and somatic tissues of treated rats. In order to assess physiological
    changes in testis, brain, heart, kidney and liver of rats, estimation of glycogen, pyruvate and
    lactic acid has been under taken. The result showed a mild decrease in glycogen and lactate
    levels but in contrast, same treatment caused a mild increase in pyruvate levels

    REFERENCES

    1. Ajitha, M. (2009). Ph.D.Thesis, Kakatiya University, Warangal, India.
    2. Anil Kumar, M. (2009). Asian J. BioSci. 4(2): 235-240.
    3. Annison, E.F. et al. (1963). Biochemical J. 88: 482.
    4. Barker, S.H. and Summerson, W.H. (1941). J. Biol. Chem. 138: 535-554.
    5. Bell, G.H. et al. (1972). Text Book of Physiology and Biochemistry, 18th Edn., Elbs and Churchill Livingston,
    6. U.K.
    7. Berry, L.J. and Smythe, D.S. (1959). Am. J. Physiol. 197: 37-40.
    8. Eshete, F. and Bennett, J.L. (1990). Expt. Parasitol. 91(1): 69-80.
    9. Friedman, T.E. and Haugen, G.E. (1943). J. Biol. Chem. 144: 67-77.
    10. Harper, H.A. et al. (1977). In Review of Physiological Chemistry,
    11. 16th Edn., Langer, Med. Publications, California.
    12. Huckbee, W.E. (1961). In Hawkis Physiological Chemistry, 14th Edn, (Ed. Oser, B.L.), New Delhi, Tata MC
    13. Graw-Hill. 1108.
    14. Jagadeesan, G. and Mathivanan, A. (1999). Poll. Res. 18(2): 177-181.
    15. Klicpera, M. et al. (1957). Physiol. Bohemoslov. 6: 569.
    16. Lang, S. and Lin, Y. (1984). In: Comprehensive Heterocyclic Chemistry, (Eds. Katrizky, A.R. and Rees,
    17. C.W.) Peragamon Press, Oxford. 6, 1-130.
    18. Neff, C.M. et al. (1987). Arctics. 40 (1): 220-229.
    19. Rastogi, R. et al. (1997). Drug Dev. Res. 41: 44.
    20. Samba Siva Rao, K.R.S. (1999). Pesticide impact on fish metabolism Discovery Publishing House, New
    21. Delhi, India, 66-70.
    22. Umminger, B.L. (1977). Comp. Biochem, Physiol. 55: 410- 416
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