Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 54 issue 5 (may 2020) : 627-630

Perioperative analgesic efficacy of constant rate infused tramadol hydrochloride as an adjunct to postoperative ketoprofen in ovariohysterectomized bitches

N.E. Ugwu, C.A. Eze, R.I. Udegbunam, T.O. Nnaji
1Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Cite article:- Ugwu N.E., Eze C.A., Udegbunam R.I., Nnaji T.O. (2018). Perioperative analgesic efficacy of constant rate infused tramadol hydrochloride as an adjunct to postoperative ketoprofen in ovariohysterectomized bitches. Indian Journal of Animal Research. 54(5): 627-630. doi: 10.18805/ijar.B-984.
The study evaluated the peri-operative analgesic efficacy of tramadol administered by constant rate infusion as an adjunct to ketoprofen in ovariohysterectomized bitches.  Pre- and postoperative assessment of pain was made using physiologic parameters, glucose, cortisol, pain score and body weight. Dogs were randomly assigned to one of the three groups using the protocol: 1.0mg/kg/hr, 2.0mg/kg/hr of CRI tramadol and control. Ketoprofen (5mg/kg, SC) was administered at one, twenty-four and seventy-two hours post-OVH to all the dogs. Mean glucose and cortisol levels of group 3 dogs were at intra- and at one-hour post-OVH higher (p<0.05) than those of groups 1 and 2. Mean pain score of group 3 was significantly higher (p<0.05) than those of groups 1 and 2 at one, four, twenty-four and seventy-two hours post-OVH. The use of CRI tramadol at doses of 1.0mg/kg/hr and 2.0mg/kg/hr attenuated rise in pain markers and produced balanced analgesia as an adjunct to ketoprofen. 
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