Antiarthritic and antioxidant activities of gossypium herbaceum plant (cotton plant) leaves 

DOI: 10.18805/ag.D-4551    | Article Id: D-4551 | Page : 88-94
Citation :- Antiarthritic and antioxidant activities of gossypium herbaceum plant (cotton plant) leaves.Agricultural Science Digest.2018.(38):88-94
Narahari Srinivas Reddy and Akondi Butchi Raju drraju2020@gmail.com
Address : Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia
Submitted Date : 20-01-2017
Accepted Date : 19-04-2018

Abstract

Gossypium herbaceum commonly known as cotton plant cultivated world over and the main produce is used by the textile industries.   Other parts of this plant including leaves can also be explored for their best utilization, hence in this direction we have evaluated efficacy of cotton plant leaf extract against an inflammatory condition i.e rheumatoid arthritis.  Freund’s complete adjuvant (FCA) induced arthritis model was selected for this study and. All the rats received treatments of plant extract from 10th day of the induction of arthritis and continued up to 28 days of the study. Once in every 7 days, the arthritic assessments i.e. paw volume; body weight and paw erythema were assessed. Arthritic rats showed severe paw swelling, erythema, reduced body weight, abnormal changes in haematological, biochemical and antioxidant parameters (p<0.05) compared with normal control. Studies showed that treatment with MEGH (200mg/kg) was effective in reversing the symptoms and restore the normalcy by restoring the elevated parameters.  Over all the plant proved useful in treating Rheumatoid Arthritis in rodents and further studies in this direction are necessary to understand its mechanism. 

Keywords

Rheumatoid arthritis Freund’s complete adjuvant Gossypium herbaceum Methotrexate.

References

  1. Aghdassi E and Allard JP. (2000). Breath alkanes as a marker of oxidative stress in different clinical conditions. Free Radi Biol Med 28:880–886.
  2. Andersen HC, McCarthy M. (1950). Determination of C-reactive protein in the blood as a measure of the activity of the disease process in acute rheumatic fever. Am J Med 8: 445-455.
  3. Cai X, Wong YF, Zhou H, Xie Y, Liu ZQ and Jiang Z. (2006). The comparative study of Sprague–Dawley and Lewis rats in adjuvant induced arthritis. Naunyn-Schmiedebergs Arch Pharmacol 373:140-147.
  4. David B, Jyothi P, Otilia JF and Ranjith KA. (2011). Evaluation of the concominant use of methotrexate and curcumin on Freund’s complete adjuvant- induced arthritic and haematological indices in rats. Indian J Pharmacol 43:546-550. 
  5. Gomes A, Bhattacharya S, Chakraborty M, Bhattacharjee P, and Mishra R. (2010). Anti-arthritic activity of Indian monocellate cobra (Naja kaouthia) venom on adjuvant induced arthritis. Toxicon 55:670–673.
  6. Helen A, Sindhu G, Ratheesh M, Shyni GL and Bala Nambisan. (2012). Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. Int Immunopharmacol 12: 205–211.
  7. Kalyana ND, Ravindra Reddy K and Jayaveera KN. (2008). Study on the diuretic activity of gossypium herbaceum linn leaves extract in albino rats. Pharmacologyonline 1:78-81.
  8. Kokate CK, Purohit AP and Gokhale SB. (2007). Pharmacognosy. New Delhi: Nirali Prakashan Publication. pp. 297.
  9. Lau D, Mollnau H, Eiserich JP, Freeman, Daiber BA, Gehling A. (2005). Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci 102:431–436.
  10. Lixing Lao, Rui-Xin Zhang, Arthur Yin Fan.(2009). Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats. J Ethnopharmacol 121: 366-371.
  11. Nadkarni AK and Nadkarni KM. (2011). Indian Materica medica. 1: 587.
  12. Rainsford KD. (1982). Adjuvant polyarthritis in rats. Is this a satisfactory model for screening anti-arthritic drugs? Agents Actions 12:452-458.
  13. Rang HP, Dale MM, Ritter JM and Moore PK. (2011) Pharmacology. 7th ed. Edinburgh: Churchill Livingstone 15: 202-225.
  14. Saifuddin Khalid MD, Kamal Hasan S and Suresh DK. (2011). Antiulcer activity of Ethanolic extract of Gossypium Harbaceum flowers. RGUHS J Pharm Sci 1:79-84.
  15. Sharad MM, Arulmozhi S, Chinmay U. Kapase. (2011). anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund’s complete adjuvant induced arthritis. Biomag 1: 185–190.
  16. Sharma PK, Sisodia SS, Naruka PS and Porwal M. (2011). Invitro Antioxidant Activity of Gossypium herbaceum linn. Int Res J Pharm 2: 166 - 170.
  17. Singer JL and Plotz CM. (1956). The latex fixation test .I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med 21: 888-892. 
  18. Suk JS, Kap SK, Seung DL, Chang HL, Hoon SC and Un HJ. (2006). Effects and mechanisms of Clematis mandshurica Maxim. as a dual inhibitor of proinflammatory cytokines on adjuvant arthritis in rats. Environ Toxicol Pharmacol 22: 205-212.
  19. Van Eden W, Holoshitz J and Nevo Z.(1985). Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci 82:5117-5120. 

Global Footprints