Indian Journal of Animal Research

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Review Article

Camel Milk Yield and Composition and its Adjuvant Potential Impacts on Health of Consumers: A Review

A.A. Mohammed1,*, N. Alshaibani1
1Department of Animal and Fish Production, College of Agriculture and Food Sciences, King Faisal University, P.O. Box 402, Al-Ahsa 31982, KSA.

ABSTRACT

Dromedaries can be integrated efficiently into an extensive and intensive management milk production systems for producing milk. Camel milk has specific nutritional values that alleviate certain diseases. The camel milk can be produced under harsh and intensive management conditions. Camel milk was given to human and experimental animal species under normal and dysfunction conditions as hyperglycemic, hyperlipidemic and hepatitis. The articles concerning management conditions of producing camel milk and its specific nutritive values were used for writing the manuscript and they were collected from google scholar, ScienceDirect, PubMed databases. The results indicated that camels species were significantly produced milk either under harsh or intensive management conditions. The constituents of chemical camel milk were differed among species, stage of lactation, and management systems. The nutritional values of camel milk were explored as antihyperglycemic, antihyperlipidemic, anti-cancer, and others. The possible biological candidates in camel milk include lactoglobulins, lactoferrin, and lysozyme. It could be concluded that camel milk has a potential nutritional therapy, where it is effected on blood glucose values, liver and kidney functions.

INTRODUCTION

The world population is projected to reach 9.7 billion by the year 2050 and 10.4 billion by the year 2100 due to higher life expectancy and decreasing mortality. Water and food security are among the priorities of the 21st century that cannot be achieved without intensive and sustainable agriculture production. Therefore, providing food for humans is an urgent need through intensification and expansion of livestock and crop production, which started some decades ago (Gilbert et al., 2021). Camels are the most important animal species adapted to survive in the harsh environmental conditions in addition to their abilities to produce milk, meat and offspring (Kakar et al., 2008; Mohammed and Mahmoud, 2011; Djenane and Aider, 2024; Mohammed and Alshaibani, 2024).  
       
The number of camels is approximately estimated to be more than 35 million heads at world level (FAO 2013; Tharwat et al., 2023). The roles of camels in the livestock economy of countries is highly variable according to different factors including species, management systems and environmental factors (Faye, 2020; Chamekh et al., 2020) (Table 1). There is a continuous increase in the total number of dairy camels and this is resulted in a noticeable increase in camel milk production (El-Hanafy et al., 2023).
 

Table 1: Camel milk production and composition factors.


       
It has been estimated that about 2.12 million tons of camel milk was produced from 5.25 million of she-camels in 2010 (Ramadan and Inoue-Murayama, 2017). Camel milk represents an important protein source for people living in the arid regions of the world as nomadic communities (Arain et al., 2024). Several studies in the last two decades were explored the changes in camel milk production and composition in addition to their potential effects for body health and therapeutic of certain diseases in experimental animals and humans (Faye, 2020; Chamekh et al., 2020; Liu et al., 2023; Djenane and Aider, 2024). Therefore, the aims of this review article were designed to provide a comprehensive overview concerning the changes in milk production and composition due to management system, the nutritional value of camel milk and its potential impacts on body health and therapeutic of certain diseases (Fig 1). 
 

Fig 1: Camel milk production and its effect on body functions and therapeutic of diseases.


       
The experimental procedure was approved by the ethical committee of King Faisal University [Ref. No. KFU-REC-2024-AUG-EA050]. The articles concerning anatomy of the dromedary mammary gland, factors affecting camel milk yield and composition, camel milk composition and nutritional value, camel milk as a potential therapeutic for hyperglycemia, hyperlipidemia and others were collected form SciencDirect, PubMed and Google Scholar databases. Therefore, our targets are to highlight key aspects of camel milk production and composition and it is effect on body health and therapeutic of diseases.
 
Functional anatomy of the dromedary mammary gland
 
The udder of the dromedaries is divided longitudinally through the Sulcus intermammarius into right and left halves. Each half is divided into front and back quarters (Fig 2). The shape of udders and teats differs between camels, where is influenced by species, age and lactational stage. The udder form was mostly globular udder and the teat form was the funnel one (Müller et al., 2024). Each quarter of the camel udder consists of two distinct glands (Fowler, 1998). The gland consists of teat cistern and extensive branching ducts, which were divided into large, medium, and small milk ducts. The hindquarters produce about (56.4%) of udder milk compared to (43.6%) of the front quarters. Ohari and Joshi (1961) showed that the milk composition is similar between fore and hindquarters. The knowledge of anatomical dromedary udder structures may be useful for selection of dairy dromedaries and application of automatic or machine milking. Atigui et al., (2021) explored the correlation between udder characteristics and milk flow rates of dairy camels. They stated that daily milk yield and milk flow rate were highly correlated with udder depth and teat diameter. Therefore, recognition of factors that effect on camel machine milking ability for camels has decisive implications for adjusting the machine design and management.
 

Fig 2: Morphology of udder she-camel.


 
Factors affecting camel milk yield and composition
 
Camel milk yield and composition monitoring throughout lactation is a target for exploiting camel potential and understanding factors of variation. Dairy camels were categorized into three groups, low, medium and high according to their milk yield and lactational length ranges from 6 to 18 months (Alhadrami and Faye, 2016). Hand milking and longer calving interval retard progress in improving camel milk yield and quality. Camel milk yield from intensive management system has shown promising result (Chamekh et al., 2020). Although the peak of lactation tends to decline more steeply in camels compared to dairy cattle, camel provide milk to people living in the arid and semi-arid area better than sheep, goats and cows (Alhadrami, 2002). The effects of genetic and non-genetic factors on milk yield and compositions have been explored in several studies (Table1).
 

Table 1: Camel milk production and composition factors.


 
Camel milk nutritional values
 
Composition of camel milk is similar to composition of goat and cattle milk (Yasmin et al., 2020). Camel milk has opaque white colour and sweet taste but it can be salty sometimes due to feeding strategies (Alhadrami 2002). Camel milk has high nutritional value and health benefit (Nikkah 2011; Ganzorig et al., 2020). Camel milk includes nutrients including proteins, fats, lactose, vitamins, minerals, etc (El-Hanafy et al., 2023). Our unpublished data of camel milk composition of Majahem breed under intensive management system during the first month of lactation indicated 3.35% proteins, 4.11% fats, 4.88% lactose, 9.08% solid none fat, 1.0262 density, 0.58% minerals (Mohammed and Alshibani unpublished).
       
As mentioned earlier, camel milk production and composition is influenced by different factors including breeds, age, parity, management systems and environmental conditions. After consuming, digestion and absorption of camel milk produces in the small intestine peptides, which aid in treatments of diabetes and hypertension, and delay liver and kidney damages. Moreover, the various camel milk biological activities may be related to its exosomes (Liu et al., 2023). Camel milk contains lactoglobulins, lactoferrin, and lysozymes higher than cattle milk. In addition, camel milk has been indicated to have hypoallergenicity properties compared to cattle milk. Besides, camel milk has similar nutritional composition and curative properties compared to human milk (Oselu et al., 2022).
 
Camel milk as a potent superfood for potential therapeutic of diseases
 
Camel milk, because of its unique properties, has been used to treat some diseases in certain regions of Africa and Asia since ancient times and researchers have recently begun to explore these disease-curing claims using camel milk and camel milk products (Kanha, 2010). Evidences from laboratory and medical studies indicate that camel milk and/or urine are effectives in treating many diseases such as diabetes, cancer, viral hepatitis, autism, food allergies and a group of other bacterial, viral and parasitic infections (Alavi et al., 2017; Oselu et al., 2022; Shakeel et al., 2022).
 
Antihyperglycemic effects of camel milk
 
Diabetes is a worldwide metabolic disease and is currently a topic of great interests, which necessitated effective alternative treatments (Pandey et al., 2011; Mirmiran et al., 2017). Diabetes is a disease recognized by high blood sugar that results from failure of pancreas to secrete the adequate amount of insulin hormone (Type I) or inability of target cells including muscle, liver and fat cells to respond to hormone insulin action (Type II) (Tuomilehto 2013; Zheng et al., 2018).
       
Camel milk is suggested to be a suitable hypoglycemic factor in patients with diabetes and experimental animals (AlKurd et al., 2022; Mohammadabadi and Jain, 2024). Clinical studies for patients with type I diabetes have shown that consuming camel milk lowers blood glucose value and reduces the amount of insulin required for treatment by 30-35% (Mirmiran et al., 2017; Mohammadabadi and Jain, 2024). Agrawal et al., (2007) found zero prevalence of diabetes in north-west Rajasthan community consuming camel milk. It appears that camel milk contains insulin-like proteins that enhance health of diabetic patients. The mechanism of action is suggested in the following scheme (Fig 3).
 

Fig 3: Antihyperglycemic effects of insulin-like proteins of camel milk.


       
Mucosal surfaces are the pathway for proteins and peptides (Garcia-Castillo et al., 2018). However, when insulin is given orally, it encounters mucosal barriers and is digested by digestive enzyme before entering blood stream. As a unique property of camel milk, insulin-like proteins are protected in the stomach and are efficiently absorbed into the bloodstream until they reach the target location in the body’s cells. This is because camel milk does not curdle in an acidic condition (Agrawal et al., 2004). Since there was no differences in the composition of the camel insulin-like proteins and their digestibility’s compared to proteins of other dairy sources, it is possible that the camel insulin-like proteins are protected in the stomach by nanoparticle as lipid vesicles to reach the target cells (Malik et al., 2012). Camel milk contains about 52 mU/ml of insulin-like proteins compared to 16.32 mU/ml for cattle milk, which mimics the interaction of insulin with its receptors. It has a high content of zinc (Konuspayeva et al., 2022) and has a key role in the secretory activity of insulin from pancreatic β-cells (Anwar et al., 2022). Beg et al., (1986) found that the amino acid sequences in camel milk proteins are rich in a half cystine compound, which has a surface similar to peptides of the insulin family.
       
Some investigators propose that camel insulin-like proteins have the ability to resist proteolytic digestion, which makes its absorption into the blood faster than those from other dairy milk sources. It has been shown that raw camel milk has the ability to reduce blood sugar levels by about 55.0% compared to cow’s milk in diabetic rats (Kamal et al., 2007). Fresh or raw camel milk showed a higher ability to lower blood glucose levels than pasteurized camel milk during a four-week period of treatment (Agrawal et al., 2005a, b). Similar results were obtained in dogs and rabbits (El-Said et al., 2010). In addition, the insulin level in serum was higher in diabetic rabbits treated with camel milk compared to those not treated with camel milk or insulin treatment during a period of four weeks. In rabbits with diabetes, treatment with camel milk has a much higher ability to lower blood glucose levels than biosynthetic insulin.
       
Agrwal et al., (2003) found that camel milk reduced blood glucose levels when given as an adjuvant treatment for type I diabetics for three months. At the end of the three months, it was found that there was a significant decrease in the doses of insulin required to control blood sugar, in addition to a significant increase in the level of hemoglobin type. Therefore, giving type I diabetics a treatment that includes camel milk in addition to insulin is better than giving either one alone. Finally, researchers believe that camel milk can be safely consumed by individuals without diabetes or healthy people (Cheikh Ismail et al., 2022; Profeta et al., 2022).
 
Antihyperlipidemic effect of camel milk
 
Diabetes is accompanied with changes in blood lipids, triglycerides and lipoprotein (Hirano 2018; Yang et al., 2022). It results in vascular and heart complications (Li et al., 2023; Zakir et al., 2023). Thus, lowering cholesterol values using diet or medical treatment appears to reduce risk of heart disease (Hooper et al., 2020). Low-density lipoprotein-C in the blood passes to the liver through specific receptors (Pirahanchi et al., 2023; Feingold, 2024). An increase in the blood plasma levels of LDL in diabetics leads to a defect in the LDL-C receptors, resulting in a defect in their production or function (Li et al., 2023). LDL-C is a protective substance for the body by reversing cholesterol transport, preventing the oxidation of LDL-C and neutralizing the atherogenic effects of oxidized LDL-C (Ahotupa, 2024). There is an association between the level of very low-density lipoprotein-C and HDL-C. A significant increase in both LDL-C and VLDL-C may lead to a significant decrease in HDL-C levels. In addition, low levels of HDL-C may also occur due to decreased activity of the enzyme lecithin cholesterol acyltransferase (Al-Numair, 2010).
       
Several studies have shown that camel milk can help lower lipid profiles in diabetic patients (Khalid et al., 2023). Camel milk reduced total cholesterol values in dogs induced with diabetes using Alloxan drug compared to cow’s milk (Sboui et al., 2010). Moreover, camel milk also improved fat properties even after five weeks of stopping to drink camel milk (Sboui et al., 2010). AL-Numair (2010) stated that camel milk is able to reduce blood lipids. In this study, diabetic rats treated with camel milk for 45 days had a significant reduction in the levels of total cholesterol, triglycerides, free fatty acids (FFA’s), phospholipids, low-density lipoproteins and lipoproteins. Very low-density lipoprotein in plasma and tissues (kidney, liver, heart) increased while high-density lipoprotein decreased. Similar results were obtained in other study of diabetic rabbits treated with camel milk (El-Said et al., 2010).
       
Mohamad et al., (2009) demonstrated the effectiveness of camel milk as a superfood treatment for patients with type I diabetes, as total cholesterol and triglycerides decreased to 25% and 37%, respectively, after consuming camel milk for 16 weeks, while no significant change occurred in HDL, LDL and VLDL values. Patients with type I diabetes treated with insulin, camel milk, or both were showed the efficiency of both insulin and camel milk in improving lipid profiles compared to insulin or camel milk alone (El-Sayed et al., 2011). Collectively, it could be concluded that the health-promoting effect of camel milk supports its role in treating dyslipidaemia.
 
Liver and kidney functions through camel milk
 
Prevalence of liver disease and increased levels of liver enzymes are common in individuals with diabetes. Evaluating the levels of liver enzymes in the blood (AST and ALT) reflects the release of liver enzymes from its cells into the blood as a sign of injury (Lala et al., 2023; Mohammed et al., 2024a, b, c). The beneficial effects of camel milk on human health extend to liver and kidney functions. A significant improvement was found in the liver enzymes of diabetic rats that were treated with camel milk (Khan et al., 2012; Alharbi et al., 2022).
       
Microvascular kidney dysfunction in diabetic patients is widely considered one of the risks of diabetes (Jha et al., 2024). It has been known that albuminuria is a sign of kidney dysfunction (Pasternak et al., 2022). The urine albumin level within 24 hours ranges from 30-300 mg per urine sample (Prasad et al., 2023). It has been found that camel milk has a potential role in the urine albumin level of patients with type I diabetes (Agrwal et al., 2009). A significant decrease in urine albumin was found for patients with type I diabetes when camel milk was added to their diet for six months. Moreover, kidney function through uric acid, urea and creatine levels were returned to normal values in diabetic rats given camel milk (Hamad et al., 2011; Badr 2013). Collectively, liver and kidney functions were improved upon consuming camel milk either in normal or diabetic conditions.

CONCLUSION

Camel milk can be significantly produced either under harsh or intensive management conditions. The chemical constituents of camel milk were differed among species, stage of lactation and management systems. The  consumption of camel milk due to its nutritional values as superfood provides benefits to healthy people and patients with antihyperglycemic, antihyperlipidemic, anti-cancer, liver and kidney malfunctions and others. Further studies are required for improvement camel milk production and quality and the constituents involved in therapy of diseases.

ACKNOWLEDGEMENT

The authors want to thank and acknowledge Deanship of Scientific Research, King Faisal University, Saudi Arabia for funding and support (KFU 241668).
 
Disclaimers
 
The views and conclusions expressed in this article are solely those of the authors and do not necessarily represent the views of their affiliated institutions. The authors are responsible for the accuracy and completeness of the information provided, but do not accept any liability for any direct or indirect losses resulting from the use of this content.
 
Informed consent
 
Not applicable

CONFLICT OF INTEREST

The authors declare that there are no conflicts of interest regarding the publication of this article. No funding or sponsorship influenced the design of the study, data collection, analysis, decision to publish, or preparation of the manuscript.

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