Association of single nucleotide polymorphisms in the insulin and growth hormone gene with growth traits of Mia Chicken

DOI: 10.18805/ijar.B-955    | Article Id: B-955 | Page : 661-666
Citation :- Association of single nucleotide polymorphisms in the insulin and growth hormone gene with growth traits of Mia Chicken.Indian Journal Of Animal Research.2020.(54):661-666
Nguyen Hoang Thinh, Hoang Anh Tuan, Nguyen Thi Vinh, Bui Huu Doan, Nguyen Thi Phuong Giang, Farnir Frédéric, Moula Nassim, Nguyen Viet Linh and Pham Kim Dang nhthinh@vnua.edu.vn
Address : Faculty of Animal Science, Vietnam National University of Agriculture; Hanoi, Vietnam.
Submitted Date : 23-03-2018
Accepted Date : 13-03-2019

Abstract

This study was conducted in Mia chicken breed to evaluate the association between four single nucleotide polymorphisms (SNPs), in insulin (INS) and growth hormone (GH) genes, with growth traits. Three genotypes for the SNP A3971G of INS gene and the SNP G662A and C423T of GH gene were present in the population while only two genotypes were found in the Mia chicken breed for SNP T3737C of INS gene (TT and TC). The SNP T3737C INS gene and G662A GH gene had significant association with growth traits (P < 0.05). A significant association of T3737C INS gene with body weight (BW) was observed at 10 to 12 weeks of age and average daily gain (ADG) at 6-8 weeks of age. The SNP G662A of the GH gene was significantly associated (P < 0.05) with BW of Mia chicken at ages from 7 to 14 weeks and with ADG (4-6; 6-8; 8-10; 10-12 and 2-16 weeks). Chicken with the GG genotype had greater BW and ADG compared to the other genotypes. The results demonstrated that this SNP G662A GH gene may be used as a candidate marker gene for genetic improvement of growth traits in Mia chicken breed.

Keywords

GH gene INS Mia chickens SNPs.

References

  1. Amills, M., Jimenez, N., Villalba, D., Tor, M., Molina, E., Cubilo, D., Marcos, C., Francesch, A., Sanchez, A., Estany, J. (2003). Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits. Poultry Science. 83: 1458-1493. 
  2. Albariño, C.G. and Romanowski, V. (1994). Phenol extraction revisited: a rapid method for the isolation and preservation of human genomic DNA from whole blood. Molecular and Cellular Probes. 8: 423 - 427. 
  3. Dekker, J.C.M. (2004). Commercial application of marker- and gene-assisted selection in livestock: Strategies and lesson. Journal of Animal Science. 82(E. Suppl.): E313–E328. 
  4. Berthouly-Salazar, C., Rognon, X., Van, T.N., Gély, M., Chi, C.V., Tixier-Boichard, M., et al., (2010). Vietnamese chickens: a gate towards Asian genetic diversity. BMC Genetics. 11:53. 
  5. Desvaux, S., Ton, V.D., Thang, P.D., Hoa, P.T.T. (2008). A general review and a description of the poultry production in Vietnam. Agricultural Publisher, Hanoi, Vietnam. http://hdl.handle.net/2268/157619
  6. FAO. (2008) Poultry production systems in Vietnam. GCP/RAS/228/GER Working Paper No. 4. Rome.
  7. Feng, X. P., Kuhnlein, U., Aggrey, S.E., Gavora, J.S., Zadworny, D. (1997). Trait association of genetic markers in the growth hormone and the growth hormone receptor gene in a White Leghorn Strain. Poultry Science. 76:1770-1775.
  8. Hadley, M. E. (2000). Endocrinology, 5th ed. Prentice Hall, London, UK pp 256 - 257.
  9. Hong Hanh, P.T., Burgos, S., Roland-Holst, D. (2007). The poultry sector in Vietnam: prospects for smallholder producers in the aftermath of the HPAI crisis. Food and Agriculture Organization of the United Nations, Pro-Poor Livestock Policy Initiative (PPLPI) Research Report, August 2007.
  10. Jiang, R., Li, J., Qu, L., Li, H., Yang, N. (2004). A new single nucleotide polymorphism in the chicken pituitaryspecific transcription factor (POU1F1) gene associated with growth rate. Animal Genetics. 35:344–346. 
  11. Khoa, D.V.A., Khang, N.T.K., Ngu, N.T., Matey, J., Loan, H.T.P., Thuy, N.T.D. (2013). Single nucleotide polymorphisms in gh, ghr, ghsr and insulin candidate genes in chicken breeds of Vietnam. Greener Journal of Agricultural Sciences. 3 (10): 716-724.
  12. Lei, M., Luo, C., Peng, X., Fang, M., Nie, Q., Zhang, D., Yang, G., Zhang, X. (2007). Polymorphism of growth-correlated genes associated with fatness and muscle fiber traits in chickens. Poultry Science. 86:835–842. 
  13. Ly, L. V., Tien, B.Q., Tieu, H.V., Lung, B.D., Minh, N.T., Thuy, L.T. (2001). Conservation of Livestock Gene pool in Vietnam, Poultry Section. Hanoi Agricultural Publishing.
  14. Mehdi, A. and Reza, F. A. (2012). Single nucleotide polymorphisms in intron 1 of growth hormone gene and it’s association with economic important traits in Iranian Fars native fowl. Annals Biological Research. 3 (8): 4028-4032.
  15. Minh, D.V., Lindberge, J.E., Ogle, B. (2006). Effect of season and location on the crop and contents of local and improved scavenging hens in Northern Vietnam. Tropical Animal Health and Production. 38: 121–129.
  16. Moula, N., Luc, D.D., Dang, P.K., Farnir, F., Ton, V.D., Binh, D.V., Leroy, P., Moussiaux, N.A. (2011). The Ri chicken breed and livelihoods in North Vietnam: characterization and prospects. Journal Of Agriculture And Rural Development In The Tropics And Subtropics. 112 (1): 57-69. 
  17. Nadaf, J., Gilbert, H., Pitel, F., Berri, C.M., Feve, K., Beaumont, C., Duclos, M.J., Vignal, A., et al., (2007). Identification of QTL controlling meat quality traits in an F2 cross between two chicken lines selected for either low or high growth rate. BMC Genomics. 8:155. 
  18. Nie, Q., Sun, B., Zhang, D., Luo, C., Ishag, N.A., Lei, M., Yang, G., Zhang, X. (2005). High diversity of the chicken growth hormone gene and effects on growth and carcass traits. Journal of Heredity. 96(6): 698-703. 
  19. Pham, M.H., Berthouly-Salazar, C., Tran, X.H., Chang, W.H., Crooijmans, R.P.M.A., et al.,(2013). Genetic diversity of Vietnamese domestic chicken populations as decision-making support for conservation strategies. Animal Genetics. 44 (5): 509–521.
  20. Promwatee, N., Laopaiboon, B., Vongpralub, T., Phasuk, Y., Kunhareang, S., Boonkum, W., Duangjinda, M. (2013). Insulin-like growth factor I gene polymorphism associated with growth and carcass traits in Thai synthetic chickens. Genetics and Molecular Research. 12:4332-4341. 
  21. Qiu, F.F., Nie, Q.H., Luo, C.L., Zhang, D.X., Lin, S.M., Zhang, X.Q. (2006). Association of single nucleotide polymorphisms of the insulin gene with chicken early growth and fat deposition. Poultry Science Journal. 85: 980-985. 
  22. Tanaka, M., Hosokawa, Y., Watahiki, M., Nakashima, K. (1992). Structure of the chicken growth hormone-encoding gene and its promoter region. Gene. 112: 235-239.
  23. Vasilatos-Younken, R., Zhou, Y., Wang, X., Mcmurtry, J.P., Rosebrough, R.W., Decuypere, E., et al., (2000). Altered chicken thyroid hormone metabolism with chronic GH enhancement in vivo: consequences for skeletal muscle growth. Journal of    Endocrinology. 166: 609-620. 
  24. Wilcox, G. (2005). Insulin and insulin resistance. The Clinical Biochemist Reviews. 26: 19-39.
  25. Zhang, X.L., Jiang, X., Liu, Y.P., Du, H.R., Zhu, Q. (2007). Identification of avaI polymorphisms in the third intron of GH Gene and Their associations with abdominal fat in chickens. Poultry Science. 86:1079–1083. 

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